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154-21-2生产厂家

154-21-2价格

相关CAS号：
106536-45-2 954584-09-9
938515-53-8 941950-34-1
121378-73-2 957034-43-4
1104596-34-0 905808-66-4
66787-67-5

154-21-2

154-21-2结构式
154-21-2结构式
  • 常用中文名：林可霉素
  • 常用英文名：Lincomycin
  • CAS号：154-21-2
  • 分子式：C18H34N2O6S
  • 分子量：406.54
  • 相关类别： 原料药 抗生素类药物 林可胺类药
  • 发布时间：2018-02-04 08:00:00
  • 更新时间：2026-07-03 11:00:20
  • 林可霉素盐酸盐为白色结晶性粉末，稍有臭味，味苦。易溶于水。作为抗生素，主要用于治疗鸡的慢性呼吸道疾病和耐青霉素G的金色葡萄球菌和链球菌引起的感染。也能促进鸡肉的生长。

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中文名 林可霉素
英文名 lincomycin
中文别名 甲醇中林可霉素溶液标准物质
克林霉素杂质A
林可黴素
克林霉素磷酸酯杂质A
甲醇中林可霉素
磷酸林可霉素
3-氰基-N-(1
磷酸克林霉素杂质A
盐酸克林霉素杂质A(林可霉素)
磷酸克林霉素杂质 A
洁霉素
克林霉素杂质10(磷酸克林霉素杂质A,盐酸克林霉素杂质A)
甲基6,8-二脱氧-6-[[[(2S,4R)-1-甲基-4-丙基吡咯烷-2YL]羰基]氨基]-1-硫-D-红-Α-D-半乳糖-八吡喃
林可霉素 标准品
6,8-二脱氧-6-(1-甲基-4-丙基-L-2-吡咯烷甲酰氨基)-1-硫代-D-赤式-alpha-D-半乳辛吡喃糖苷
克林霉素杂质A/林可霉素
林可霉素检测标准品
林可霉素Lincomycin
甲醇中林可霉素-D3
林肯霉素
盐酸克林霉素杂质A
抗真菌前体
林可霉素相关杂质
林可霉素-[13C,]三氟乙酸盐/精确称量
林可霉素(碱)
甲醇中林可霉素标准溶液
犬林可霉素前体
3-二苯基吡唑-5-基)苯甲酰胺
(2S,4R)-N-((1R,2R)-2-羟基-1-((2R,3R,4S,5R,6R)-3,4,5-三羟基-6-(甲硫基)四氢-2H-吡喃-2-基)丙基)-1-甲基-4-丙基吡咯烷-2-羧酰胺
英文别名 lincomycina
Methyl 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidinecboxamido)-1-thio-D-erythro-alpha-D-galacto-octopyranoside
(2S,4R)-N-{(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(méthylsulfanyl)tétrahydro-2H-pyran-2-yl]propyl}-1-méthyl-4-propylpyrrolidine-2-carboxamide chlorhydrate
Myvicin
(2S-trans)-Methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-D-threo-a-D-galacto-octopyranoside Hydrochloride
D-erythro-a-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, (2S-trans)
Lincomycine
Clindamycin Phosphate Impurity A （Clindamycin HCl Impurity A）
Methyl 6,8-dideoxy-6-([(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino)-1-thiooctopyranoside
d-erythro-alpha-d-galacto-octopyranoside,methyl6,8-dideoxy-6-(((1-methyl-4-pr
Albiotic
Cillimycin
Lincomycin(baseand/orunspecifiedsalt)
Methyl 6,8-Dideoxy-6-((((2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-D-erythro-a-D-galacto-octopyranoside Monohydrochloride
d-erythro-d-galacto-octopyranoside,methyl-6,8-dideoxy-6-(1-methyl-4-propyl-l-2
Clindamycin Impurity A
LINCOMYCIN
(2S-trans)-Methyl 6,8-Dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-D-erythro-a-D-galactooctopyranoside Monohydrochloride
(2S,4R)-N-{(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)tetrahydro-2H-pyran-2-yl]propyl}-1-methyl-4-propylpyrrolidine-2-carboxamide hydrochloride
Lincomycin (base and/or unspecified salts)
(2S-trans)-Methyl 6,8-Dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl ]amino]-1-thio-D-erythro-α-D-galacto-octopyranoside
LYNCOMYCIN
Clindamycin HCl Impurity A ）
(2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide
Lincomycin,(2S-cis)-Isomer
Methyl-D-erythro-a-D-galacto-octopyranoside
D-erythro-α-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio
Methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-D-erythro-alpha-D-gluco-octopyranoside
Lincomycin hydrochoride
Methyl 6,8-dideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-α-D-galacto-octopyranoside hydrochloride (1:1)
Lincomyocin
U-10149A
d-erythro-d-galacto-octopyranoside,methyl6,8-dideoxy-6-(1-methyl-4-propyl-l-2
Lincolcina
trans-alpha
D-erythro-a-D-galacto-octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, hydrochloride (1:1)
Clindamycin Impurity 10(Clindamycin Phosphate Impurity A
LINCOMYCIN STANDD
methyl 6,8-dideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-a-D-galacto-octopyranoside hydrochloride (1:1)
Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecboxamido)-1-thio-D-erythro-a-D-galactooctopyranoside hydrochloride
Methyl (5R)-5-[(1R,2R)-2-hydroxy-1-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}propyl]-1-thio-β-L-arabinopyranoside hydrochloride (1:1)
Clindamycin Impurity 10（Clindamycin Phosphate）
D-erythro-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecboxamido)-1-thio-, trans-a- (8CI)
methyl 6,8-dideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-α-D-galacto-octopyranoside hydrochloride
(2S,4R)-N-{(1R,2R)-2-Hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)tetrahydro-2H-pyran-2-yl]propyl}-1-methyl-4-propylpyrrolidin-2-carboxamidhydrochlorid
C18H34N2O6S
Lincolnensin
methyl6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecboxamido)-1-thio-d-eryt
Lincomycin HCL Bp98 24 III 2000
D-erythro-a-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio- (9CI)
(2S-trans)-Methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-D-threo-a-D-galacto-octopyranoside
Clindamycin Hydrochloride Impurity A
trans-alpha-pyrrolidinecboxamido)-1-thio
Linocin, Lincolnensin, U 10149, JieMycin
Lincolnensin Hydrochloride
NSC-70731
jiemycin
trans-alpha-opyl-2-pyrrolidinyl)carbonyl)amino)-1-thio
Clindamycin Phosphate Impurities
(2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyl-oxan-2-yl]propyl]-1-methyl-4-propyl-pyrrolidine-2-cboxamide
Clindamycin Phosphate Impurity A
Clindamycin Impurity 10（Clindamycin Phosphate Impurity A，Clindamycin HCl Impurity A ）
Lincocine
UNII-BOD072YW0F
hro-d-galacto-octopyranoside(alpha-form)
Lincomycin hydrochloride
Lincomycin (USAN/INN)
LINCOMYCIN HCL
D-erythro-α-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, hydrochloride (1:1)
Clindamycin Impurity 10
D-erythro-alpha-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, (2S-trans)
EINECS 205-824-6
(2S-trans)-Methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-D-threo-α-D-galacto-octopyranoside Hydrochloride
D-erythro-α-D-galacto-octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, monohydrochloride
Clindamycin Phosphate Impurity A/Lincomycin/(2S,4R)-N-((1R,2R)-2-hydroxy-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-cboxamide
Clindamycin Impurity A (Lincomycine)
U-10149
Lincomycin //BP
Clindamycin Phosphate Impurit A
D-erythro-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecboxamido)-1-thio-, trans- alpha
描述 林可霉素是一种林可酰胺类抗生素,是一种用于革兰氏阳性菌感染研究的抗菌剂[1]。
相关类别
参考文献

[1]. Sasaki E, e al. Construction of the octose 8-phosphate intermediate in lincomycin A biosynthesis: characterization of the reactions catalyzed by LmbR and LmbN. J Am Chem Soc. 2012;134(42):17432-17435.

密度 1.16
沸点 771.9±70.0 °C
熔点 261-263°C
分子式 C18H34N2O6S
分子量 406.54
闪点 345ºC
PSA 147.79000
LogP 0.27380
外观性状 白色结晶固体
折射率 1.6510 (estimate)
储存条件 2-8°C
水溶解性 DMSO: >5 mg/mL at 60 °C
计算化学

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:5

3.氢键受体数量:8

4.可旋转化学键数量:7

5.互变异构体数量:2

6.拓扑分子极性表面积148

7.重原子数量:27

8.表面电荷:0

9.复杂度:499

10.同位素原子数量:0

11.确定原子立构中心数量:9

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1
更多

一、物性数据

1. 性状：不确定。

2. 密度（g/mL,25/4℃）：不确定

3. 相对蒸汽密度（g/mL,空气=1）：不确定

4. 熔点（ºC）：不确定

5. 沸点（ºC,常压）：不确定

6. 沸点（ºC,5.2kPa）：不确定

7. 折射率：不确定

8. 闪点（ºC）：不确定

9. 比旋光度（º）：不确定

10. 自燃点或引燃温度（ºC）：不确定

11. 蒸气压（kPa,25ºC）：不确定

12. 饱和蒸气压（kPa,60ºC）：不确定

13. 燃烧热（KJ/mol）：不确定

14. 临界温度（ºC）：不确定

15. 临界压力（KPa）：不确定

16. 油水（辛醇/水）分配系数的对数值：不确定

17. 爆炸上限（%,V/V）：不确定

18. 爆炸下限（%,V/V）：不确定

19. 溶解性：不确定。

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RH6314000
CHEMICAL NAME :
D-erythro-D-Galacto-octopyranoside, methyl-6,8-dideoxy-6-(1-methyl-4-propyl-L-2- pyrrolidinecarboxamido)-1-thio-, trans-alpha-
CAS REGISTRY NUMBER :
154-21-2
LAST UPDATED :
199706
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C18-H34-N2-O6-S
MOLECULAR WEIGHT :
406.60
WISWESSER LINE NOTATION :
T6OTJ BS1 CQ DQ EQ FYYQ1&MV- BT5NTJ A1 D3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,186,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1900 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Blood - other changes
REFERENCE :
ANKHEW Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. (V/O Me zhdunarodnaya Kniga, 113095 Moskow, USSR) V.33- 1988- Volume(issue)/page/year: 35(2),40,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9778 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
13900 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Blood - other changes
REFERENCE :
ANKHEW Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. (V/O Me zhdunarodnaya Kniga, 113095 Moskow, USSR) V.33- 1988- Volume(issue)/page/year: 35(2),40,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ. Volume(issue)/page/year: -, 554,1962
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RMVEAG Recueil de Medecine Veterinaire. (Masson Pub. USA, Inc., Year Book Medical Pub., 35 E. Wacker Dr., Chicago IL 60601) V.1- 1824- Volume(issue)/page/year: 156,915,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1800 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Blood - other changes
REFERENCE :
ANKHEW Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. (V/O Me zhdunarodnaya Kniga, 113095 Moskow, USSR) V.33- 1988- Volume(issue)/page/year: 35(2),40,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3678 No. of Facilities: 147 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 1414 (estimated) No. of Female Employees: 161 (estimated)

危害码 (欧洲) Xi
RTECS号 DV2037500
海关编码 2941904000
上游产品  0

下游产品  3

链霉菌变异株发酵产生。
海关编码 2941904000
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