95734-82-0

• 常用中文名：奈达铂
• 常用英文名：Nedaplatin
• CAS号：95734-82-0
• 分子式：C₂H₈N₂O₃Pt
• 分子量：303.181
• 相关类别： 生物化工 抑制剂 DNA损伤(DNA Damage) DNA/RNA Synthesis 抑制剂
• 发布时间：2018-05-30 08:00:00
• 更新时间：2024-01-03 19:17:05
• Nedaplatin是顺铂衍生物和DNA损伤剂。

名称

• 中文名: 奈达铂
• 英文名: nedaplatin
• 中文别名: 顺糖氨铂
• 英文别名: (glycolato-O,O')diammine platinum(II); 2,2-diaMino-1,3-dioxa-2-platinacyclopentan-4-one; Platinum, [2-(hydroxy-κO)acetato(2-)-κO]-, ammoniate (1:2); [(Hydroxy-κO)acetato(2-)-κO]platinum diammoniate; Nedaplatin; o(sup2))-diammine(hydroxyacetato(2-)-o(sup1(sp-4-3)-platinu; cis-diammine(glycolato)platinum(ii); PlatinuM,diaMMine[(hydroxy-kO)acetato(2-)-kO]-,(SP-4-3); Nedaplait; 254-s; cis-diamine-glycolate-O,O'-platinum(II)

物化性质

• 沸点: 265.6ºC at 760 mmHg
• 分子式: C₂H₈N₂O₃Pt
• 分子量: 303.181
• 闪点: 128.7ºC
• 精确质量: 303.018280
• PSA: 42.01000
• LogP: 0.12010
• 外观性状: 稻黄色粉末
• 储存条件: 2-8°C

生物活性

• 描述: Nedaplatin是顺铂衍生物和DNA损伤剂。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成
  研究领域 >> 癌症
• 参考文献:

  [1]. Kanzawa, F., et al., In vitro synergistic interactions between the cisplatin analogue nedaplatin and the DNA topoisomerase I inhibitor irinotecan and the mechanism of this interaction. Clin Cancer Res, 2001. 7(1): p. 202-9.

  [2]. Uchida, N., et al., Sequence-dependent antitumour efficacy of combination chemotherapy of nedaplatin, a novel platinum complex, with 5-fluorouracil in an in vivo murine tumour model. Eur J Cancer, 1998. 34(11): p. 1796-801.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TP2482800 CHEMICAL NAME : Platinum, diammine(hydroxyacetato(2-)-O(sup 1),O(sup 2))-, (SP-4-3)- CAS REGISTRY NUMBER : 95734-82-0 LAST UPDATED : 199612 DATA ITEMS CITED : 14 MOLECULAR FORMULA : C2-H8-N2-O3-Pt MOLECULAR WEIGHT : 303.21 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - changes in sodium TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 44100 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 4 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 48600 ug/kg/26W-I TOXIC EFFECTS : Cardiac - other changes Kidney, Ureter, Bladder - other changes Endocrine - other changes TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 10800 ug/kg/26W-I TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in platelet count Related to Chronic Data - changes in testicular weight TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 45 mg/kg/30D-I TOXIC EFFECTS : Sense Organs and Special Senses (Ear) - change in acuity Sense Organs and Special Senses (Ear) - changes in cochlear structure or function TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 13 mg/kg SEX/DURATION : female 17-21 day(s) after conception lactating female 20 day(s) post-birth TOXIC EFFECTS : Reproductive - Maternal Effects - other effects Reproductive - Effects on Newborn - physical Related to Chronic Data - changes in ovarian weight TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 4500 ug/kg SEX/DURATION : female 17-21 day(s) after conception lactating female 20 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - physical TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 46 mg/kg SEX/DURATION : male 64 day(s) pre-mating female 2 week(s) pre-mating - 7 day(s) after conception TOXIC EFFECTS : Reproductive - Paternal Effects - other effects on male Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 46 mg/kg SEX/DURATION : male 64 day(s) pre-mating female 2 week(s) pre-mating - 7 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 750 mg/kg SEX/DURATION : female 7 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system MUTATION DATA TEST SYSTEM : Rodent - mouse DOSE/DURATION : 6300 ug/kg REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 22,821,1991

安全

• 危害码 (欧洲): Xn

合成路线

41575-87-5 25289-18-3 ~28% 95734-82-0

文献：Totani, Tetsushi; Aono, Katsutoshi; Komura, Michihiro; Adachi, Yasuko Chemistry Letters, 1986 , p. 429 - 432

79-14-1 41575-87-5 ~43% 95734-82-0

文献：Totani, Tetsushi; Aono, Katsutoshi; Komura, Michihiro; Adachi, Yasuko Chemistry Letters, 1986 , p. 429 - 432

79-14-1 63700-88-9 25289-18-3 ~% 95734-82-0

文献：Chemistry Letters, , p. 429 - 432

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