61438-64-0

• 常用中文名：氯氰碘柳胺钠
• 常用英文名：Closantel Sodium
• CAS号：61438-64-0
• 分子式：C₂₂H₁₃Cl₂I₂N₂NaO₂
• 分子量：685.06
• 相关类别： 分析化学 标准品 药典标准品和杂志标准品
• 发布时间：2018-09-25 13:23:13
• 更新时间：2026-07-06 13:17:39
• Closantel钠盐是水杨酰苯胺类驱虫药。
• 本品对牛、羊片形吸虫、捻转血矛线虫以及某些节肢动物均有驱除活性。对前后盘吸虫无效。对多数胃肠道线虫，如血矛线虫、仰口线虫、食道口线虫，驱除率均超过90％。某些羊捻转血矛线虫虫株能对本品产生耐药性。氯氰碘柳胺钠可有效驱除犬钩虫，但对体内的幼虫则无效。还可预防或减少马的普通圆线虫感染。此外，对一、二、三期羊鼻蝇蛆均有100％杀灭效果，对牛皮蝇三期幼虫亦有较好驱杀效果。其抗虫机制是通过增加寄生虫线粒体渗透性，对氧化磷酸化进行解偶联作用，从而发挥驱杀作用。

名称

• 中文名: 氯氰碘柳胺钠
• 英文名: Closantel sodium
• 中文别名: 氯氰碘柳胺钠原料药; 氯氰碘柳胺钠检测标准品; CLOSANTEL钠,抗寄生虫剂; 氯氰柳胺钠(氯氰碘柳胺钠盐); 氯氰柳胺钠盐,氯生太尔; 氯氢碘硫胺钠; 吡硫锌.硫氧吡啶锌; 1氯氰碘柳胺钠; 原料氯氰碘柳胺钠; 氯三醇二水合物钠; 氯氰碘柳胺钠标准品; 氯氰柳胺钠; 氯氰碘柳胺钠 Closantel sodium; N-(5-氯-4-((4-氯苯基)(氰基)甲基)-2-甲基苯基)-2-羟基-3,5-二碘苯甲酰胺钠盐; 氯氰碘柳胺钠·二水合物; 氯氰碘柳胺/用于系统适用性试验/A1A; 1原料氯氰碘柳胺钠; 氯氰碘柳胺钠/A1A; 氯氛碘柳胺钠; 氯氰柳胺钠7.0; 氯氰碘柳胺钠:氯生太尔钠; 氯氰碘柳胺钠原料; 氯氰碘柳胺钠 广谱抗寄生虫; 氯氰碘柳胺纳; 氯氰碘柳胺钠 抗寄生虫病药; 氯生太尔钠; 氯氰碘柳氨钠
• 英文别名: Benzamide, N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodo-, sodium salt (1:1); N-[5-Chloro-4-[(RS)-(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide sodium saltdihydrate; Sodium chlorocyanide iodosamide; Closantel sodiuM,Closantel sodiuM salt,N-[5-Chloro-4-[(chlorophenyl)cyannoMethyl]-2-Methylphenyl]-2-hydroxy-3,5-diiodobenzaMid sodiuM salt; Closantel sodium dihydrate CRS; Clowntel Sodiuni; Chloride sodium cyanide iodine willow amine; EINECS 262-794-7; Closantel SodiumQ: What is Closantel Sodium Q: What is the CAS Number of Closantel Sodium Q: What is the storage condition of Closantel Sodium Q: What e the applications of Closantel Sodium; Closan Sodium; sodium 2-[[5-chloro-4-[(4-chlorophenyl)-cyanomethyl]-2-methylanilino]-oxomethyl]-1-hydroxy-4,6-diiodo-1-cyclohexa-2,4-dienecboxylate; MFCD03427328; losantel sodium; CLOSANTEL(NA); Closan Sodium (Patented); Closantel for system suitability CRS; Closantel (sodium); N-[5-Chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-3,5-diiodo-2-(sodiooxy)benzamide; CLOSANTELUM NATRICUM; Sodium 2-({5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}carbamoyl)-1-hydroxy-4,6-diiodo-2,4-cyclohexadiene-1-carboxylate; 2,4-Cyclohexadiene-1-carboxylic acid, 2-[[[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]amino]carbonyl]-1-hydroxy-4,6-diiodo-, sodium salt (1:1); Benzamide, N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodo-, monosodium salt; sodium N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-o-tolyl]-2-hydroxy-3,5-diiodobenzamidate; N-[5-Chloro-4-[(4-chlorophenyl)cyanoMethyl]-2-Methylphenyl]-2-hydroxy-3,5-diiodo-benzaMide MonosodiuM Salt; Closantel sodium dihydrate (Y0000392); CLOSANTEL SODIUM; n-[5-chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamid sodium salt; N-(5-Chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide, sodium salt; Closantel sodiuni; CLOSANTELSODIUM(PATENTED); closantel sodium salt; Sodium cyanamide chloride

物化性质

• 沸点: 590.5ºC at 760 mmHg
• 熔点: >230ºC (dec.)
• 分子式: C₂₂H₁₃Cl₂I₂N₂NaO₂
• 分子量: 685.06
• 闪点: 310.9ºC
• PSA: 113.25000
• LogP: 4.51228
• 储存条件: Refrigerator

生物活性

• 描述: Closantel钠盐是水杨酰苯胺类驱虫药。
• 相关类别:
  信号通路 >> 抗感染 >> 寄生物
  研究领域 >> 感染
• 参考文献:

  [1]. Bacon JA, et al. Comparative in vitro effects of closantel and selected beta-ketoamide anthelmintics on a gastrointestinal nematode and vertebrate liver cells. J Vet Pharmacol Ther. 1998 Jun;21(3):190-8.

  [2]. Macielag MJ, et al. Substituted salicylanilides as inhibitors of two-component regulatory systems in bacteria. J Med Chem. 1998 Jul 30;41(16):2939-45.

  [3]. Waruiru RM. Efficacy of closantel, albendazole and levamisole on an ivermectin resistant strain of Haemonchus contortus in sheep. Vet Parasitol. 1997 Dec 15;73(1-2):65-71.

安全

• 危害码 (欧洲): Xi
• 海关编码: 2926909090

海关

海关编码	2926909090
中文概述	2926909090 其他腈基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%