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| 中文名 | 4-氨基-2-甲氧基嘧啶 |
|---|---|
| 英文名 | 2-O-methylcytosine |
| 中文别名 | 2-甲氧基-4-二氨基嘧啶 |
| 英文别名 |
4-Pyrimidinamine, 2-methoxy-
2-Methoxy-4-Pyrimidinamine 2-methoxypyrimidin-4-amine 4-Amino-2-methoxypyrimidine |
| 描述 | 2-O-Methylcytosine,一种 O-烷基化类似物和 DNA 的加合物,属于受损的核碱基。 |
|---|---|
| 相关类别 | |
| 靶点 |
Human Endogenous Metabolite |
| 体外研究 | 受损的碱基会引起DNA突变,导致癌症等多种疾病[1]。 |
| 参考文献 |
| 密度 | 1.2±0.1 g/cm3 |
|---|---|
| 沸点 | 294.4±32.0 °C at 760 mmHg |
| 熔点 | 167-171 °C |
| 分子式 | C5H7N3O |
| 分子量 | 125.129 |
| 闪点 | 131.9±25.1 °C |
| 精确质量 | 125.058914 |
| PSA | 61.03000 |
| LogP | 0.30 |
| 蒸汽压 | 0.0±0.6 mmHg at 25°C |
| 折射率 | 1.567 |
| 储存条件 | 室温， 避光， 惰性气体 |
|
Material Safety Data Sheet
Section1. Identification of the substance Product Name: 4-Amino-2-methoxypyrimidine Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. H302:Harmful if swallowed
H319:Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing Section3. Composition/information on ingredients. Ingredient name:4-Amino-2-methoxypyrimidine CAS number:3289-47-2 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate Eye contact: flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Storage:Store in closed vessels, refrigerated. Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data Melting point:No data Flash point:No data Density:No data Molecular formula:C5H7N3O Molecular weight:125.1 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A |
| 危害码 (欧洲) | Xn |
|---|---|
| 风险声明 (欧洲) | 22-36-36/37/38-20/21/22 |
| 安全声明 (欧洲) | 26-36/37/39 |
| 海关编码 | 2933599090 |
|
~51%
3289-47-2 |
| 文献：Glaxosmithkline LLC; Aubart, Kelly M.; Benowitz, Andrew B.; Fang, Yuhong; Hoffman, James; Karpinski, Joseph M.; Knox, Andrew Nicholson; Liao, Xiangmin; Qin, Donghui; Shi, Dongchuan; Spletstoser, Jared T. Patent: US2013/345120 A1, 2013 ; Location in patent: Page/Page column ; |
|
~%
3289-47-2 |
| 文献：WO2005/49616 A1, ; Page/Page column 80 ; WO 2005/049616 A1 |
|
~%
3289-47-2 |
| 文献：Journal of the American Chemical Society, , vol. 52, p. 1152,1156; vgl. H 24 80 Journal of the American Chemical Society, , vol. 56, p. 190,192 Zhurnal Obshchei Khimii, , vol. 27, p. 2113;engl.Ausg. S.2170 |
|
~%
3289-47-2 |
| 文献：US2008/255172 A1, ; Page/Page column 65 ; |
|
~%
3289-47-2 |
| 文献：Journal of Heterocyclic Chemistry, , vol. 22, p. 149 - 153 |
|
~63%
3289-47-2 |
| 文献：Kimura, Junji; Yagi, Kentaro; Suzuki, Hideyuki; Mitsunobu, Oyo Bulletin of the Chemical Society of Japan, 1980 , vol. 53, # 12 p. 3670 - 3677 |
| 上游产品 5 | |
|---|---|
| 下游产品 4 | |
| 海关编码 | 2933599090 |
|---|---|
| 中文概述 | 2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% |
| 申报要素 | 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期 |
| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
