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4434-05-3

4434-05-3 structure
4434-05-3 structure
  • Name: COUMERMYCIN AL
  • Chemical Name: coumermycin A1
  • CAS Number: 4434-05-3
  • Molecular Formula: C55H59N5O20
  • Molecular Weight: 1110.08000
  • Catalog: Signaling Pathways Anti-infection Bacterial
  • Create Date: 2018-02-09 08:00:00
  • Modify Date: 2024-01-09 12:17:47
  • Coumermycin A1 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria.
Name coumermycin A1
Synonyms coumamycin
l)oxy)-4-hydroxy-8-methylcoumarin)
Sugordomycin D-la
Coumermycin
Cumamycin
coumermycins
notomycina1
COUMERMYCIN A1
Notomycin
Description Coumermycin A1 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria.
Related Catalog
In Vitro Coumermycin A1-induced-JAK2 signal activation increases the mRNA level of SCOS2, but reducea leptin receptor mRNA level[1].
References

[1]. Tiantian Zhang, et al. SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepR/JAK2/AMPK Signaling Pathway in Mouse Adipocytes. Research Article.

Molecular Formula C55H59N5O20
Molecular Weight 1110.08000
Exact Mass 1109.38000
PSA 354.89000
LogP 5.71790

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UX9375000
CHEMICAL NAME :
Pyrrole-2-carboxylic acid, 5-methyl-, diester with 3,3'-((3-methylpyrrole-2,4-diyl) bis(carbonylimino))bis(7-((5,5-di-C-methyl-4-O-methyl -alpha-L-lyxopyranosy l)oxy)-4-hydroxy -8-methylcoumarin)
CAS REGISTRY NUMBER :
4434-05-3
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C55-H59-N5-O20
MOLECULAR WEIGHT :
1110.19
WISWESSER LINE NOTATION :
T66 BOVJ EQ J1 IO- FT6OTJ B1 B1 CO1 EQ DOV- BT5MJ E1&& DMV- DT5M BUTJ C1 BVM- DT66 BOVJ EQ J1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
159 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Escherichia coli
DOSE/DURATION :
200 mg/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 271,385,1978
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases 22
Safety Phrases 36
RIDADR NONH for all modes of transport
RTECS UX9375000

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title: CAS No. 4434-05-3 | Chemsrc address: https://m.chemsrc.com/en/baike/402808.html

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