256376-24-6

256376-24-6结构式

中文名	BAY 41-2272
英文名	5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-amine
中文别名	BAY 2试剂抑制剂BAY 2 5-环丙基-2-(1-(2-氟苄基)-1H-吡唑并[3,4-B]吡啶-3-基)嘧啶-4-胺 BAY 2,可溶性鸟苷基环化酶(S激活剂 BAY 2,SOLUBLE GUANYLYL CYCLASE (S活化剂
英文别名	BAY 2 (BAY BAY 2, Soluble guanylyl cyclase (s activator 5-cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-amine 5-Cyclopropyl-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-amine 3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine UNII-34A162J6WB Inhibitor,inhibit,Guanylate Cyclase,BAY 41 2272,BAY 412272,BAY 2 5-Cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine BAY 2; 256-6; UNII-34A162J6WB; IN1523; BAY-41-2272; 3-(4-AMINO-5-CYCLOPROPYLPYRIMIDIN-2-YL)-1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3;4-B]PYRIDINE bay-41-2272 4-Pyrimidinamine, 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl] 5-Cyclopropyl-2-[1-[(2-fluorophenyl)Methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyriMidinaMine unii-34a162j6wb BAY 2, 10 mM in DMSO IN1523 3-(4-Amino-5-cyclopropylpyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo[3

描述	BAY 41-2272是一种可溶性鸟苷酸环化酶 (sGC) 活化剂。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 鸟苷酸环化酶研究领域 >> 炎症/免疫
参考文献	[1]. Tuttle TR, et al. The cyclic GMP/protein kinase G pathway as a therapeutic target in head and neck squamous cell carcinoma. Cancer Lett. 2016 Jan 28;370(2):279-85. [2]. Boerrigter G, et al. Cardiorenal and humoral properties of a novel direct soluble guanylate cyclase stimulator BAY 41-2272 in experimental congestive heart failure. Circulation. 2003 Feb 11;107(5):686-9.