82-89-3

• 常用中文名：灵菌红素
• 常用英文名：Prodigiosine
• CAS号：82-89-3
• 分子式：C₂₀H₂₅N₃O
• 分子量：323.43
• 相关类别： 原料药 抗寄生虫病药 抗阿米巴病及抗滴虫病药
• 发布时间：2018-06-13 19:40:16
• 更新时间：2024-01-03 17:52:23
• Prodigiosin (Prodigiosine) 是共生菌的次级代谢物,具有抗真菌和抗肿瘤活性。

名称

• 中文名: 灵菌红素
• 英文名: prodigiosin
• 英文别名: 4-Methoxy-5-(4-pentyl-5-methyl-2H-pyrrole-2-ylidenemethyl)-2,2'-bi[1H-pyrrole]; 4-Methoxy-5-[(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl],2,2'bipyrrole; 4-Methoxy-5-[(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl]-2,2'-bi[1H-pyrrole]; Prodigiosine; PRODIGIOSIN; 4-Methoxy-5-[(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl]-2,2'-bi[1H-pyrrol]; 2,2'-Bi-1H-pyrrole,4-Methoxy-5-[(5-Methyl-4-pentyl-2H-pyrrol-2-ylidene)Methyl]

物化性质

• 密度: 1.12g/cm3
• 沸点: 542.4ºC at 760 mmHg
• 分子式: C₂₀H₂₅N₃O
• 分子量: 323.43
• 闪点: 281.8ºC
• 精确质量: 323.20000
• PSA: 53.17000
• LogP: 4.77610
• 折射率: 1.591
• 储存条件: 避光,-20°C储存,干燥

生物活性

• 描述: Prodigiosin (Prodigiosine) 是共生菌的次级代谢物,具有抗真菌和抗肿瘤活性。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 真菌
• 靶点:

  Fungal[1]

• 参考文献:

  [1]. Woodhams DC, et al. Prodigiosin, Violacein, and Volatile Organic Compounds Produced by Widespread Cutaneous Bacteria of Amphibians Can Inhibit Two Batrachochytrium Fungal Pathogens. Microb Ecol. 2018 May;75(4):1049-1062.

  [2]. Wang Z, et al. Prodigiosin inhibits Wnt/β-catenin signaling and exerts anticancer activity in breast cancer cells. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13150-13155.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DW2977000 CHEMICAL NAME : 2,2'-Bipyrrole, 4-methoxy-5-((5-methyl-4-pentyl-2H-pyrrol-2-ylidene)m ethyl)- CAS REGISTRY NUMBER : 82-89-3 BEILSTEIN REFERENCE NO. : 4526727 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C20-H25-N3-O MOLECULAR WEIGHT : 323.48 WISWESSER LINE NOTATION : T5NYJ D5 E1 BU1- BT5MJ CO1 E- BT5MJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 18 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #80-162768 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #80-162768

安全

• 安全声明 (欧洲): S26-S36
• 海关编码: 3204151000

海关

海关编码	3204151000