132-92-3

• 常用中文名：甲氧西林钠
• 常用英文名：Methicillin SodiuM
• CAS号：132-92-3
• 分子式：C₁₇H₁₉N₂NaO₆S
• 分子量：402.39700
• 相关类别： 原料药 抗生素类药物 青霉素类药
• 发布时间：2018-05-27 08:00:00
• 更新时间：2024-01-02 18:39:17
• Methicillin是β-内酰胺抗生素,其通过抑制参与肽聚糖合成的青霉素结合蛋白起作用。

名称

• 中文名: 甲氧西林钠
• 英文名: methicillin sodium
• 英文别名: (2S,5R,6R)-6-[(2,6-Dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt; Methicillin sodium salt; Methicillin Sodium; meticillin sodium; sodium 6-(2,6-dimethoxybenzamido)penicillanate; EINECS 205-083-9; MFCD07787409; Sodium (2,6-dimethoxyphenyl)penicillin,Sodium methicillin

物化性质

• 沸点: 640ºC at 760 mmHg
• 熔点: 196-197℃
• 分子式: C₁₇H₁₉N₂NaO₆S
• 分子量: 402.39700
• 闪点: 340.9ºC
• 精确质量: 402.08600
• PSA: 133.30000
• 外观性状: white to off-white
• 蒸汽压: 2.94E-17mmHg at 25°C
• 储存条件: 2-8°C
• 水溶解性: Slightly soluble in acetone. Soluble in ethanol or water
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:1

  3.氢键受体数量:7

  4.可旋转化学键数量:5

  5.互变异构体数量:4

  6.拓扑分子极性表面积133

  7.重原子数量:27

  8.表面电荷:0

  9.复杂度:606

  10.同位素原子数量:0

  11.确定原子立构中心数量:3

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:2

生物活性

• 描述: Methicillin是β-内酰胺抗生素,其通过抑制参与肽聚糖合成的青霉素结合蛋白起作用。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : XH8950000 CHEMICAL NAME : 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(2,6-dimethoxybenzamido)-3,3-dimethyl- 7-oxo-, monosodium salt CAS REGISTRY NUMBER : 132-92-3 LAST UPDATED : 199709 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C17-H19-N2-O6-S.Na MOLECULAR WEIGHT : 402.43 WISWESSER LINE NOTATION : T45 ANV ESTJ CMVR BO1 FO1& F1 F1 GVO &-NA- HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - child DOSE/DURATION : 600 mg/kg/3D TOXIC EFFECTS : Liver - other changes Blood - leukopenia Blood - eosinophilia REFERENCE : AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960- Volume(issue)/page/year: 135,52,1981 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 17,70,1961 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 17,70,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,826,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >2500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ. Volume(issue)/page/year: -,619,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,826,1982 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4 gm/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Cardiac - other changes Lungs, Thorax, or Respiration - other changes REFERENCE : BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 17,70,1961 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4186 No. of Facilities: 272 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 11353 (estimated) No. of Female Employees: 7943 (estimated)

安全

• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): 36/37/38-42/43
• 安全声明 (欧洲): 26-36
• RTECS号: XH8950000