17086-76-9

• 常用中文名：杯苋甾酮
• 常用英文名：Cyasterone
• CAS号：17086-76-9
• 分子式：C₂₉H₄₄O₈
• 分子量：520.655
• 相关类别： 生物化工 植物提取物
• 发布时间：2018-09-04 11:12:08
• 更新时间：2026-07-04 16:37:31
• 杯苋甾酮是一种天然的EGFR抑制剂，可通过调节EGFR信号通路抑制A549和MGC823细胞的生长，它可能是一种很有前景的抗癌剂。 杯苋甾酮具有拒食作用。

名称

• 中文名: 杯苋甾酮
• 英文名: cyasterone
• 中文别名: 杯觅甾酮对照品; 杯苋甾酮（Cyasterone）; 杯苋甾酮(杯觅甾酮); 杯苋甾酮(标准品); 杯苋甾酮, 来源于川牛膝; (3S,4S,5R)-4-((2R,3R)-2,3-二羟基-3-((2S,3R,5R,9R,10R,13R,17S)-2,3,14-三羟基- 10,13-二甲基-6-氧代-2,3,4,5,6,9,10,11,12,13,14,15,16,17-十四氢-1H-环戊二烯并[A]菲-17-丁基)-5-羟基-3-甲基四氢-2H-吡喃-2-酮; 杯觅甾酮标准品; 杯苋甾酮(对照品); 杯苋甾酮|||CYASTERON; CYASTERONE 杯苋甾酮; 环阿屯酮; 杯苋甾酮(Cyasterone); 环甾酮; 杯觅甾酮
• 英文别名: Cyasterone(AS); Cyasterone from Cyathula officinalis K.C. Kuan; (2β,3β,5β,23R,24ξ,25S,28R)-2,3,14,20,23-Pentahydroxy-26,28-epoxystigmast-7-ene-6,26-dione; Cyasterone, from Cyathula officinalis K.C. Kuan; cyasteron; 7,(5BETA)-CHOLESTEN-26-CBOXYLIC ACID-24BETA-(1-HYDROXYETHYL)-2BETA, 3BETA, 14ALPHA,20BETA, 22R-PENTOL-6-ONE GAMMA-LACTONE; (2β,3β,5β,22R,24S,25S,28R)-2,3,14,20,22-Pentahydroxy-26,28-epoxystigmast-7-ene-6,26-dione; Cyasteron Cyasterone; CYASTERONE; (3S,4S,5R)-4-[(2R,3R)-2,3-Dihydroxy-3-[(2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-6-oxo-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]butyl]-3,5-dimethyloxolan-2-one; 2-beta,3-beta,14,20,22,28-hexahydroxy-6-oxo-5-beta-stigmast-7-en-26-oicaci; 5β-Stigmast-7-en-26-oic acid, 2β,3β,14,20,22,28-hexahydroxy-6-oxo-, γ-lactone, (22R,24S,25S,28R)-Stigmast-7-en-26-oic acid, 2,3,14,20,22,28-hexahydroxy-6-oxo-, γ-lactone, (2β,3β,5β,22R,24S,25S,28R)-(22r,24s,25s,28r)-gamma-lactoncyasteron; (3S,4S,5R)-4-((2R,3R)-2,3-Dihydroxy-3-((2S,3R,5R,9R,10R,13R,17S)-2,3,14-trihydroxy-10,13-dimethyl-6-oxo-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)butyl)-5-hydroxy-3-methyltetrahydro-2H-pyran-2-one; Stigmast-7-en-26-oic acid, 2,3,14,20,22,28-hexahydroxy-6-oxo-, γ-lactone, (2β,3β,5β,22R,24S,25S,28R); (22R,24S,25S,28R)-2β,3β,14,20,22,28-Hexahydroxy-6-oxo(C)-5β-stigmasta-7-ene-26-oic acid γ-lactone; (22r,24s,25s,28r)-gamma-lacton; Cup amanth steroid

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 742.8±60.0 °C at 760 mmHg
• 分子式: C₂₉H₄₄O₈
• 分子量: 520.655
• 闪点: 242.0±26.4 °C
• 精确质量: 520.303589
• PSA: 144.52000
• LogP: -0.25
• 蒸汽压: 0.0±5.6 mmHg at 25°C
• 折射率: 1.600

生物活性

• 描述: Cyasterone,一种天然的 EGFR 抑制剂,主要分离自 Ajuga decumbens Thunb (Labiatae)。Cyasterone 通过诱导细胞凋亡 (apoptosis) 和细胞周期阻滞表现出抗增殖作用。 Cyasterone 可作为抗人类肿瘤的临床治疗性药物。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> JAK/STAT信号通路 >> EGFR
  信号通路 >> 蛋白酪氨酸激酶 >> EGFR
• 体外研究: 半胱氨酸(0-100μM; 24小时)以浓度和时间依赖性方式抑制细胞生长,A549和MGC823细胞中IC50值分别为38.50 mg/mL,32.96 mg/mL [1]。细胞活力测定[1]细胞系：A549,HCT116,MGC823细胞浓度：0-100μM培养时间：24小时结果：抑制3种人癌细胞系A549,HCT116,MGC823细胞的生长。
• 参考文献:

  [1]. Lu X, et al. Anti-proliferation effects, efficacy of cyasterone in vitro and in vivo and its mechanism. Biomed Pharmacother. 2016 Dec;84:330-339.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : WJ2510000 CHEMICAL NAME : 5-beta-Stigmast-7-en-26-oic acid, 2-beta,3-beta,14,20,22,28-hexahydroxy-6-oxo-, gamma- lactone, (22R,24S,25S,28R)- CAS REGISTRY NUMBER : 17086-76-9 LAST UPDATED : 198909 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C29-H44-O8 MOLECULAR WEIGHT : 520.73 WISWESSER LINE NOTATION : L E5 B666 LV JUTJ IQ OQ PQ FXQ1&YQ1YYQ1&Y1&- CT4OVTJ HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 300 umol/L REFERENCE : NNBYA7 Nature (London), New Biology. (Basingstoke, Hants., UK) V.229-246, 1971-73. For publisher information, see NATUAS. Volume(issue)/page/year: 230,222,1971

安全

• 安全声明 (欧洲): 24/25
• 危险品运输编码: NONH for all modes of transport
• RTECS号: WJ2510000