5714-00-1

• 常用中文名：二马来酸乙酰奋乃静
• 常用英文名：ACETOPHENAZINE
• CAS号：5714-00-1
• 分子式：C₂₇H₃₃N₃O₆S
• 分子量：527.63200
• 相关类别： 分析化学 标准品 药典标准品和杂志标准品
• 发布时间：2018-07-28 22:33:12
• 更新时间：2024-01-02 14:13:55
• Acetophenazine dimaleate 是一种抗精神病试剂,对焦虑抑郁有效。

名称

• 中文名: 二马来酸乙酰奋乃静
• 英文名: acetophenazine dimaleate
• 中文别名: 10-[3-[4-(2-羟乙基)-10哌嗪)丙基]吩噻嗪-2-基甲酮马来酸盐
• 英文别名: sch6673; acetophenazinemaleate; Ethanone, 1-[10-[3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl]-10H-phenothiazin-2-yl]-, (Z) 2-butenedioate (1_2) (salt); Acetophazine maleate; ACETOPHENZAINEMALEATE; tindal; Acetophenazine dimaleate

物化性质

• 沸点: 608.7ºC at 760 mmHg
• 熔点: 167-168.5°
• 分子式: C₂₇H₃₃N₃O₆S
• 分子量: 527.63200
• 闪点: 321.9ºC
• 精确质量: 527.20900
• PSA: 146.92000
• LogP: 3.14450
• 储存条件: 通风低温干燥,与库房食品原料分开存放

生物活性

• 描述: Acetophenazine dimaleate 是一种抗精神病试剂,对焦虑抑郁有效。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Hollister LE, et al. Acetophenazine and diazepam in anxious depressions. Arch Gen Psychiatry. 1971 Mar;24(3):273-8.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : OB4180000 CHEMICAL NAME : Ketone, 10-(3-(4-(2-hydroxyethyl)-1-piperazinyl)propyl)phenot hiazin-2-yl methyl, dimaleate CAS REGISTRY NUMBER : 5714-00-1 LAST UPDATED : 199706 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C23-H29-N3-O2-S.2C4-H4-O4 MOLECULAR WEIGHT : 643.77 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit REFERENCE : AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 14,250,1956 ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 415 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,11,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 60 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,11,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 39 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,11,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 71 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01100 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - wild bird species DOSE/DURATION : 75 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972 *** REVIEWS *** TOXICOLOGY REVIEW IDPYAK Industrial Pharmacology. (Mount Kisco, NY) V.1-3, 1974-79. Discontinued. Volume(issue)/page/year: 1,203,1974

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H319
• 警示性声明: P305 + P351 + P338
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 36
• 安全声明 (欧洲): 26
• 危险品运输编码: NONH for all modes of transport
• RTECS号: OB4180000