3736-81-0

• 常用中文名：糠酸二氯尼特
• 常用英文名：Diloxanide furoate
• CAS号：3736-81-0
• 分子式：C₁₄H₁₁Cl₂NO₄
• 分子量：328.14700
• 相关类别： 信号通路 抗感染 寄生物
• 发布时间：2018-09-02 22:48:26
• 更新时间：2026-07-23 16:30:59
• Diloxanide furoate是阿米巴病的治疗中使用的腔抗阿米巴药,被认为是治疗轻度肠阿米巴病或无症状囊肿携带者的首选。

名称

• 中文名: 糠酸二氯尼特
• 英文名: [4-[(2,2-dichloroacetyl)-methylamino]phenyl] furan-2-carboxylate
• 中文别名: 糠酸二氟尼特; 4-(2,2-二氯-N-甲基乙酰氨基)苯基 呋喃-2-羧酸酯; 糠二氯散; 二氯尼特糠酸酯; 三呋喃亞甲基二胺; 4-(N-甲基-2,2-二氯乙酰氨基)苯基 2-糠酸酯; 糠酯酰胺; 三糠醛縮二胺
• 英文别名: 2-furoicacid,esterwith2,2-dichloro-4’-hydroxy-n-methylacetanilide; amebiazol; 2-furancboxylicacid,4-((dichloroacetyl)methylamino)phenylester; Diloxanide 2-furoic acid ester; diclofurazol; entamidefuroate; 4-(2,2-Dichloro-N-MethylacetaMido)phenyl furan-2-cboxylate; Entamide 2-furoate; EINECS 223-108-1; [4-[2,2-dichloroethanoyl(methyl)amino]phenyl] furan-2-cboxylate; furamide(amebicide); Diloxanide Furoate; Miforon; furamide; Entamide furoate; 2,2-DICHLORO-N-(4-HYDROXYPHENYL)-N-METHYLACETAMIDE 2-FUROIC ACID ESTER; Diclofurazol; dichlofurazol; Furentomin; Histomibal; furan-2-cboxylic acid [4-[(2,2-dichloroacetyl)-methyl-amino]phenyl] ester; [4-[(2,2-dichloroacetyl)-methylamino]phenyl] furan-2-cboxylate; Amebiazol; MFCD00083302; Furoate; diloxanidfuroate; 2-Furancboxylic acid, 4-[(2,2-dichloroacetyl)methylamino]phenyl ester; entamide2-furoate; Diloxanid furoate; Furamide (amebicide); histomibal; furentomin; DILOXANIDE FUROATE; 8073cb; 4-[(dichloroacetyl)methylamino]phenyl 2-furoate

物化性质

• 分子式: C₁₄H₁₁Cl₂NO₄
• 分子量: 328.14700
• 精确质量: 327.00700
• PSA: 59.75000
• LogP: 3.26530
• 储存条件: 2-8℃

生物活性

• 描述: Diloxanide furoate是阿米巴病的治疗中使用的腔抗阿米巴药,被认为是治疗轻度肠阿米巴病或无症状囊肿携带者的首选。
• 相关类别:
  信号通路 >> 抗感染 >> 寄生物
  研究领域 >> 感染
• 参考文献:

  [1]. Castro Hermida JA, et al. Inhibition of Cryptosporidium infection in mice treated with a cyclodextrin inclusion complex with diloxanide furoate. Parasitol Res. 2001 Jun;87(6):449-52.

  [2]. Martínez-Castillo M, et al. Flavonoids as a Natural Treatment Against Entamoeba histolytica. Front Cell Infect Microbiol. 2018 Jun 22;8:209.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : LV1821800 CHEMICAL NAME : 2-Furoic acid, ester with 2,2-dichloro-4'-hydroxy-N-methylacetanilide CAS REGISTRY NUMBER : 3736-81-0 LAST UPDATED : 198608 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C14-H11-Cl2-N-O4 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 710 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 14,111,1985

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 22
• 安全声明 (欧洲): 36
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: LV1821800