51022-69-6

• 常用中文名：安西奈德
• 常用英文名：Amcinonide
• CAS号：51022-69-6
• 分子式：C₂₈H₃₅FO₇
• 分子量：502.57200
• 相关类别： 分析化学 标准品 法医和兽医标准品
• 发布时间：2018-09-22 09:41:18
• 更新时间：2026-07-03 20:23:59
• Amcinonide抑制NO从活化的小胶质细胞释放, IC50 为3.38 nM, 具有糖皮质激素受体亲和力。

名称

• 中文名: 安西奈德
• 英文名: amcinonide
• 中文别名: 安西奈德,10 MM DMSO 溶液; 安西缩松; 2-((6a'S,6b'R,7'S,8a'S,8b'S,11a'R,12a'S,12b'S)-6b'-氟-7'-羟基-6a',8a'-二甲基-4'-氧代-1',2',4',6a',6b',7',8',8a',11a',12',12a',12b'-十二氢-8b'H-螺[环戊烷-1,10'-萘并[2',1':4,5]茚并[1,2-d][1,3]二氧戊环]-8b'-基)-2-氧代乙基 乙酸酯; 甲醇中安西奈德溶液标准物质; 安西奈德溶液, 1000PPM; 安西耐德; 2-((6A'S,6B'R,7'S,8A'S,8B'S,11A'R,12A'S,12B'S)-6B'-氟-7'-羟基-6A',8A'-二甲基-4'-氧代-1',2',4',6A',6B',7',8',8A',11A',12',12A',12B'-十二氢-8B'H-螺[环戊烷-1,10'-萘并[2',1':4,5]茚并[1,2-D][1,3]二氧戊环]-8B'-基)-2-氧代乙基 乙酸酯; 安西奈德溶液,100PPM; 氨米松; 40药典标准; 安西奈德检测标准品; 甲醇中安西奈德标准溶液 100μg/ml; 安西奈德 标准品
• 英文别名: Amcinopol; Amcinonide, 10 mM in DMSO; Amcinonide H0D3460.995mg/mg(ai); 20-dione,21-(acetyloxy)-16,17-(cyclopentylidenebis(oxy))-9-pregna-4-diene-3; Amicla; AMCINONIDE; Ansinede; Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-16,17-[cyclopentylidenebis(oxy)]-9-fluoro-11-hydroxy-, (11β,16α); 2-((6a'S,6b'R,7'S,8a'S,8b'S,11a'R,12a'S,12b'S)-6b'-fluoro-7'-hydroxy-6a',8a'-dimethyl-4'-oxo-2',4',6a',6b',7',8',8a',8b',11a',12',12a',12b'-dodecahydro-1'H-spiro[cyclopentane-1,10'-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxole]-8b'-yl)-2-oxoethyl acetate; Amcinonid; Ann's sinai; (11β,16α)-21-(Acetyloxy)-16,17-[cyclopentylidenebis(oxy)]-9-fluoro-11-hydroxypregna-1,4-diene-3,20-dione; Spiro[cyclopentane-1,8'-[2H]naphth[2',1':4,5]indeno[1,2-d][1,3]dioxole], pregna-1,4-diene-3,20-dione deriv; Penticort; 2-((6a'S,6b'R,7'S,8a'S,8b'S,11a'R,12a'S,12b'S)-6b'-Fluoro-7'-hydroxy-6a',8a'-dimethyl-4'-oxo-1',2',4',6a',6b',7',8',8a',11a',12',12a',12b'-dodecahydro-8b'H-spiro[cyclopentane-1,10'-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxole]-8b'-yl)-2-oxoethyl acetate; Amcinonide Solution, 100ppm; Amciderm; Visderm; Glucocorticoid Rector,CL34699,CL 34699,inhibit,Amcinonide,Inhibitor; (11alpha,16alpha)-21-(Acetyloxy)-16,17-[cyclopentylidenebis(oxy)]-9-fluoro-11-hydroxy-pregna-1,4-diene-3,20-dione; (11-beta,16-alpha)-fluoro-11-hydroxy; cl-34699; cyclocort

物化性质

• 密度: 1.33 g/cm3
• 沸点: 635.9ºC at 760 mmHg
• 分子式: C₂₈H₃₅FO₇
• 分子量: 502.57200
• 闪点: 338.4ºC
• 精确质量: 502.23700
• PSA: 99.13000
• LogP: 3.52380
• 外观性状: 白色至淡黄色粉末
• 折射率: 1.586
• 储存条件: 室温

生物活性

• 描述: Amcinonide抑制NO从活化的小胶质细胞释放, IC50 为3.38 nM, 具有糖皮质激素受体亲和力。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Hong J, et al. Identification and characterization of triamcinolone acetonide, a microglial-activation inhibitor. Immunopharmacol Immunotoxicol. 2012 Dec;34(6):912-918.

  [2]. Berman B, et al. Modulation of expression of epidermal Langerhans cell properties following in situ exposure to glucocorticosteroids. J Invest Dermatol. 1983 Mar;80(3):168-171.

  [3]. Quevedo WC Jr, et al. Influence of depigmenting chemical agents on hair and skin color in yellow (pheomelanic) and black (eumelanic) mice. Pigment Cell Res.1990 Mar-Apr;3(2):71-79.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TU3682500 CHEMICAL NAME : Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-16,17-(cyclopentylidenebis(oxy))-9-flu oro- 11-hydroxy-, (11-beta,16-alpha)- CAS REGISTRY NUMBER : 51022-69-6 LAST UPDATED : 199504 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C28-H35-F-O7 MOLECULAR WEIGHT : 502.63 WISWESSER LINE NOTATION : T F5 E5 B666 GOXO RV AHTTTT&J A1 BF CQ E1 FV1OV1 H-& AL5XTJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,APP-1,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 243 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 13,637,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 145 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 13,637,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,APP-1,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 896 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 13,637,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 143 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 13,637,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9371 No. of Facilities: 13 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 7645 (estimated) No. of Female Employees: 7200 (estimated)

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危害码 (欧洲): Xn
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 2
• RTECS号: TU3682500