338-98-7

• 常用中文名：醋酸异氟泼尼松
• 常用英文名：Predef
• CAS号：338-98-7
• 分子式：C₂₃H₂₉FO₆
• 分子量：420.471
• 相关类别： 研究领域 感染
• 发布时间：2018-09-24 13:10:25
• 更新时间：2026-07-01 12:03:08
• 乙酸异氟泼酮是一种具有抗炎活性的皮质类固醇。乙酸异氟泼酮可用于研究牛、马、猪等的酮症、肌肉骨骼疾病、超敏反应、感染和炎症疾病。[1][2]。

名称

• 中文名: 9-氟醋酸泼尼松龙
• 英文名: Isoflupredone Acetate
• 中文别名: 醋酸异氟丙酮; 异氟泼尼松龙醋酸酯; 醋酸异氟泼尼龙; 醋酸异氟泼尼松(醋酸氟氢泼尼松、醋酸异氟泼尼松、异氟泼尼松龙醋酸酯); 醋酸泼尼松龙杂质6; 9氟醋酸泼尼松龙; 醋酸异氟酮; 9-氟泼尼龙醋酸酯,氟泼尼龙醋酸酯; 醋酸异氟泼尼松,10 MM DMSO 溶液; 异氟泼尼龙醋酸酯; 醋酸氟氢泼尼松; 醋酸异氟泼酮
• 英文别名: 21-Acetoxy-9-fluoro-11β,17-dihydroxypregna-1,4-diene-3,20-dione; [2-[(8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate; 9-Fluoro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate; 4-diene-3,20-dione,21-(acetyloxy)-9-fluoro-11,17-dihydroxy-pregna-(11-be; 21-ACETOXY-9-FLUORO-11SS,17-DIHYDROXY-PREGNA-1,4-DIENE-3,20-DIONE; Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-, (11.beta.); 21-acetoxy-9-fluoro-11,17-dihydroxy-pregna-1,4-diene-3,20-dione; U-6013; 21-(Acetyloxy)-9α-fluoro-11β,17α-dihyroxypregna-1,4-diene-3,20-dione; 21-Acetoxy-9-fluoro-11b,17-dihydroxypregna-1,4-dienen-3,20-dione; Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-, (11β); Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-, 21-acetate (8CI); ISOFLUPREDONE ACETATE; 9-Fluoroprednisolone 21-acetate; predef; 9α-Fluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate; 21-Acetoxy-9-fluoro-11,B-17-dihydroxy-pregna-1,4-diene-3,20-dione; Predef R 2X; Isoflupredone Acetate, 10 mM in DMSO; (11b)-9-Fluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl Acetate; Nintedanib Impurity; (11β)-9-Fluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate; 9-fluoroprednisoloneacetate; 9alpha-Fluoro-11beta,17alpha,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate; 4-diene-3,20-dione,9-fluoro-11-beta,17,21-trihydroxy-pregna-21-acetate; 9-fluorprednisoloneacetate; 21-ACETOXY-9-FLUORO-11BETA,17-DIHYDROXY-PREGNA-1,4-DIENE-3,20-DIONE; 9-fluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate; Prednisolone Acetate Impurity 6; IsoflupredineAcetate; isoflupredone 21-acetate; 21-Acetoxy-9-fluoro; biorinil; 1, 4-PREGNADIEN-9α-FLUORO-11β, 17, 21-TRIOL-3, 20-DIONE 21-ACETATE; Pregna-1,4-diene-3,20-dione, 9-fluoro-11-β,17,21-trihydroxy-, 21-acetate; 2-((8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-10,13-diMethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate; Isofluprednisone acetate; 9-Fluoroprednisolone acetate(Isoflupredone acetate); 9-alpha-fluoroprednisoloneacetate; 9-Fluoroprednisolone-21-acetate; Isoflupredone Acetate //BP

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 576.5±50.0 °C at 760 mmHg
• 熔点: 244-246 °C
• 分子式: C₂₃H₂₉FO₆
• 分子量: 420.471
• 闪点: 302.5±30.1 °C
• 精确质量: 420.194824
• PSA: 100.90000
• LogP: 2.46
• 外观性状: 白色到类白色固体
• 蒸汽压: 0.0±3.6 mmHg at 25°C
• 折射率: 1.577
• 储存条件: -20°C

生物活性

• 描述: 乙酸异氟泼酮是一种具有抗炎活性的皮质类固醇。乙酸异氟泼酮可用于研究牛、马、猪等的酮症、肌肉骨骼疾病、超敏反应、感染和炎症疾病。[1][2]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 体外研究: 与高浓度(10-4M)相比,低浓度(10-7M和10-10M)的乙酸异氟泼酮(10-4、10-7或10-10M；48或96h)在更大程度上减轻了滑膜和骨软骨外植体(来自马尸体)中IL-1β的炎症和分解代谢作用[1]。
• 体内研究: 醋酸异氟泼酮(0.05mg/kg；i.m.；激发后第2天和第4天)可防止干物质摄入和平均日增重减少,并在与土霉素(HY-B0275)联合治疗时导致溶血性曼海姆病感染的临床改善更快[2]。动物模型：96头断奶母牛(支气管内输注溶血性曼海姆血症诱导支气管肺炎)[2]剂量：0.05 mg/kg给药：i.m。；结果：感染导致母牛干物质摄入量和平均日增重(ADG)下降。当与土霉素(HY-B0275)联合治疗时,防止了这些减少并导致更快的临床改善。

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TU3970000 CHEMICAL NAME : Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-, 21-acetate CAS REGISTRY NUMBER : 338-98-7 LAST UPDATED : 198910 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C23-H29-F-O6 MOLECULAR WEIGHT : 420.52 WISWESSER LINE NOTATION : L E5 B666 OV AHTTT&J A1 BF CQ E1 FV1OV1 FQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 120 ug/kg SEX/DURATION : female 38 week(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - parturition REFERENCE : JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915- Volume(issue)/page/year: 160,867,1972

安全

• 危险品运输编码: NONH for all modes of transport

合成路线

514-36-3 ~% 338-98-7

文献：Helvetica Chimica Acta, , vol. 39, p. 734,741

40627-86-9 ~0% 338-98-7 3793-90-6

文献：McLean; Khalil; Heiman; Lee Journal of Pharmaceutical Sciences, 1994 , vol. 83, # 4 p. 476 - 480

1812-91-5 ~% 338-98-7

文献：Journal of the American Chemical Society, , vol. 77, p. 4181 Journal of the American Chemical Society, , vol. 77, p. 3166 US2848464 , ;

38680-83-0 ~% 338-98-7

文献：Journal of the American Chemical Society, , vol. 77, p. 4436 Journal of the American Chemical Society, , vol. 77, p. 4181 Journal of the American Chemical Society, , vol. 78, p. 4956,4959

4380-55-6 ~% 338-98-7

文献：Journal of the American Chemical Society, , vol. 77, p. 4181

4224-31-1 ~% 338-98-7

文献：Journal of the American Chemical Society, , vol. 77, p. 4181

52-21-1 ~% 338-98-7

文献：Journal of the American Chemical Society, , vol. 77, p. 4181

338-95-4 ~% 338-98-7

文献：Journal of Pharmaceutical Sciences, , vol. 83, # 4 p. 476 - 480

338-95-4 108-24-7 ~% 338-98-7

文献：Helvetica Chimica Acta, , vol. 38, p. 1502,1506

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