73090-70-7

• 常用中文名：依匹普林
• 常用英文名：EPIROPRIM
• CAS号：73090-70-7
• 分子式：C₁₉H₂₃N₅O₂
• 分子量：353.41800
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2018-03-12 08:00:00
• 更新时间：2024-03-04 08:28:18
• Epiroprim (Ro11-8958) 是一种选择性二氢叶酸还原酶 (DHFR) 抑制剂。Epiroprim 对葡萄球菌、肠球菌、肺炎球菌和链球菌表现出优异的活性。

名称

• 中文名: 依匹普林
• 英文名: 5-[(3,5-diethoxy-4-pyrrol-1-ylphenyl)methyl]pyrimidine-2,4-diamine
• 英文别名: Ro 11-8958; 2,4-Pyrimidinediamine,5-((3,5-diethoxy-4-(1H-pyrrol-1-yl)phenyl)methyl); Epiroprima [INN-Spanish]; 5-((3,5-Diethoxy-4-(1H-pyrrol-1-yl)phenyl)methyl)-2,4-pyrimidinediamine; Epiroprimum [INN-Latin]; Epiroprime [INN-French]; Epiroprim

物化性质

• 密度: 1.27g/cm3
• 沸点: 626.5ºC at 760 mmHg
• 分子式: C₁₉H₂₃N₅O₂
• 分子量: 353.41800
• 闪点: 332.7ºC
• 精确质量: 353.18500
• PSA: 101.21000
• LogP: 3.98230
• 折射率: 1.629

生物活性

• 描述: Epiroprim (Ro11-8958) 是一种选择性二氢叶酸还原酶 (DHFR) 抑制剂。Epiroprim 对葡萄球菌、肠球菌、肺炎球菌和链球菌表现出优异的活性。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. H H Locher, et al. Antibacterial activities of epiroprim, a new dihydrofolate reductase inhibitor, alone and in combination with dapsone. Antimicrob Agents Chemother. 1996 Jun;40(6):1376-81.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UV8140650 CHEMICAL NAME : 2,4-Pyrimidinediamine, 5-((3,5-diethoxy-4-(1H-pyrrol-1-yl)phenyl)methyl)- CAS REGISTRY NUMBER : 73090-70-7 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C19-H23-N5-O2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1419 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia REFERENCE : JCHEEU Journal of Chemotherapy. (Edizioni Riviste Scientifiche, via R. Giuliani, 419, 50141 Florence, Italy) V.1- 1989- Volume(issue)/page/year: 5,400,1993 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JCHEEU Journal of Chemotherapy. (Edizioni Riviste Scientifiche, via R. Giuliani, 419, 50141 Florence, Italy) V.1- 1989- Volume(issue)/page/year: 5,400,1993