127-31-1

• 常用中文名：氟氢可的松
• 常用英文名：fludrocortisone
• CAS号：127-31-1
• 分子式：C₂₁H₂₉FO₅
• 分子量：380.450
• 相关类别： 原料药 激素及调节内分泌功能类药 肾上腺皮质激素类药
• 发布时间：2018-07-14 17:21:02
• 更新时间：2024-01-03 21:21:26
• Fludrocortisone是一种合成的盐皮质激素，具有抗炎功能。

名称

• 中文名: 氟氢可的松
• 英文名: fludrocortisone
• 英文别名: Fludrocortone; (11β)-9-Fluoro-11,17,21-trihydroxypregn-4-ene-3,20-dione; 9a-Fluorocortisol; 9α-Fluorocortisol; Alflorone; Fluorocortisone; 9α-Fluoro-11β,17α,21-trihydroxy-4-pregnene-3,20-dione; 9a-Fluorohydrocortisone; Fludrocortisona [INN-Spanish]; Pregn-4-ene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11β)-; MFCD00083333; 9-α-Fluoro-17-hydroxycorticosterone; Fluohydrocortisone; (8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one; Fluorocortisol; Florinef; 9α-Fluoro-17-hydroxycorticosterone; 9-Fluoro-11β,17,21-trihydroxypregn-4-ene-3,20-dione; Astonin-H; 9α-Fludrocortisone; 9a-Fluoro-17-hydroxycorticosterone; Fluohydrisone; (11b)-9-Fluoro-11,17,21-trihydroxypregn-4-ene-3,20-dione; 9-α-Fludrocortisone; EINECS 204-833-2; Fludrone; 9α-Fluorohydrocortisone; fludrocortisone

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 564.7±50.0 °C at 760 mmHg
• 熔点: 208-212ºC
• 分子式: C₂₁H₂₉FO₅
• 分子量: 380.450
• 闪点: 295.3±30.1 °C
• 精确质量: 380.199890
• PSA: 94.83000
• LogP: 1.23
• 外观性状: 白色固体
• 蒸汽压: 0.0±3.5 mmHg at 25°C
• 折射率: 1.584
• 储存条件: Refrigerator
• 分子结构:

  1、 摩尔折射率：95.72

  2、 摩尔体积（cm³/mol）：286.1

  3、 等张比容（90.2K）：786.7

  4、 表面张力（dyne/cm）：57.1

  5、 极化率（10-24cm3）：37.94

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:3

  3.氢键受体数量:6

  4.可旋转化学键数量:2

  5.互变异构体数量:15

  6.拓扑分子极性表面积94.8

  7.重原子数量:27

  8.表面电荷:0

  9.复杂度:734

  10.同位素原子数量:0

  11.确定原子立构中心数量:7

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1.熔点（℃）：208-212。

生物活性

• 描述: Fludrocortisone是一种合成的盐皮质激素,具有抗炎功能。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 盐皮质激素受体
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Jaal J, et al. Small Cell Lung Cancer Patient with Profound Hyponatremia and Acute Neurological Symptoms: An Effective Treatment with Fludrocortisone. Case Rep Oncol Med. 2015;2015:286029.

  [2]. Mori T, et al. Improved efficiency of hypervolemic therapy with inhibition of natriuresis by fludrocortisone in patients with aneurysmal subarachnoid hemorrhage. Journal of Neurosurgery [1999, 91(6):947-952]

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TU5025000 CHEMICAL NAME : Pregn-4-ene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy- CAS REGISTRY NUMBER : 127-31-1 BEILSTEIN REFERENCE NO. : 3014278 LAST UPDATED : 199710 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C21-H29-F-O5 MOLECULAR WEIGHT : 380.50 WISWESSER LINE NOTATION : L E5 B666 OV MUTJ A1 BF CQ E1 FV1Q FQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 170 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Parenteral DOSE : 8750 ug/kg SEX/DURATION : female 7 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : JEMEAV Journal of Experimental Medicine. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1896- Volume(issue)/page/year: 102,347,1955 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 100 mg/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : 28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th International Committee on Laboratory Animals, Hanover, 1972," Speigel, A. ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973 Volume(issue)/page/year: -,85,1973 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1 mg/kg SEX/DURATION : female 13-16 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : 28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th International Committee on Laboratory Animals, Hanover, 1972," Speigel, A. ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973 Volume(issue)/page/year: -,85,1973 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 2 mg/kg SEX/DURATION : female 13-16 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : 28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th International Committee on Laboratory Animals, Hanover, 1972," Speigel, A. ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973 Volume(issue)/page/year: -,85,1973

安全

• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 63
• 安全声明 (欧洲): 22-26-36
• 海关编码: 2937210000

合成路线

514-36-3 ~% 127-31-1

文献：Journal of the American Chemical Society, , vol. 79, p. 1130,1137

566-35-8 ~% 127-31-1

文献：Journal of the American Chemical Society, , vol. 79, p. 1130,1137

7753-60-8 ~% 127-31-1

文献：Journal of the American Chemical Society, , vol. 79, p. 1130,1137

50733-54-5 ~% 127-31-1

文献：Journal of the American Chemical Society, , vol. 79, p. 1130,1137

113862-93-4 ~% 127-31-1

文献：Journal of the American Chemical Society, , vol. 79, p. 1130,1137

4383-30-6 ~% 127-31-1

文献：Journal of the American Chemical Society, , vol. 79, p. 1130,1137

上下游产品

上游产品  6
514-36-3 566-35-8 7753-60-8 50733-54-5
113862-93-4 4383-30-6
下游产品  2
338-95-4 337-02-0

海关

海关编码	2937210000