338-95-4

• 常用中文名：异氟泼尼松
• 常用英文名：9-fluoroprednisolone
• CAS号：338-95-4
• 分子式：C₂₁H₂₇FO₅
• 分子量：378.435
• 相关类别： 研究领域 其他
• 发布时间：2018-09-29 16:10:33
• 更新时间：2026-07-04 15:58:41
• 异氟哌酮属于皮质类固醇类,通过与动物(如马)的糖皮质激素和盐皮质激素受体结合发挥作用。异氟哌酮可用于多种情况,如感染和炎症性疾病[1]。

名称

• 中文名: 异氟泼尼松
• 英文名: Isoflupredone
• 中文别名: 异氟泼尼松,10 MM DMSO 溶液; 异氟酮; DELTA-FLUOROCORTISONE|||ISOFLUPREDONA|||异氟泼尼松|||ISOFLUPREDONUM|||9-FLUOROPREDNISOLONE; 乙腈中异氟泼尼龙; 甲醇中异氟泼尼松; 倍他米松杂质K; 乙腈中异氟泼尼松溶液,100ΜG/ML; (11Β)-9-氟-11,17,21-三羟基孕甾-1,4-二烯-3,20-二酮; 异氟泼尼松标准品; 氟氢泼尼松; 9氟泼尼松龙; 乙腈中异氟泼尼松; 16H-去甲基地塞米松; 异氟泼尼龙
• 英文别名: Isoflupredone 100 μg/mL in Methanol; ISOFLUPREDONE; Pregna-1,4-diene-3,20-dione, 9-fluoro-11b,17,21-trihydroxy; Isoflupredone in Methanol; 9a-fluoroprednisolone; 1, 4-PREGNADIEN-9α-FLUORO-11β, 17, 21-TRIOL-3, 20-DIONE; Isoflupredone in Acetonitrile; 9α-Fluoro-1-cortisol; Isoflupredone Solution in Acetonitrile, 100μg/mL; Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11b); 1-Dehydro-9a-fluorohydrocortisone; 9α-Fluoroprednisolone; DELTAFLUDROCORTISONE; Isoflupredone, 10 mM in DMSO; 1,4-PREGNADIEN-9ALPHA-FLUORO-11BETA,17ALPHA,21-TRIOL-3,20-DIONE; Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11β); 1,4-PREGNADIEN-9-ALPHA-FLUORO-11-BETA, 17,21-TRIOL-3,20-DIONE; 9-Fluoro-11β,17,21-trihydroxy-pregna-1,4-diene-3,20-dione; 9-FLUOROPREDNISOLONE; (11β)-9-Fluoro-11,17,21-trihydroxypregna-1,4-diene-3,20-dione; Delta-Fluorocortisone|||Isoflupredona|||Isoflupredonum|||9-Fluoroprednisolone; Pregna-1,4-diene-3,20-dione,9-fluoro-11b,17,21-trihydroxy; (11β)-9-Fluoro-11,17,21-trihydroxy-pregna-1,4-diene-3,20-dione; (8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one; (11b)-9-Fluoro-11,17,21-trihydroxypregna-1,4-diene-3,20-dione; 9-Fluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione; 9-ALPHA-FLUOROPREDNISOLONE; Isoflupredone //BP; Isoflupredone 100 μg/mL in Acetonitrile; (8R,9R,10S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 566.7±50.0 °C at 760 mmHg
• 熔点: 274 - 275ºC
• 分子式: C₂₁H₂₇FO₅
• 分子量: 378.435
• 闪点: 296.5±30.1 °C
• 精确质量: 378.184265
• PSA: 94.83000
• LogP: 1.38
• 蒸汽压: 0.0±3.5 mmHg at 25°C
• 折射率: 1.600
• 储存条件: 2~8°C

生物活性

• 描述: 异氟哌酮属于皮质类固醇类,通过与动物(如马)的糖皮质激素和盐皮质激素受体结合发挥作用。异氟哌酮可用于多种情况,如感染和炎症性疾病[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 体内研究: 异氟哌酮显示马的血清钾水平显著降低。异氟哌酮是一种有效的药物,用于治疗反复呼吸道阻塞的马[1]。
• 参考文献:

  [1]. Picandet V, et al. Comparison of efficacy and tolerability of isoflupredone and dexamethasone in the treatment of horses affected with recurrent airway obstruction ('heaves'). Equine Vet J. 2003;35(4):419-424.

安全

• 危害码 (欧洲): Xi

合成路线

338-98-7 ~79% 338-95-4

文献：McLean; Khalil; Heiman; Lee Journal of Pharmaceutical Sciences, 1994 , vol. 83, # 4 p. 476 - 480

514-36-3 ~% 338-95-4

文献：Helvetica Chimica Acta, , vol. 38, p. 1502,1506

52-21-1 ~% 338-95-4

文献：Journal of the American Chemical Society, , vol. 77, p. 4181

4380-55-6 ~% 338-95-4

文献：Journal of the American Chemical Society, , vol. 77, p. 4181

1812-91-5 ~% 338-95-4

文献：Journal of the American Chemical Society, , vol. 77, p. 4181

4224-31-1 ~% 338-95-4

文献：Journal of the American Chemical Society, , vol. 77, p. 4181

38680-83-0 ~% 338-95-4

文献：Journal of the American Chemical Society, , vol. 77, p. 4181

127-31-1 ~% 338-95-4

文献：US2837464 , ; Tetrahedron, , vol. 18, p. 581,588

上下游产品

上游产品  7
338-98-7 514-36-3 52-21-1 4380-55-6
4224-31-1 38680-83-0 127-31-1
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338-98-7 1250-85-7 124-94-7