CB30865

• 常用名: CB30865
• 英文名: CB30865
• CAS号: 206275-15-2
• 分子量: 516.38900
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₂BrN₅O₂
• 熔点: N/A
• 闪点: N/A

CB30865用途

CB30865(ZM 242421)是Nampt抑制剂。

CB30865名称

• 中文名: CB30865
• 英文名: 4-[(7-bromo-2-methyl-4-oxo-1H-quinazolin-6-yl)methyl-prop-2-ynylamino]-N-(pyridin-3-ylmethyl)benzamide

CB30865生物活性

• 描述: CB30865(ZM 242421)是Nampt抑制剂。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> NAMPT
  研究领域 >> 癌症
• 参考文献:

  [1]. Lockman JW, et al. Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as potent inhibitors of nicotinamide phosphoribosyltransferase (Nampt). J Med Chem. 2010 Dec 23;53(24):8734-8746.

  [2]. Fleischer TC, et al. Chemical proteomics identifies Nampt as the target of CB30865, an orphan cytotoxic compound. Chem Biol. 2010 Jun 25;17(6):659-664.

  [3]. Bavetsias V, et al. The design and synthesis of water-soluble analogues of CB30865, a quinazolin-4-one-based antitumor agent. J Med Chem. 2002 Aug 15;45(17):3692-3702.

  [4]. Skelton LA, et al. Cell cycle effects of CB30865, a lipophilic quinazoline-based analogue of the antifolate thymidylate synthase inhibitor ICI 198583 with an undefined mechanism of action. Cytometry. 1998 Sep 1;33(1):56-66.

CB30865物理化学性质

• 分子式: C₂₆H₂₂BrN₅O₂
• 分子量: 516.38900
• 精确质量: 515.09600
• PSA: 91.24000
• LogP: 4.76200
• 储存条件: 2-8℃

CB30865靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Growth inhibitory activity against mouse lymphoblastoid L1210TS cell line was determi... 来源：ChEMBL 靶标：Thymidylate synthase External Id：CHEMBL815674

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：NCATS Human Liver Microsomal (HLM) Stability Profiling 来源：NCGC 靶标：N/A External Id：ADME-HLM1

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Growth inhibitory activity against human lymphoblastoid W1L2 cell line 来源：ChEMBL 靶标：WIL2 External Id：CHEMBL821151

实验名称：Inhibition of N-terminal His-tagged human NAMPT 来源：ChEMBL 靶标：Nicotinamide phosphoribosyltransferase External Id：CHEMBL5550322

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CB30865英文别名

• CB30865