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64-73-3生产厂家

64-73-3价格

相关CAS号：
1456087-54-9 328897-96-7
1894129-09-9 1785278-70-7
1460324-63-3 1779934-33-6
1290952-21-4 1781021-46-2
1311138-85-8 1781322-53-9

64-73-3

64-73-3结构式
64-73-3结构式

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中文名 地美环素盐酸盐
英文名 demeclocycline hydrochloride
中文别名 地美环素,10 MM DMSO 溶液
地美环素盐酸化物
去甲基金霉素(地美环素)
地美环素盐酸盐/盐酸地美环素/盐酸去甲金霉素
去甲金霉素盐酸盐
地美环素盐酸盐 (-20℃)
去甲金霉素盐酸盐、去甲基氯四环素盐酸盐
盐酸地美环素 标准品
去甲基氯四环素
盐酸脱甲氯环素
去甲金霉素杂质8
地美环素
盐酸去甲基金霉素检测标准品
盐酸地美环素杂质
盐酸金四环素杂质B盐酸盐
地美环素系统适用性 标准品
盐酸去甲基金霉素
去甲金霉素盐酸盐(地美环素)
盐酸去甲金霉素,盐酸地美环素
脱甲氯四环素
地美环素|||DECLOMYCIN|||CLORTETRIN|||盐酸地美环素|||DETRAVIS|||DEMECLOCYCLINE HCL
去甲环素杂质
去甲基金霉素 盐酸地美环素
盐酸去甲金霉素|Demeclocycline hydrochloride
7-氯-4-二甲氨基-3,6,10,12,12a-五羟基-1,11-二氧代-1,4,4a,5,5a,6,11,12a-八氢-2-并四苯甲酰胺盐酸盐
去甲基金霉素(标准品)
盐酸去甲基金霉素(盐酸地美环素)
去甲基金霉素(又名盐酸地美环素)
盐酸去甲金霉素
去甲基金霉素盐酸盐Demeclocycline Hydrochloride
盐酸去甲金霉素,7-氯-4-二甲氨基-3,6,10,12,12A-五羟基-1,11-二氧代-1,4,4A,5,5A,6,11,12A-八氢-2-并四苯甲酰胺盐酸盐
盐酸地美环素/A1A
盐酸地美环素；去甲基金霉素
(4S,4AS,5AS,6S,12AS)-7-氯-4-(二甲胺基)-3,6,10,12,12A-五羟基-1,11-二氧代-1,4,4A,5,5A,6,11,12A-八氢四并苯-2-甲酰胺 盐酸盐
(4S,4AS,5AS,6S,12AS)-7-氯-4-(二甲氨基)-3,6,10,12,12A-五羟基-1,11-二氧代-1,4,4A,5,5A,6,11,12A-八氢并四苯-2-甲酰胺盐酸盐
盐酸去甲金霉素/盐酸金霉素杂质B 标准品
沙瑞环素杂质31
地美环素 盐酸盐 水合物
地美环素杂质
盐酸地美环素杂质8
去甲基金霉素
去甲基金霉素盐酸盐
去甲基金霉素盐酸盐溶液, 100PPM
去甲基金霉素(盐酸米诺环素中间体)
地美环素杂质8
去甲基金霉素盐酸盐标准品
去甲基氯四环素盐酸盐
盐酸去甲金霉素 标准品
地美环素盐酸盐, (HPLC)
英文别名 DemeclocyclineHcl
DeMeclocyline hydrochloride
Demetraciclina
Demeclocycline for system suitability
Demeclocycline HydrochlorideQ: What is Demeclocycline Hydrochloride Q: What is the CAS Number of Demeclocycline Hydrochloride Q: What is the storage condition of Demeclocycline Hydrochloride Q: What e the applications of Demeclocycline Hydrochloride
Declomycin
Demeclocycline Hydrochloride (COLD SHIPMENT REQUIRED)
(4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide,hydrochloride
DEMECLOCYCLIN HYDROCHLORIDE HEMI- HYDRAT
[4S-(4a,4aa,5aa,6b,12aa)]-7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecboxamide Monohydrochloride
declomycinhydrochloride
(4S,4aS,5aS,6S,12aS)-7-chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride
7-chloro-4-dimethylamino-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-cboxamide hydrochloride
HSDB7744
(4S,4aS,5aS,6S,12aS)-7-Chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride (1:1)
Meciclin
DEMECLOCYCLINE HYDROCHLORIDE*CRYSTALLINE
DEMECLOCYCLINE
Demeclocycline hydrochloride //BP
chlorodemethyltetracyclin hydrochloride
Demeclocycline for system suitability CRS
2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, (4S,4aS,5aS,6S,12aS)-, hydrochloride (1:1)
[4S-(4a,4aa,5aa,6,12aa)]-7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecboxamide Monohydrochloride
(4S,4aS,5aS,6S,12aS)-7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-Naphthacenecboxamide, hydrochloride (1:1)
Demeclocycline hydrochloride CRS
Chlortetracycline Hydrochloride Impurity B as Hydrochloride
EINECS 200-592-2
DMCTC
Dimethycline hydrochloride
(4S,4aS,5aS,6S,12aS)-7-chloro-4-(diméthylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotétracène-2-carboxamide chlorhydrate
demeclocycline hydrochloride [INN_en]
Clortetrin
(4S,4aS,5aS,6S,12aS)-7-Chlor-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracen-2-carboxamidhydrochlorid
6-Demethyl-7-chlorotetracycline hydrochloride
Demeclocycline monohydrochloride
6-Demethyl-7-chlorotetracycline Hydrochlorid
DeMeclocycline hydrochlorid
2-Naphthacenecboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, monohydrochloride, (4S,4aS,5aS,6S,12aS)
Mexocine hydrochloride
6-DeMethylchlotetracycline hydrochloride, 7-Chloro-6-deMethyltetracycline hydrochloride, DecloMycin, LederMycin hydrocloride, RP
(4S,4aS,5aS,6S,12aS)-7-chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-cboxamide hydrochloride
Flowmax
Demeclocycline hydrochloride,7-Chloro-6-demethyltetracycline hydrochloride
demethylchlortetracyclinehydrochloride
6,10,12,12a-pentahydroxy-1,11-dioxo-ydro-monohydrochloride
Hnal-D
DeMeclocycline hydrochloride hydrate
2-Naphthacenecboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, monohydrochloride, [4S-(4α,4aα,5aα,6β,12aα)]
Demeclocycline Hydrochloride
2-Naphthacenecboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, monohydrochloride (8CI)
Demeclocyclin hemihydrate hydrochloride
Demeclocycline Impurity 8
MFCD00864922
7-CHLORO-6-DEMETHYLTETRACYCLINE HYDROCHLORIDE
Ledermycin hydrochloride
Demeclocycline hydrochloride, (HPLC)
[4S-(4α,4aα,5aα,6β,12aα)]-7-Chloro-4-(diMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecboxaMide Monohydrochloride
Demeclocycline (hydrochloride)
7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecboxamide monohydrochloride
DemeclocyclineBO
demethylchlorotetracyclinehydrochloride
detravis
(4S,4aS,5aS,6S,12aS)-7-Chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-tetracenecarboxamide hydrochloride (1:1)
2-NaphthacenecboxaMide,7-chloro-4-(diMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-,hydrochloride (1:1), (4S,4aS,5aS,6S,12aS)
HSDB-7744
2-naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, (4S,4aS,5aS,6S,12aS)-, monohydrochloride
Demeclocycline HCl, >=900 μg/mg
描述 Demeclocycline盐酸盐是四环素类抗生素,对莱姆病,粉刺和支气管炎有效。
相关类别
沸点 795.9ºC at 760 mmHg
熔点 >245°C (dec.)
分子式 C21H22Cl2N2O8
分子量 501.314
闪点 435.2ºC
精确质量 500.075317
PSA 181.62000
LogP 1.76720
外观性状 黄色固体
储存条件

本品应密封于阴凉干燥处避光保存。

水溶解性 H2O: 20 mg/mL, clear, very deep greenish yellow
计算化学

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:7

3.氢键受体数量:9

4.可旋转化学键数量:2

5.互变异构体数量:132

6.拓扑分子极性表面积182

7.重原子数量:33

8.表面电荷:0

9.复杂度:961

10.同位素原子数量:0

11.确定原子立构中心数量:5

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:2
更多

1. 性状：粉状

2. 密度（g/mL,25/4℃）：不确定

3. 相对蒸汽密度（g/mL,空气=1）：不确定

4. 熔点（ºC）：> 245°C (dec.)

5. 沸点（ºC,常压）：不确定

6. 沸点（ºC, 5.2kPa）：不确定

7. 折射率：不确定

8. 闪点（ºC）：不确定

9. 比旋光度（º）：不确定

10. 自燃点或引燃温度（ºC）：不确定

11. 蒸气压（kPa,25ºC）：不确定

12. 饱和蒸气压（kPa,60ºC）：不确定

13. 燃烧热（KJ/mol）：不确定

14. 临界温度（ºC）：不确定

15. 临界压力（KPa）：不确定

16. 油水（辛醇/水）分配系数的对数值：不确定

17. 爆炸上限（%,V/V）：不确定

18. 爆炸下限（%,V/V）：不确定

19. 溶解性：H2O: 20mg/mL, clear, very deep greenish yellow

毒理学数据:

急性毒性：人口经 LDLo ： 69 mg/kg/4D-I ；大鼠口经 LD50 ： 2372 mg/kg ；大鼠静脉LD50：94 mg/kg； 小鼠口经LD50：2150 mg/kg；小鼠静脉LD50：275 mg/kg； 繁殖：大鼠子宫TDLo：50 mg/kgSEX/DURATION : female 1 day(s) pre-mating； 妇女途径未知TDLo：48 ug/kgSEX/DURATION : female 28 week(s) after conception；

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QI7700000
CHEMICAL NAME :
2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octah ydro- 3,6,10,12,12a-pentahydroxy-1,11-dioxo-, monohydrochloride
CAS REGISTRY NUMBER :
64-73-3
LAST UPDATED :
199706
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C21-H21-Cl-N2-O8.Cl-H
MOLECULAR WEIGHT :
501.35
WISWESSER LINE NOTATION :
L E6 C666 BV FV CU GUTTT&J DQ EQ GVZ HQ IN1&1 MQ OG RQ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
69 mg/kg/4D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - renal function tests depressed Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
AJKDDP American Journal of Kidney Diseases. (Grune & Stratton, Inc., Journal Subscription Dept., POB 6280, Duluth, MN 55806) V.1- 1981- Volume(issue)/page/year: 5,270,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2372 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
94 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,704,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,704,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
275 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AISMAE Archivio Italiano di Scienze Mediche Tropical e di Parassitologia. Italian Archives of the Science of Tropical Medicine and Parasitology. (Rome, Italy) V.1-54, 1920-73. Suspended. Volume(issue)/page/year: 43,143,1962 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
48 ug/kg
SEX/DURATION :
female 28 week(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034, Evanston, IL 60204) V.1- 1948- Volume(issue)/page/year: 34,423,1964
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intrauterine
DOSE :
50 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 29,553,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4830 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 291 (estimated) No. of Female Employees: 129 (estimated)

符号 GHS07
GHS07
信号词 Warning
危害声明 H317
警示性声明 P280
个人防护装备 dust mask type N95 (US);Eyeshields;Faceshields;Gloves
危害码 (欧洲) Xi:Irritant;
风险声明 (欧洲) R43
安全声明 (欧洲) S36/37
危险品运输编码 NONH for all modes of transport
WGK德国 2
RTECS号 QI7700000
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