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3131-52-0生产厂家

3131-52-0价格

3131-52-0

3131-52-0结构式
3131-52-0结构式
  • 常用中文名:5,6-二羟基吲哚
  • 常用英文名:1H-Indole-5,6-diol
  • CAS号:3131-52-0
  • 分子式:C8H7NO2
  • 分子量:149.147
  • 相关类别: 信号通路 抗感染 细菌
  • 发布时间:2018-06-09 20:29:08
  • 更新时间:2024-01-04 10:57:21
  • 5,6-Dihydroxyindole 是一种黑色素的前体,具有广谱抗菌,抗真菌,抗病毒,抗寄生虫活性。5,6-Dihydroxyindole 具有细胞毒性作用,并且对各种病原体具有强毒性。

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中文名 二羟吲哚
英文名 5,6-dihydroxyindole
中文别名 5,6-二羟基吲哚
英文别名 5,6-Dihydroxyindoline
5,6-Dihydroxy-1H-indole
5,6-dihydroxyindol
5,6-Dihydroxyindole
dhi
indole-5,6-diol
Dopamine lutine
Indol-5,6-diol
1H-Indole-5,6-diol
3H-INDOLE-5,6-DIOL
3ID
5,6-dihydroxy-indole
描述 5,6-Dihydroxyindole 是一种黑色素的前体,具有广谱抗菌,抗真菌,抗病毒,抗寄生虫活性。5,6-Dihydroxyindole 具有细胞毒性作用,并且对各种病原体具有强毒性。
相关类别
靶点

Human Endogenous Metabolite

体外研究 5,6-二羟基吲哚(1,10,20,50,100μM;4小时)剂量依赖性地降低OD492值。Sf9细胞经1.0m M 5,6-二羟基吲哚预处理4h后,死亡率为97%,缓冲液中LC50值为20.3μM,培养液中LC50值为131.8μM[1]。用1.25 mM 5,6-二羟基吲哚对杆状病毒进行预培养3小时,几乎完全不能生产重组蛋白。lambda噬菌体的LC50为5.6μM,黄蜂小孢子虫的卵子的LC50为111.0μM。5,6-二羟基吲哚及其自发氧化产物对病毒和寄生蜂也有活性[1]。
参考文献

[1]. Zhao P, et al. Antiviral, anti-parasitic, and cytotoxic effects of 5,6-dihydroxyindole (DHI), a reactive compound generated by phenoloxidase during insect immune response. Insect Biochem Mol Biol. 2011 Sep;41(9):645-52.

[2]. Heiduschka P, et al. Melanin precursor 5,6-dihydroxyindol: protective effects and cytotoxicity on retinal cells in vitroand in vivo. Toxicol Pathol. 2007 Dec;35(7):1030-8.

密度 1.5±0.1 g/cm3
沸点 411.2±25.0 °C at 760 mmHg
分子式 C8H7NO2
分子量 149.147
闪点 202.5±23.2 °C
精确质量 149.047684
PSA 56.25000
LogP 0.37
蒸汽压 0.0±1.0 mmHg at 25°C
折射率 1.802
储存条件 2-8°C
Material Safety Data Sheet

Section1. Identification of the substance
Product Name: 5,6-Dihydroxyindole
Synonyms:

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

Section3. Composition/information on ingredients.
Ingredient name:5,6-Dihydroxyindole
CAS number:3131-52-0

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C8H7NO2
Molecular weight:149.1

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A
危害码 (欧洲) Xn: Harmful;N: Dangerous for the environment;
风险声明 (欧洲) R22
安全声明 (欧洲) 22-26-36/37/39-61
海关编码 2933990090
海关编码 2933990090
中文概述 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%