4434-05-3

• 常用中文名：Notomycin A1
• 常用英文名：COUMERMYCIN AL
• CAS号：4434-05-3
• 分子式：C₅₅H₅₉N₅O₂₀
• 分子量：1110.08000
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2018-02-09 08:00:00
• 更新时间：2026-07-01 18:42:01
• Coumermycin A1 是一种 JAK2 信号激活剂。Coumermycin A1 抑制 DNA 旋转酶 (b>DNA Gyrase),从而抑制细菌的细胞分裂。

名称

• 中文名: 香豆霉素
• 英文名: coumermycin A1
• 中文别名: 香豆毒素A1; 库眉霉素; 库马霉素; 苏哥多霉素; 香豆霉素 A1; 脊霉素
• 英文别名: l)oxy)-4-hydroxy-8-methylcoumin); 1H-Pyrrole-2-cboxylic acid, 5-methyl-, diester with N,N'-bis[7-[(6-deoxy-5-C-methyl-4-o-methyl-.alpha.-L-lyxo-hexopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-3-methyl-1H-pyrrole-2,4-dicboxamide; l)oxy)-4-hydroxy-8-methylcoumarin); Coumermycin A; pyrrole-2-cboxylicacid,5-methyl-,diesterwith3,3’-((3-methylpyrrole-2,4-d; (3R,4S,5R,6R)-5-hydroxy-6-[(4-hydroxy-3-{5-[(4-hydroxy-7-{[(2R,3R,4S,5R)-3-hydroxy-5-methoxy-6,6-dimethyl-4-(5-methyl-1H-pyrrole-2-cbonyloxy)oxan-2-yl]oxy}-8-methyl-2-oxo-2H-chromen-3-yl)cbamoyl]-4-methyl-1H-pyrrole-3-amido}-8-methyl-2-oxo-2H-chromen-7-yl)oxy]-3-methoxy-2,2-dimethyloxan-4-yl 5-methyl-1H-pyrrole-2-cboxylate; coumermycins; Cumamycin; Notomycin; notomycina1; 1H-Pyrrole-2,4-dicboxamide, N2,N4-bis[7-[[6-deoxy-5-C-methyl-4-O-methyl-3-O-[(5-methyl-1H-pyrrol-2-yl)carbonyl]-α-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-3-methyl; N,N'-Bis[7-[[3-O-(5-methyl-1H-pyrrol-2-ylcbonyl)-5-C-methyl-4-O-methyl-6-deoxy-α-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-3-methyl-1H-pyrrole-2,4-dicboxamide; Pyrrole-2-cboxylic acid, 5-methyl-, diester with 3,3'-[(3-methylpyrrole-2,4-diyl)bis(cbonylimino)]bis[7-[(5,5-di-C-methyl-4-o-methyl-.alpha.-L-lyxopyranosyl)oxy]-4-hydroxy-8-methylcoumin]; Sugordomycin D-la; Coumermycin; iyl)bis(cbonylimino))bis(7-((5,5-di-c-methyl-4-o-methyl-alpha-l-lyxopyranosy; COUMERMYCIN A1; coumamycin; Coumermycin A1; NSC-107412

物化性质

• 分子式: C₅₅H₅₉N₅O₂₀
• 分子量: 1110.08000
• 精确质量: 1109.38000
• PSA: 354.89000
• LogP: 5.71790
• 外观性状: 固体
• 储存条件: 2-8°C，密封，干燥

生物活性

• 描述: Coumermycin A1 是一种 JAK2 信号激活剂。Coumermycin A1 抑制 DNA 旋转酶 (b>DNA Gyrase),从而抑制细菌的细胞分裂。
• 相关类别:
  研究领域 >> 代谢疾病
  信号通路 >> 抗感染 >> 细菌
• 体外研究: 古霉素A1诱导的JAK2信号激活增加了SCOS2的mRNA水平,但降低了瘦素受体的mRNA水平[1]。
• 参考文献:

  [1]. Tiantian Zhang, et al. SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepR/JAK2/AMPK Signaling Pathway in Mouse Adipocytes. Research Article.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UX9375000 CHEMICAL NAME : Pyrrole-2-carboxylic acid, 5-methyl-, diester with 3,3'-((3-methylpyrrole-2,4-diyl) bis(carbonylimino))bis(7-((5,5-di-C-methyl-4-O-methyl -alpha-L-lyxopyranosy l)oxy)-4-hydroxy -8-methylcoumarin) CAS REGISTRY NUMBER : 4434-05-3 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C55-H59-N5-O20 MOLECULAR WEIGHT : 1110.19 WISWESSER LINE NOTATION : T66 BOVJ EQ J1 IO- FT6OTJ B1 B1 CO1 EQ DOV- BT5MJ E1&& DMV- DT5M BUTJ C1 BVM- DT66 BOVJ EQ J1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 159 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 200 mg/L REFERENCE : NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 271,385,1978

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 22
• 安全声明 (欧洲): 36
• 危险品运输编码: NONH for all modes of transport
• RTECS号: UX9375000

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