85416-73-5
85416-73-5 structure
- Name: S-(+)-Rolipram
- Chemical Name: (+)-rolipram
- CAS Number: 85416-73-5
- Molecular Formula: C16H21NO3
- Molecular Weight: 275.343
- Catalog: Biochemical Inhibitor Metabolism PDE inhibitor
- Create Date: 2018-06-12 14:26:08
- Modify Date: 2024-01-02 09:56:42
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(S)-(+)-Rolipram is a PDE4-inhibitor and an anti-inflammatory agent, less potent than its R enantiomer.Target: PDE4B; PDE4DRolipram, a selective inhibitor of the cyclic AMP-specific phosphodiesterase (PDE IV). Rolipram did not inhibit 5-lipoxygenase activity but did inhibit human monocyte production of leukotriene B4 (LTB4, IC50 3.5 microM). Rolipram inhibited arachidonic acid-induced inflammation in the mouse, while the low Km-cyclic-GMP PDE inhibitor. Rolipram had a modest effect on LTB4 production in the mouse, but markedly reduced LTB4-induced PMN infiltration [1]. In humans and animals rolipram produces thereby a variety of biological effects. These effects include attenuation of endogenous depression and inflammation in the central nervous system (CNS), both effects are of potential clinical relevance [2].
| Name | (+)-rolipram |
|---|---|
| Synonyms |
(4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
S2127_Selleck (4S)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one 1oyn S- (+)-Rolipram 2-Pyrrolidinone, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-, (R)- S-(+)-Rolipram (4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one S-(+)-4-(3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidinone (S)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one (-)-rolipram 1xn0 (4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone (+)-rolipram (4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4R)- 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4S)- (S)-(+)-Rolipram |
| Description | (S)-(+)-Rolipram is a PDE4-inhibitor and an anti-inflammatory agent, less potent than its R enantiomer.Target: PDE4B; PDE4DRolipram, a selective inhibitor of the cyclic AMP-specific phosphodiesterase (PDE IV). Rolipram did not inhibit 5-lipoxygenase activity but did inhibit human monocyte production of leukotriene B4 (LTB4, IC50 3.5 microM). Rolipram inhibited arachidonic acid-induced inflammation in the mouse, while the low Km-cyclic-GMP PDE inhibitor. Rolipram had a modest effect on LTB4 production in the mouse, but markedly reduced LTB4-induced PMN infiltration [1]. In humans and animals rolipram produces thereby a variety of biological effects. These effects include attenuation of endogenous depression and inflammation in the central nervous system (CNS), both effects are of potential clinical relevance [2]. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 472.7±45.0 °C at 760 mmHg |
| Melting Point | 133-136ºC |
| Molecular Formula | C16H21NO3 |
| Molecular Weight | 275.343 |
| Flash Point | 239.7±28.7 °C |
| Exact Mass | 275.152130 |
| PSA | 47.56000 |
| LogP | 1.43 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.552 |
| Storage condition | Store at RT |
| HS Code | 2933790090 |
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| Precursor 5 | |
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| DownStream 0 | |
| HS Code | 2933790090 |
|---|---|
| Summary | 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0% |