85416-73-5

• 常用中文名：(S)-(+)-咯利普兰
• 常用英文名：S-(+)-Rolipram
• CAS号：85416-73-5
• 分子式：C₁₆H₂₁NO₃
• 分子量：275.343
• 相关类别： 生物化工 抑制剂 代谢(Metabolism) PDE 抑制剂
• 发布时间：2018-06-12 14:26:08
• 更新时间：2024-01-02 09:56:42
• (S)-(+)-Rolipram是cAMP特异的PDE4抑制剂,有抗炎活性,活性小于其R型对映体。

名称

• 中文名: (S)-4-[3-(环戊基氧基)-4-甲氧基苯基]-2-吡咯烷酮
• 英文名: (+)-rolipram
• 中文别名: 盐酸环胞苷; (4S)-4-[3-(环戊基氧基)-4-甲氧基苯基]-2-吡咯烷酮; S- (+)-咯利普兰
• 英文别名: (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone; S2127_Selleck; (4S)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one; 1oyn; S- (+)-Rolipram; 2-Pyrrolidinone, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-, (R)-; S-(+)-Rolipram; (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one; S-(+)-4-(3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidinone; (S)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one; (-)-rolipram; 1xn0; (4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone; (+)-rolipram; (4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one; 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4R)-; 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4S)-; (S)-(+)-Rolipram

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 472.7±45.0 °C at 760 mmHg
• 熔点: 133-136ºC
• 分子式: C₁₆H₂₁NO₃
• 分子量: 275.343
• 闪点: 239.7±28.7 °C
• 精确质量: 275.152130
• PSA: 47.56000
• LogP: 1.43
• 外观性状: 固体;White to Almost white powder to crystal
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.552
• 储存条件: Store at RT

生物活性

• 描述: (S)-(+)-Rolipram是cAMP特异的PDE4抑制剂,有抗炎活性,活性小于其R型对映体。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Griswold, D.E., et al., Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response. Inflammation, 1993. 17(3): p. 333-44.

  [2]. Zhu, J., E. Mix, and B. Winblad, The antidepressant and antiinflammatory effects of rolipram in the central nervous system. CNS Drug Rev, 2001. 7(4): p. 387-98.

  [3]. MacKenzie SJ, et al. Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocyticcells. Biochem J. 2000 Apr

  [4]. Korhonen R, et al. Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1. Br J Pharmacol. 2013 Aug;169(7):1525-36.

安全

• 海关编码: 2933790090

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海关

海关编码	2933790090
中文概述	2933790090 其他内酰胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:9.0% 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%