80418-24-2

• 常用中文名：三七皂苷R1
• 常用英文名：Notoginsenoside R1
• CAS号：80418-24-2
• 分子式：C₄₇H₈₀O₁₈
• 分子量：933.127
• 相关类别： 生物化工 植物提取物
• 发布时间：2018-02-10 08:00:00
• 更新时间：2026-07-01 20:22:04
• 三七皂苷R1 (Notoginsenoside R1) 三七的主要活性成分,据报道有神经保护、抗高血压的作用。

名称

• 中文名: 三七皂甙 R1
• 英文名: notoginsenoside R1
• 中文别名: 三七皂苷R1(分析标准品); 人参皂苷R1; 三七皂苷; 三七皂苷R1(HPLC-UV ,HPLC-ELSD ); 三七皂苷 FB; 三七皂苷R1对照品; 三七根提取物 药典标准 2020; 三七皂甙R1(标准品); 三七皂苷 R1, 来源于三七; NOTOGINSENOSIDE R1 三七皂苷R1; 三七皂苷-FP2; NOTOGINSENOSIDE R1 三七皂苷R1 标准品; (2S,3R,4S,5S,6R)-2-(((S)-2-((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-6-(((2R,3R,4S,5S,6R)-4,5-二羟基-6-(羟甲基)-3-(((2S,3R,4S,5R)-3,4,5-三羟基四氢-2H-吡喃-2-基)氧基)四氢-2H-吡喃-2-基)氧基)-3,12-二羟基-4,4,8,10,14-五甲基十六氢-1H-环戊并[A]菲-17-基)-6-甲基庚-5-烯-2-基)氧基)-6-(羟甲基)四氢-2H-吡喃-3,4,5-三醇; 三七叶提取物 三七叶皂甙; 三七皂苷R1标准品/人参皂苷R1标准品; 抑制剂Notoginsenoside R1; 三七皂苷R1对照品/人参皂苷R1对照品; 三七皂甙R1; 三七皂苷R1,10 MM DMSO 溶液; 4-羧基苯硼酸/4-Cboxyphenylboronic acid; 三七皂苷R1标准品; 三七皂苷R1(人参皂苷R1); 三七皂甙R1(对照品)
• 英文别名: Sanchinoside R1; Sanqi glucoside R1; notogisenoside R1; Notoginsenoside R1 from Panax notoginseng (Burk.)F.H.Chen; (3beta,6alpha,12beta)-20-(beta-D-Glucopyranosyloxy)-3,12-dihydroxydamm-24-en-6-yl 2-O-beta-D-Xylopyranosyl-beta-D-glucopyranoside; β-D-Glucopyranoside, (3β,6α,12β)-20-(β-D-glucopyranosyloxy)-3,12-dihydroxydamm-24-en-6-yl 2-O-β-D-xylopyranosyl; ginsenoside-Rg2; Notoginsenoside R1 Standd; NotoginsenosideR1; Notoginsenoside Fb; TIANFU-CHEM Notoginsenoside R1; Notoginsenoside R1，Sanchinoside R1; (2S,3R,4S,5S,6R)-2-(((S)-2-((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-6-(((2R,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-3,12-dihydroxy-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-methylht-5-en-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; Notoginsenoside R1 Impurity; Notoginseng saponin FP2; Notoginsenoside R1, 10 mM in DMSO; NOTOGINSENOSIDE R1(SH); notoginsenoside Rh1; NOTOGINSENOSIDE; 2-[2-[6-[[4,5-dihydroxy-6-(hydroxymethyl)-3-methyl-2-oxanyl]oxy]-3,12-dihydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylht-5-en-2; NOTOGINSENOSIDE R1; Notoginseng saponin R1; Panax Notoginseng Saponins, PNS; Notoginseng extracts; Notoginsenoside R1-RM; (2S,3R,4S,5S,6R)-2-[(2S)-2-[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-6-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-3,12-dihydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylht-5-en-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol; (3β,6α,12β)-20-(β-D-Glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-β-D-xylopyranosyl-β-D-glucopyranoside; glucopyranosyloxy)-3,12-dihydroxydamm-24-en-6-yl2-O-β-D-xylopyranosyl; Panax notoginseng saponin R1; (3β,6α,12β)-20-(β-D-Glucopyranosyloxy)-3,12-dihydroxydamm-24-en-6-yl 2-O-β-D-xylopyranosyl-β-D-glucopyranoside

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 1010.5±65.0 °C at 760 mmHg
• 熔点: 218 °C
• 分子式: C₄₇H₈₀O₁₈
• 分子量: 933.127
• 闪点: 564.9±34.3 °C
• 精确质量: 932.534485
• PSA: 298.14000
• LogP: 4.42
• 外观性状: white to off-white
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.614
• 储存条件:

  -20°C

• 水溶解性: H2O: soluble1mg/mL, clear, colorless
• 计算化学:

  1.疏水参数计算参考值（XlogP）:1.1

  2.氢键供体数量:12

  3.氢键受体数量:18

  4.可旋转化学键数量:12

  5.互变异构体数量:无

  6.拓扑分子极性表面积298

  7.重原子数量:65

  8.表面电荷:0

  9.复杂度:1670

  10.同位素原子数量:0

  11.确定原子立构中心数量:25

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

生物活性

• 描述: 三七皂苷R1 (Notoginsenoside R1) 三七的主要活性成分,据报道有神经保护、抗高血压的作用。
• 相关类别:
  信号通路 >> 神经信号通路 >> β淀粉样蛋白
  研究领域 >> 其他
  天然产物 >> 萜类化合物和糖苷
• 参考文献:

  [1]. Yang Y, et al. Notoginsenoside R1 reduces blood pressure in spontaneously hypertensive rats through a long non-coding RNA AK094457. Int J Clin Exp Pathol. 2015 Mar 1;8(3):2700-9.

  [2]. Li Zhi, et al. Protective Effect of Notoginsenoside R1 on an APP/PS1 Mouse Model of Alzheimer&aposs Disease by Up-Regulating Insulin Degrading Enzyme and Inhibiting Aβ Accumulation. Protective Effect of Notoginsenoside R1 on an APP/PS1 Mouse Model of Alzh

  [3]. PU Xian-hong, et al. The Effect of Notoginsenoside R1 on TGF-β1/smad3 Signal Pathway in Hepatic Fibrosis Rats. Progress in Modern Biomedicine, 2015-04

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 22
• 安全声明 (欧洲): 24/25
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 29389090