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6882-68-4生产厂家

6882-68-4价格

6882-68-4

6882-68-4结构式
6882-68-4结构式
  • 常用中文名:槐定碱
  • 常用英文名:Sophoridine
  • CAS号:6882-68-4
  • 分子式:C15H24N2O
  • 分子量:248.364
  • 相关类别: 生物化工 中草药成分
  • 发布时间:2018-08-19 11:42:13
  • 更新时间:2024-01-08 11:12:21
  • Sophoridine 是一种从豆科植物槐豆斜生植物的叶子中分离出来的喹喔啉生物碱。Sophoridine 诱导细胞凋亡 (apoptosis)。Sophoridine 有可能成为胰腺癌的有效,选择性和耐受性良好的候选药物。

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中文名 槐定碱
英文名 Sophoridine
英文别名 1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, dodecahydro-, (7aR,13aR,13bR,13cS)-
Allomatrine
(5β)-Matridin-15-one
Bio-0637
5-Epidihydrosophocarpine
Dihydro-5-episophocarpine
(7aR,13aR,13bR,13cS)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one
sophoridine
matridin-15-one
描述 Sophoridine 是一种从豆科植物槐豆斜生植物的叶子中分离出来的喹喔啉生物碱。Sophoridine 诱导细胞凋亡 (apoptosis)。Sophoridine 有可能成为胰腺癌的有效,选择性和耐受性良好的候选药物。
相关类别
体外研究 槐角苷(0-500μM;48小时)对人胰腺癌,胃癌,肝癌,结肠癌,胆囊癌和前列腺癌细胞的生长具有显着的抑制作用,IC50值约为20μM至200μM[1]。Sophoridine(0-20μM;48小时)使Miapaca-2细胞中S期细胞群从26.23%(对照)增加到38.67%,PANC-1细胞从29.56%(对照)增加到39.16%,约为1.5倍和分别增加1.3倍[1]。槐角苷(0-20μM;48小时)显着增加bad和bax水平,并降低bcl-2和bcl-xl水平,而bax/bcl-2比率显着增加[1]。细胞活力测定[1]细胞系:正常细胞:IOSE144,HL-7702和LO2,BEAS-2B,GES-1,HEK 293 T,HPDE,FHC,人癌细胞:PANC-1,Mapaca-1,hepG2,SGC-7901,CBC-SD,SGC-996,PC-3,MKN-45,MGC-803,Hela和HCT116细胞浓度:0,3.9,7.8,15.5,31,62.5,125,250,500μM孵育时间:48小时结果:对癌细胞表现出最有效的细胞毒性。细胞周期分析[1]细胞系:PANC-1细胞;Miapca-2细胞浓度:20μM孵育时间:48小时结果:导致S期累积群体。蛋白质印迹分析[1]细胞系:PANC-1细胞;Miapca-2细胞浓度:20μM孵育时间:48小时结果:诱导内源性凋亡途径的激活。
体内研究 槐角苷(腹腔注射;20或40 mg/kg;21天)可抑制异种移植胰腺肿瘤的生长[1]。动物模型:BALB/c纯合(nu/nu)裸鼠[1]剂量:20或40mg/kg给药:腹膜内注射;20或40mg/kg;21天结果:异种移植胰腺肿瘤质量减少。
参考文献

[1]. Xu Z, et al. Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells. J Exp Clin Cancer Res. 2017 Sep 11;36(1):124.

密度 1.2±0.1 g/cm3
沸点 396.7±31.0 °C at 760 mmHg
熔点 109 °C
分子式 C15H24N2O
分子量 248.364
闪点 172.7±17.2 °C
精确质量 248.188858
PSA 23.55000
LogP 1.44
外观性状 固体;White to Light yellow powder to crystal
蒸汽压 0.0±0.9 mmHg at 25°C
折射率 1.581
储存条件 0-10°C;避免加热

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WG1250000
CHEMICAL NAME :
Sophoridine
CAS REGISTRY NUMBER :
6882-68-4
LAST UPDATED :
199412
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C15-H24-N2-O
MOLECULAR WEIGHT :
248.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
243 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 27,201,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
64300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 8,153,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
46800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YFZADL Yaowu Fenxi Zazhi. Journal of Pharmaceutical Analysis. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1981- Volume(issue)/page/year: 6,96,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
350 mg/kg/35D-I
TOXIC EFFECTS :
Blood - changes in leukocyte (WBC) count
REFERENCE :
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 8,153,1987

危害码 (欧洲) Xi
安全声明 (欧洲) 24/25