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154-21-2

154-21-2 structure
154-21-2 structure
  • Name: Lincomycin
  • Chemical Name: lincomycin
  • CAS Number: 154-21-2
  • Molecular Formula: C18H34N2O6S
  • Molecular Weight: 406.54
  • Catalog: API Antibiotics Lincosamide
  • Create Date: 2018-02-04 08:00:00
  • Modify Date: 2026-07-03 11:00:20
  • Lincomycin, a lincosamide antibiotic, is an antimicrobial agent used for the research of Gram-positive bacteria infections[1].
Name lincomycin
Synonyms lincomycina
Methyl 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidinecboxamido)-1-thio-D-erythro-alpha-D-galacto-octopyranoside
(2S,4R)-N-{(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(méthylsulfanyl)tétrahydro-2H-pyran-2-yl]propyl}-1-méthyl-4-propylpyrrolidine-2-carboxamide chlorhydrate
Myvicin
(2S-trans)-Methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-D-threo-a-D-galacto-octopyranoside Hydrochloride
D-erythro-a-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, (2S-trans)
Lincomycine
Clindamycin Phosphate Impurity A （Clindamycin HCl Impurity A）
Methyl 6,8-dideoxy-6-([(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino)-1-thiooctopyranoside
d-erythro-alpha-d-galacto-octopyranoside,methyl6,8-dideoxy-6-(((1-methyl-4-pr
Albiotic
Cillimycin
Lincomycin(baseand/orunspecifiedsalt)
Methyl 6,8-Dideoxy-6-((((2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-D-erythro-a-D-galacto-octopyranoside Monohydrochloride
d-erythro-d-galacto-octopyranoside,methyl-6,8-dideoxy-6-(1-methyl-4-propyl-l-2
Clindamycin Impurity A
LINCOMYCIN
(2S-trans)-Methyl 6,8-Dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-D-erythro-a-D-galactooctopyranoside Monohydrochloride
(2S,4R)-N-{(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)tetrahydro-2H-pyran-2-yl]propyl}-1-methyl-4-propylpyrrolidine-2-carboxamide hydrochloride
Lincomycin (base and/or unspecified salts)
(2S-trans)-Methyl 6,8-Dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl ]amino]-1-thio-D-erythro-α-D-galacto-octopyranoside
LYNCOMYCIN
Clindamycin HCl Impurity A ）
(2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide
Lincomycin,(2S-cis)-Isomer
Methyl-D-erythro-a-D-galacto-octopyranoside
D-erythro-α-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio
Methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-D-erythro-alpha-D-gluco-octopyranoside
Lincomycin hydrochoride
Methyl 6,8-dideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-α-D-galacto-octopyranoside hydrochloride (1:1)
Lincomyocin
U-10149A
d-erythro-d-galacto-octopyranoside,methyl6,8-dideoxy-6-(1-methyl-4-propyl-l-2
Lincolcina
trans-alpha
D-erythro-a-D-galacto-octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, hydrochloride (1:1)
Clindamycin Impurity 10(Clindamycin Phosphate Impurity A
LINCOMYCIN STANDD
methyl 6,8-dideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-a-D-galacto-octopyranoside hydrochloride (1:1)
Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecboxamido)-1-thio-D-erythro-a-D-galactooctopyranoside hydrochloride
Methyl (5R)-5-[(1R,2R)-2-hydroxy-1-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}propyl]-1-thio-β-L-arabinopyranoside hydrochloride (1:1)
Clindamycin Impurity 10（Clindamycin Phosphate）
D-erythro-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecboxamido)-1-thio-, trans-a- (8CI)
methyl 6,8-dideoxy-6-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}-1-thio-D-erythro-α-D-galacto-octopyranoside hydrochloride
(2S,4R)-N-{(1R,2R)-2-Hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)tetrahydro-2H-pyran-2-yl]propyl}-1-methyl-4-propylpyrrolidin-2-carboxamidhydrochlorid
C18H34N2O6S
Lincolnensin
methyl6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecboxamido)-1-thio-d-eryt
Lincomycin HCL Bp98 24 III 2000
D-erythro-a-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio- (9CI)
(2S-trans)-Methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-D-threo-a-D-galacto-octopyranoside
Clindamycin Hydrochloride Impurity A
trans-alpha-pyrrolidinecboxamido)-1-thio
Linocin, Lincolnensin, U 10149, JieMycin
Lincolnensin Hydrochloride
NSC-70731
jiemycin
trans-alpha-opyl-2-pyrrolidinyl)carbonyl)amino)-1-thio
Clindamycin Phosphate Impurities
(2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyl-oxan-2-yl]propyl]-1-methyl-4-propyl-pyrrolidine-2-cboxamide
Clindamycin Phosphate Impurity A
Clindamycin Impurity 10（Clindamycin Phosphate Impurity A，Clindamycin HCl Impurity A ）
Lincocine
UNII-BOD072YW0F
hro-d-galacto-octopyranoside(alpha-form)
Lincomycin hydrochloride
Lincomycin (USAN/INN)
LINCOMYCIN HCL
D-erythro-α-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, hydrochloride (1:1)
Clindamycin Impurity 10
D-erythro-alpha-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, (2S-trans)
EINECS 205-824-6
(2S-trans)-Methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-D-threo-α-D-galacto-octopyranoside Hydrochloride
D-erythro-α-D-galacto-octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, monohydrochloride
Clindamycin Phosphate Impurity A/Lincomycin/(2S,4R)-N-((1R,2R)-2-hydroxy-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-cboxamide
Clindamycin Impurity A (Lincomycine)
U-10149
Lincomycin //BP
Clindamycin Phosphate Impurit A
D-erythro-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecboxamido)-1-thio-, trans- alpha
Description Lincomycin, a lincosamide antibiotic, is an antimicrobial agent used for the research of Gram-positive bacteria infections[1].
Related Catalog
References

[1]. Sasaki E, e al. Construction of the octose 8-phosphate intermediate in lincomycin A biosynthesis: characterization of the reactions catalyzed by LmbR and LmbN. J Am Chem Soc. 2012;134(42):17432-17435.

Density 1.16
Boiling Point 771.9±70.0 °C
Melting Point 261-263°C
Molecular Formula C18H34N2O6S
Molecular Weight 406.54
Flash Point 345ºC
PSA 147.79000
LogP 0.27380
Index of Refraction 1.6510 (estimate)
Storage condition 2-8°C
Water Solubility DMSO: >5 mg/mL at 60 °C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RH6314000
CHEMICAL NAME :
D-erythro-D-Galacto-octopyranoside, methyl-6,8-dideoxy-6-(1-methyl-4-propyl-L-2- pyrrolidinecarboxamido)-1-thio-, trans-alpha-
CAS REGISTRY NUMBER :
154-21-2
LAST UPDATED :
199706
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C18-H34-N2-O6-S
MOLECULAR WEIGHT :
406.60
WISWESSER LINE NOTATION :
T6OTJ BS1 CQ DQ EQ FYYQ1&MV- BT5NTJ A1 D3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,186,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1900 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Blood - other changes
REFERENCE :
ANKHEW Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. (V/O Me zhdunarodnaya Kniga, 113095 Moskow, USSR) V.33- 1988- Volume(issue)/page/year: 35(2),40,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9778 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
13900 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Blood - other changes
REFERENCE :
ANKHEW Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. (V/O Me zhdunarodnaya Kniga, 113095 Moskow, USSR) V.33- 1988- Volume(issue)/page/year: 35(2),40,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ. Volume(issue)/page/year: -, 554,1962
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RMVEAG Recueil de Medecine Veterinaire. (Masson Pub. USA, Inc., Year Book Medical Pub., 35 E. Wacker Dr., Chicago IL 60601) V.1- 1824- Volume(issue)/page/year: 156,915,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1800 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Blood - other changes
REFERENCE :
ANKHEW Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. (V/O Me zhdunarodnaya Kniga, 113095 Moskow, USSR) V.33- 1988- Volume(issue)/page/year: 35(2),40,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3678 No. of Facilities: 147 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 1414 (estimated) No. of Female Employees: 161 (estimated)
Hazard Codes Xi
RTECS DV2037500
HS Code 2941904000
Precursor  0

DownStream  3

HS Code 2941904000
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