Sophoridine

Modify Date: 2024-01-08 11:12:21

Sophoridine Structure
Sophoridine structure
 Common Name Sophoridine
CAS Number 6882-68-4 Molecular Weight 248.364
Density 1.2±0.1 g/cm3 Boiling Point 396.7±31.0 °C at 760 mmHg
Molecular Formula C15H24N2O Melting Point 109 °C
MSDS N/A Flash Point 172.7±17.2 °C

 Use of Sophoridine


Sophoridine is a quinolizidine alkaloid isolated from leafs of Leguminous plant Sophora alopecuroides.L. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor drug candidate for pancreatic cancer with well-tolerated toxicity[1].

 Names

Name Sophoridine
Synonym More Synonyms

 Sophoridine Biological Activity

Description Sophoridine is a quinolizidine alkaloid isolated from leafs of Leguminous plant Sophora alopecuroides.L. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor drug candidate for pancreatic cancer with well-tolerated toxicity[1].
Related Catalog
In Vitro Sophoridine (0-500 μM; 48 hours) exhibits remarkable inhibition effects to the growth of human pancreatic, gastric, liver, colon, gallbladder, and prostate carcinoma cells with IC50 values of about 20 μM to 200 μM[1]. Sophoridine (0-20 μM; 48 hours) increases S phase cell population from 26.23% (control) to 38.67% in Miapaca-2 cells and from 29.56% (control) to 39.16% in PANC-1 cells, about a 1.5-fold and a 1.3-fold increase, respectively[1]. Sophoridine (0-20 μM; 48 hours) significantly increases bad and bax levels, and decreases bcl-2 and bcl-xl levels in contrast, with a significant increase in Bax/Bcl-2 ratio[1]. Cell Viability Assay[1] Cell Line: Normal cells: IOSE144, HL-7702 and LO2, BEAS-2B, GES-1, HEK 293 T, HPDE, FHC, Human cancer cells: PANC-1, Mapaca-1, hepG2, SGC-7901, CBC-SD,SGC-996,PC-3,MKN-45,MGC-803,Hela and HCT116 cells Concentration: 0, 3.9, 7.8, 15.5, 31, 62.5, 125, 250, 500 μM Incubation Time: 48 hours Result: Exhibited the most potent cytotoxicity to cancer cells. Cell Cycle Analysis[1] Cell Line: PANC-1 cells; Miapca-2 cells Concentration: 20 μM Incubation Time: 48 hours Result: Led to accumulated population in the S phase. Western Blot Analysis[1] Cell Line: PANC-1 cells; Miapca-2 cells Concentration: 20 μM Incubation Time: 48 hours Result: Induced the activation of intrinsic apoptosis pathway.
In Vivo Sophoridine (intraperitoneal injection; 20 or 40 mg/kg; 21 days) can inhibit the growth of xenograft pancreatic tumors[1]. Animal Model: BALB/c homozygous (nu/nu) nude mice[1] Dosage: 20 or 40 mg/kg Administration: Intraperitoneal injection; 20 or 40 mg/kg; 21 days Result: Decreased xenograft pancreatic tumors mass.
References

[1]. Xu Z, et al. Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells. J Exp Clin Cancer Res. 2017 Sep 11;36(1):124.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 396.7±31.0 °C at 760 mmHg
Melting Point 109 °C
Molecular Formula C15H24N2O
Molecular Weight 248.364
Flash Point 172.7±17.2 °C
Exact Mass 248.188858
PSA 23.55000
LogP 1.44
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.581

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WG1250000
CHEMICAL NAME :
Sophoridine
CAS REGISTRY NUMBER :
6882-68-4
LAST UPDATED :
199412
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C15-H24-N2-O
MOLECULAR WEIGHT :
248.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
243 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 27,201,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
64300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 8,153,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
46800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YFZADL Yaowu Fenxi Zazhi. Journal of Pharmaceutical Analysis. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1981- Volume(issue)/page/year: 6,96,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
350 mg/kg/35D-I
TOXIC EFFECTS :
Blood - changes in leukocyte (WBC) count
REFERENCE :
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 8,153,1987

 Safety Information

Hazard Codes Xi
Safety Phrases 24/25

 Synonyms

1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, dodecahydro-, (7aR,13aR,13bR,13cS)-
Allomatrine
(5β)-Matridin-15-one
Bio-0637
5-Epidihydrosophocarpine
Dihydro-5-episophocarpine
(7aR,13aR,13bR,13cS)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one
sophoridine
matridin-15-one
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Related Compounds: More...
sophoridine
83148-91-8
(-)-sophoridine N-oxide
1217501-78-4
Chemsrc provides Sophoridine(CAS#:6882-68-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Sophoridine are included as well.>> amp version: Sophoridine

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