alpha-[[9-甲基-2-(3-甲基苯氧基)-4-氧代-4H-吡啶并[1,2-a]嘧啶-3-基]亚甲基]-2-苯并噻唑乙腈

更新时间：2025-09-12 12:50:22

alpha-[[9-甲基-2-(3-甲基苯氧基)-4-氧代-4H-吡啶并[1,2-a]嘧啶-3-基]亚甲基]-2-苯并噻唑乙腈结构式	常用名	alpha-[[9-甲基-2-(3-甲基苯氧基)-4-氧代-4H-吡啶并[1,2-a]嘧啶-3-基]亚甲基]-2-苯并噻唑乙腈	英文名	CCG-63802
	CAS号	620112-78-9	分子量	450.51200
	密度	1.31	沸点	547.9ºC at 760 mmHg
	分子式	C₂₆H₁₈N₄O₂S	熔点	N/A
	MSDS	中文版美版	闪点	285.1ºC

用途

CCG-63802是可逆的G蛋白信号调节子(RGS)抑制剂,对RGS4抑制性尤其高。

中文名	alpha-[[9-甲基-2-(3-甲基苯氧基)-4-氧代-4H-吡啶并[1,2-a]嘧啶-3-基]亚甲基]-2-苯并噻唑乙腈
英文名	(E)-2-(1,3-benzothiazol-2-yl)-3-[9-methyl-2-(3-methylphenoxy)-4-oxopyrido[1,2-a]pyrimidin-3-yl]prop-2-enenitrile
英文别名	更多

描述	CCG-63802是可逆的G蛋白信号调节子(RGS)抑制剂,对RGS4抑制性尤其高。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> RGS蛋白质研究领域 >> 癌症
参考文献	[1]. Blazer LL, et al. Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins. Mol Pharmacol. 2010 Sep;78(3):524-33. [2]. Bosier B, et al. Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling. Br J Pharmacol. 2015 Nov;172(22):5333-46. [3]. Meng X, et al. PPARγ Agonist PGZ Attenuates OVA-Induced Airway Inflammation and Airway Remodeling via RGS4 Signaling in Mouse Model. Inflammation. 2018 Jul 19.

描述

CCG-63802是可逆的G蛋白信号调节子(RGS)抑制剂,对RGS4抑制性尤其高。

相关类别

信号通路 >> G 蛋白偶联受体/G 蛋白 >> RGS蛋白质

研究领域 >> 癌症

参考文献

[1]. Blazer LL, et al. Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins. Mol Pharmacol. 2010 Sep;78(3):524-33.

[2]. Bosier B, et al. Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling. Br J Pharmacol. 2015 Nov;172(22):5333-46.

[3]. Meng X, et al. PPARγ Agonist PGZ Attenuates OVA-Induced Airway Inflammation and Airway Remodeling via RGS4 Signaling in Mouse Model. Inflammation. 2018 Jul 19.

密度	1.31
沸点	547.9ºC at 760 mmHg
分子式	C₂₆H₁₈N₄O₂S
分子量	450.51200
闪点	285.1ºC
精确质量	450.11500
PSA	108.52000
LogP	5.77748
InChIKey	VFSVKVQMZDJFQX-NBVRZTHBSA-N
SMILES	Cc1cccc(Oc2nc3c(C)cccn3c(=O)c2C=C(C#N)c2nc3ccccc3s2)c1
折射率	1.694
储存条件	2-8℃

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