620112-78-9

• 常用中文名：alpha-[[9-甲基-2-(3-甲基苯氧基)-4-氧代-4H-吡啶并[1,2-a]嘧啶-3-基]亚甲基]-2-苯并噻唑乙腈
• 常用英文名：CCG-63802
• CAS号：620112-78-9
• 分子式：C₂₆H₁₈N₄O₂S
• 分子量：450.51200
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 RGS蛋白质
• 发布时间：2018-12-30 15:50:14
• 更新时间：2026-07-07 19:15:01
• CCG-63802是可逆的G蛋白信号调节子(RGS)抑制剂,对RGS4抑制性尤其高。

名称

• 中文名: alpha-[[9-甲基-2-(3-甲基苯氧基)-4-氧代-4H-吡啶并[1,2-a]嘧啶-3-基]亚甲基]-2-苯并噻唑乙腈
• 英文名: (E)-2-(1,3-benzothiazol-2-yl)-3-[9-methyl-2-(3-methylphenoxy)-4-oxopyrido[1,2-a]pyrimidin-3-yl]prop-2-enenitrile
• 中文别名: ALPHA-[[9-甲基-2-(3-甲基苯氧基)-4-氧代-4H-吡啶并[1,2-A]嘧啶-3-基]亚甲基]-2-苯并噻唑乙腈; CCG-63802试剂; 2-(苯并[D]噻唑-2-基)-3-(9-甲基-4-氧代-2-(间-甲苯氧基)-4H-吡啶并[1,2-A]嘧啶-3-基)丙烯腈; CCG-63802,G蛋白信号传导4(RGS4)蛋白调节剂的抑制剂; RGS抑制剂(CCG-63802)
• 英文别名: unii-339bu4y35u; CCG 63802; CCG63802; (E)-2-(Benzo[d]thiazol-2-yl)-3-(9-methyl-4-oxo-2-(m-tolyloxy)-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylonitrile; CCG-63802,inflammation,RGS,reversible,selective,CCG63802,Regulator of G-protein Signaling,Regulators of G-protein Signaling,inhibit,Inhibitor,CCG 63802,RGS Protein; (E)-2-(Benzo[d]thiazol-2-yl)-3-(9-methyl-4-oxo-2-(m-tolyloxy)-4H-pyrido[1,2-a]pyrimidin-3-yl)acry; α-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile; alpha-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile; (2E)-2-(1,3-Benzothiazol-2-yl)-3-[9-methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]acrylonitrile; (E)-2-(Benzo[d]thiazol-2-yl)-3-(9-methyl-4-oxo-2-(m-tolyloxy)-4H-pyrido[1,2-a]pyrimidin-3-yl)a; 2-Benzothiazoleacetonitrile, α-[[9-methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]; hms1804i11

物化性质

• 密度: 1.31
• 沸点: 547.9ºC at 760 mmHg
• 分子式: C₂₆H₁₈N₄O₂S
• 分子量: 450.51200
• 闪点: 285.1ºC
• 精确质量: 450.11500
• PSA: 108.52000
• LogP: 5.77748
• 折射率: 1.694
• 储存条件: 2-8℃

生物活性

• 描述: CCG-63802是可逆的G蛋白信号调节子(RGS)抑制剂,对RGS4抑制性尤其高。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> RGS蛋白质
  研究领域 >> 癌症
• 参考文献:

  [1]. Blazer LL, et al. Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins. Mol Pharmacol. 2010 Sep;78(3):524-33.

  [2]. Bosier B, et al. Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling. Br J Pharmacol. 2015 Nov;172(22):5333-46.

  [3]. Meng X, et al. PPARγ Agonist PGZ Attenuates OVA-Induced Airway Inflammation and Airway Remodeling via RGS4 Signaling in Mouse Model. Inflammation. 2018 Jul 19.