3943-97-3

• 常用中文名：4-羟基肉桂酸甲酯
• 常用英文名：Methyl p-coumarate
• CAS号：3943-97-3
• 分子式：C₁₀H₁₀O₃
• 分子量：178.185
• 相关类别： 香精与香料 合成香料 芳香肉桂酸、酯及衍生物
• 发布时间：2018-02-20 08:00:00
• 更新时间：2024-01-02 16:52:20
• Methyl p-coumarate (Methyl 4-hydroxycinnamate),一种从 Trixis michuacana var longifolia 的花中分离出来的对香豆酸 (pCA) 的酯化衍生物。Methyl p-coumarate 可抑制 B16 小鼠黑素瘤细胞中黑色素的形成。Methyl p-coumarate 对链格孢菌和其他病原体也具有很强的体外抑制作用。

名称

• 中文名: 4-羟基肉桂酸甲酯
• 英文名: Methyl 4-hydroxycinnamate
• 中文别名: 对羟基肉桂酸甲酯
• 英文别名: 2-Propenoic acid, 3-(4-hydroxyphenyl)-, methyl ester; p-Hydroxycinnamic acid methyl ester; methyl (2E)-3-(4-hydroxyphenyl)prop-2-enoate; 2-Propenoic acid, 3-(4-hydroxyphenyl)-, methyl ester, (2E)-; Cinnamic acid, p-hydroxy-, methyl ester; EINECS 223-531-1; Methyl 3-(4-hydroxyphenyl)acrylate; Methyl-4-hydroxy cinnamate; Methyl (2E)-3-(4-hydroxyphenyl)acrylate; Methyl 4-hydroxycinnamate; MFCD00157167; 2-Propenoic acid, 3- (4-hydroxyphenyl)-, methyl ester; methyl trans-p-hydroxycinnamate

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 306.6±17.0 °C at 760 mmHg
• 熔点: 144-145ºC
• 分子式: C₁₀H₁₀O₃
• 分子量: 178.185
• 闪点: 132.8±13.7 °C
• 精确质量: 178.062988
• PSA: 46.53000
• LogP: 1.64
• 蒸汽压: 0.0±0.7 mmHg at 25°C
• 折射率: 1.593
• 储存条件: 室温

生物活性

• 描述: Methyl p-coumarate (Methyl 4-hydroxycinnamate),一种从 Trixis michuacana var longifolia 的花中分离出来的对香豆酸 (pCA) 的酯化衍生物。Methyl p-coumarate 可抑制 B16 小鼠黑素瘤细胞中黑色素的形成。Methyl p-coumarate 对链格孢菌和其他病原体也具有很强的体外抑制作用。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 真菌
• 参考文献:

  [1]. Kubo I, et, al. Methyl p-coumarate, a melanin formation inhibitor in B16 mouse melanoma cells. Bioorg Med Chem. 2004 Oct 15;12(20):5349-54.

  [2]. Yuan S, et, al. Defense Responses, Induced by p-Coumaric Acid and Methyl p-Coumarate, of Jujube ( Ziziphus jujuba Mill.) Fruit against Black Spot Rot Caused by Alternaria alternate. J Agric Food Chem. 2019 Mar 13;67(10):2801-2810.

MSDS

Material Safety Data Sheet Section1. Identification of the substance Product Name: Methyl 4-hydroxycinnamate Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:Methyl 4-hydroxycinnamate CAS number:3943-97-3 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Store in closed vessels, refrigerated. Storage: Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data No data Melting point: Flash point:No data Density:No data Molecular formula:C10H10O3 Molecular weight:178.2 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xi
• 海关编码: 2918290000

合成路线

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海关

海关编码	2918290000
中文概述	2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%
申报要素	品名, 成分含量, 用途
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	R.进口食品卫生监督检验 S.出口食品卫生监督检验
Summary	HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%