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盐酸地美环素

更新时间:2024-01-03 19:41:59

盐酸地美环素结构式
盐酸地美环素结构式
品牌特惠专场
常用名 盐酸地美环素 英文名 Demeclocycline hydrochloride
CAS号 64-73-3 分子量 501.314
密度 N/A 沸点 795.9ºC at 760 mmHg
分子式 C21H22Cl2N2O8 熔点 >245°C (dec.)
MSDS 中文版 美版 闪点 435.2ºC
符号 GHS07
GHS07
信号词 Warning

 盐酸地美环素用途


Demeclocycline盐酸盐是四环素类抗生素,对莱姆病,粉刺和支气管炎有效。

 盐酸地美环素名称

中文名 地美环素盐酸盐
英文名 demeclocycline hydrochloride
中文别名 盐酸去甲金霉素 | 盐酸地美环素 | 盐酸去甲基金霉素
英文别名 更多

 盐酸地美环素生物活性

描述 Demeclocycline盐酸盐是四环素类抗生素,对莱姆病,粉刺和支气管炎有效。
相关类别

 盐酸地美环素物理化学性质

沸点 795.9ºC at 760 mmHg
熔点 >245°C (dec.)
分子式 C21H22Cl2N2O8
分子量 501.314
闪点 435.2ºC
精确质量 500.075317
PSA 181.62000
LogP 1.76720
外观性状 黄色固体
储存条件

本品应密封于阴凉干燥处避光保存。

水溶解性 H2O: 20 mg/mL, clear, very deep greenish yellow
计算化学

1.疏水参数计算参考值(XlogP):无

2.氢键供体数量:7

3.氢键受体数量:9

4.可旋转化学键数量:2

5.互变异构体数量:132

6.拓扑分子极性表面积182

7.重原子数量:33

8.表面电荷:0

9.复杂度:961

10.同位素原子数量:0

11.确定原子立构中心数量:5

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:2

更多

1. 性状:粉状

2. 密度(g/mL,25/4℃):不确定

3. 相对蒸汽密度(g/mL,空气=1):不确定

4. 熔点(ºC):> 245°C (dec.)

5. 沸点(ºC,常压):不确定

6. 沸点(ºC, 5.2kPa):不确定

7. 折射率:不确定

8. 闪点(ºC):不确定

9. 比旋光度(º):不确定

10. 自燃点或引燃温度(ºC):不确定

11. 蒸气压(kPa,25ºC):不确定

12. 饱和蒸气压(kPa,60ºC):不确定

13. 燃烧热(KJ/mol):不确定

14. 临界温度(ºC):不确定

15. 临界压力(KPa):不确定

16. 油水(辛醇/水)分配系数的对数值:不确定

17. 爆炸上限(%,V/V):不确定

18. 爆炸下限(%,V/V):不确定

19. 溶解性:H2O: 20mg/mL, clear, very deep greenish yellow

 盐酸地美环素毒性和生态

盐酸地美环素毒理学数据:

急性毒性:人口经 LDLo : 69 mg/kg/4D-I ;大鼠口经 LD50 : 2372 mg/kg ;大鼠静脉LD50:94 mg/kg; 小鼠口经LD50:2150 mg/kg;小鼠静脉LD50:275 mg/kg; 繁殖:大鼠子宫TDLo:50 mg/kgSEX/DURATION : female 1 day(s) pre-mating; 妇女途径未知TDLo:48 ug/kgSEX/DURATION : female 28 week(s) after conception;

盐酸地美环素毒性英文版

 盐酸地美环素安全信息

符号 GHS07
GHS07
信号词 Warning
危害声明 H317
警示性声明 P280
个人防护装备 dust mask type N95 (US);Eyeshields;Faceshields;Gloves
危害码 (欧洲) Xi:Irritant;
风险声明 (欧洲) R43
安全声明 (欧洲) S36/37
危险品运输编码 NONH for all modes of transport
WGK德国 2
RTECS号 QI7700000

 盐酸地美环素文献33

更多文献
Pre-microRNA binding aminoglycosides and antitumor drugs as inhibitors of Dicer catalyzed microRNA processing.

Bioorg. Med. Chem. Lett. 22 , 1709-11, (2012)

Over-expressions of miRNAs are being increasingly linked with many diseases including different types of cancer. In this study, the role of some known small molecular therapeutics has been investigate...

Developing structure-activity relationships for the prediction of hepatotoxicity.

Chem. Res. Toxicol. 23 , 1215-22, (2010)

Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...

A predictive ligand-based Bayesian model for human drug-induced liver injury.

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Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti...

 盐酸地美环素英文别名

2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, (4S,4aS,5aS,6S,12aS)-, hydrochloride (1:1)
Ledermycin hydrochloride
EINECS 200-592-2
Demeclocycline hydrochloride
(4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide,hydrochloride
(4S,4aS,5aS,6S,12aS)-7-chloro-4-(diméthylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotétracène-2-carboxamide chlorhydrate
demeclocycline hydrochloride [INN_en]
(4S,4aS,5aS,6S,12aS)-7-Chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-tetracenecarboxamide hydrochloride (1:1)
(4S,4aS,5aS,6S,12aS)-7-chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride
(4S,4aS,5aS,6S,12aS)-7-Chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride (1:1)
(4S,4aS,5aS,6S,12aS)-7-Chlor-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracen-2-carboxamidhydrochlorid
2-naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, (4S,4aS,5aS,6S,12aS)-, monohydrochloride
MFCD00864922
Demeclocycline (hydrochloride)
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