189188-57-6

• 常用中文名：马来酸替加色罗
• 常用英文名：Tegaserod maleate
• CAS号：189188-57-6
• 分子式：C₂₀H₂₇N₅O₅
• 分子量：417.459
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 5-HT受体
• 发布时间：2018-08-30 11:11:22
• 更新时间：2026-07-09 11:59:56
• Tegaserod马来酸盐是5-HT4激动剂。

名称

• 中文名: 马来酸替加色罗
• 英文名: tegaserod maleate
• 中文别名: 2-[(5-甲氧基-1H-吲哚-3-基)亚甲基]-N-戊基卡巴肼马来酸盐; 2-((5-甲氧基-1H-吲哚-3-基)亚甲基)-N-戊基肼-1-甲脒 马来酸盐; 马来酸替加色罗杂质; 马来酸替加色罗,10 MM DMSO 溶液
• 英文别名: TEGASEROD MALEATE; ZELNORM;SDZ-HTF-919;HTF-919;ZELMAC; Tegaserod (maleate); ZELMAC; Tegaserod Maleate; Tegaserod maleate, 10 mM in DMSO; TegastrodMaleate; Zelnorm; Tegaserod maleate //BP; Hydrazinecarboximidamide, 2-[(5-methoxy-1H-indol-3-yl)methylene]-N-pentyl-, (2E)-, (2Z)-2-butenedioate (1:1); Tegaserod Maleate,; Tegaserod Hydrogen Maleate; MFCD04116201; acide (2Z)-but-2-ènedioïque - (2E)-2-[(5-méthoxy-1H-indol-3-yl)méthylidène]-N-pentylhydrazinecarboximidamide (1:1); SDZ-HTF-919, Zelmac, 2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentylhydrazinecboximidamide, Maleate; 2-[(5-methoxy-1h-indole-3-yl)methylene]-n-pentylcbazimidamide hydrogen maleate; (2Z)-But-2-endisäure--(2E)-2-[(5-methoxy-1H-indol-3-yl)methyliden]-N-pentylhydrazincarboximidamid(1:1); 2-[(5-Methoxy-1H-indol-3-yl)Methylene]-N-pentylhydrazinecboxiMidaMide (2Z)-2-Butenedioate; 2-((5-Methoxy-1H-indol-3-yl)methylene)-N-pentylhydrazine-1-cboximidamide maleate; (2E)-2-[(5-methoxy-1H-indol-3-yl)methylidene]-N-pentylhydrazinecarboximidamide (2Z)-but-2-enedioate; (2E)-2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentylhydrazinecarboximidamide (2Z)-2-butenedioate; (2E)-2-[(5-methoxy-1H-indol-3-yl)methylidene]-N-pentylhydrazinecarboximidamide (2Z)-but-2-enedioate (1:1); Tegaserod maleateQ: What is Tegaserod maleate Q: What is the CAS Number of Tegaserod maleate Q: What is the storage condition of Tegaserod maleate Q: What e the applications of Tegaserod maleate; Hydrazinecboximidamide, 2-[(5-methoxy-1H-indol-3-yl)methylene]-N-pentyl-, (2Z)-2-butenedioate (1:1); Tegibs 6; Tegaserol Maleate; TegaserodMalate; ZelnorM; 2-[(5-METHOXY-1H-INDOL-3-YL)METHYLENE]-N-PENTYLHYDRAZINECBOXIMIDAMIDE, MALEATE; Zelmac; SDZ-HTF-919; Toromifene; (2E)-2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentylhydrazinecarboximidamide (2Z)-but-2-enedioate (1:1); 1-[(5-methoxy-3-indolylidene)methylamino]-2-pentylguanidine; (2E)-2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentylhydrazinecarboximidamide (2Z)-2-butenedioate (1:1)

物化性质

• 沸点: 661.4ºC at 760 mmHg
• 熔点: 180-183ºC
• 分子式: C₂₀H₂₇N₅O₅
• 分子量: 417.459
• 闪点: 353.8ºC
• 精确质量: 417.201233
• PSA: 149.45000
• LogP: 3.10190
• 外观性状: 白色粉末
• 蒸汽压: 2.15E-18mmHg at 25°C
• 储存条件: -20°C Freezer

生物活性

• 描述: Tegaserod马来酸盐是5-HT4激动剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Bushman J, et al. Tegaserod mimics the neurostimulatory glycan polysialic acid and promotes nervous system repair. Neuropharmacology. 2014 Apr;79:456-66.

  [2]. Yan C, et al. Effect of the 5-HT4 receptor and serotonin transporter on visceral hypersensitivity in rats. Braz J Med Biol Res. 2012 Oct;45(10):948-54.

  [3]. Painsipp E, et al. Alosetron, cilansetron and tegaserod modify mesenteric but not colonic blood flow in rats. Br J Pharmacol. 2009 Nov;158(5):1210-26.

安全

• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2933990090

合成路线

110-16-7 145158-71-0 ~72% 189188-57-6

文献：Venkataraman, Sundaram; Gudipati, Srinivasulu; Mandava Venkata Naga, Brahmeshwararao; Banda, Goverdhan Reddy; Singamsetty, Radhakrishna Patent: US2005/272802 A1, 2005 ; Location in patent: Page/Page column 2-3 ;

上下游产品

上游产品  2
110-16-7 145158-71-0
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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%