206275-15-2

• 常用中文名：CB30865
• 常用英文名：CB30865
• CAS号：206275-15-2
• 分子式：C₂₆H₂₂BrN₅O₂
• 分子量：516.38900
• 相关类别： 信号通路 代谢酶/蛋白酶 NAMPT
• 发布时间：2016-05-31 12:03:34
• 更新时间：2026-06-29 20:57:20
• CB30865(ZM 242421)是Nampt抑制剂。

名称

• 中文名: CB30865
• 英文名: 4-[(7-bromo-2-methyl-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]-N-(pyridin-3-ylmethyl)benzamide
• 中文别名: NAMPT抑制剂(CB30865)
• 英文别名: ZM-242421; Benzamide, 4-[[(7-bromo-3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-2-propyn-1-ylamino]-N-(3-pyridinylmethyl); ZM242421; 4-(((7-bromo-2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl)(prop-2-yn-1-yl)amino)-n-(pyridin-3-ylmethyl)benzamide; 4-[[(7-Bromo-1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-N-(3-pyridinylmethyl)benzamide

物化性质

• 分子式: C₂₆H₂₂BrN₅O₂
• 分子量: 516.38900
• 精确质量: 515.09600
• PSA: 91.24000
• LogP: 4.76200
• 储存条件: 2-8℃

生物活性

• 描述: CB30865(ZM 242421)是Nampt抑制剂。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> NAMPT
  研究领域 >> 癌症
• 参考文献:

  [1]. Lockman JW, et al. Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as potent inhibitors of nicotinamide phosphoribosyltransferase (Nampt). J Med Chem. 2010 Dec 23;53(24):8734-8746.

  [2]. Fleischer TC, et al. Chemical proteomics identifies Nampt as the target of CB30865, an orphan cytotoxic compound. Chem Biol. 2010 Jun 25;17(6):659-664.

  [3]. Bavetsias V, et al. The design and synthesis of water-soluble analogues of CB30865, a quinazolin-4-one-based antitumor agent. J Med Chem. 2002 Aug 15;45(17):3692-3702.

  [4]. Skelton LA, et al. Cell cycle effects of CB30865, a lipophilic quinazoline-based analogue of the antifolate thymidylate synthase inhibitor ICI 198583 with an undefined mechanism of action. Cytometry. 1998 Sep 1;33(1):56-66.