2013-58-3

• 常用中文名：氯甲烯土霉素
• 常用英文名：GS-2989
• CAS号：2013-58-3
• 分子式：C₂₂H₂₁ClN₂O₈
• 分子量：476.86
• 相关类别： 原料药 抗生素类药物 四环素类药
• 发布时间：2018-07-11 15:04:38
• 更新时间：2026-07-01 12:06:18
• Meclocycline 是一种四环素衍生物。四环素的主要靶标是细菌核糖体。

名称

• 中文名: 氯甲烯土霉素
• 英文名: meclocycline
• 中文别名: 美氯环素; 甲氯环素; 甲环素; 氯甲稀土霉素
• 英文别名: Meclocycline(usan); (4S,4,5S,5,12aS)-7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-2-naphthacenecboxamide; Chlormethylenecycline; 7-Chloro-6-Methylene-oxytetracycline, GS 2989, NCS; Aids043973; NSC-78502; 2-Naphthacenecboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-, (4S,4,5S,5,12aS); Aids-043973; meclocyline; Meclocycline (1.0mg/ml in DMSO); 2-Naphthacenecboxamide, 7-chloro-4-(dimethylamino)-1,4,4A,5,5A,6,11,12A-octahydro-3,5,10,12,12A-pentahydroxy-6-methylene-1,11-dioxo-, [4S-(4.alpha.,4A.alpha.,5.alpha.,5A.alpha.,12A.alpha.)]- (9ci); (4S)-4β-(Dimethylamino)-1,4,4aβ,5,5aβ,6,11,12a-octahydro-3,5β,10,12,12aβ-pentahydroxy-6-methylene-7-chloro-1,11-dioxo-2-naphthacenecboxamide; Mirabeon Impurity 86 Monomer; MECLOCYLINE; meclocycline //BP; Meclocycline base

物化性质

• 密度: 1.72g/cm3
• 沸点: 716.4ºC at 760mmHg
• 分子式: C₂₂H₂₁ClN₂O₈
• 分子量: 476.86
• 闪点: 387.1ºC
• 精确质量: 476.09900
• PSA: 181.62000
• LogP: 0.91580
• 蒸汽压: 0mmHg at 25°C

生物活性

• 描述: Meclocycline 是一种四环素衍生物。四环素的主要靶标是细菌核糖体。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Fuoco D. Cytotoxicity induced by tetracyclines via protein photooxidation[J]. Advances in Toxicology, et al. Cytotoxicity induced by tetracyclines via protein photooxidation[J]. Advances in Toxicology, 2015, 2015.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QI7830000 CHEMICAL NAME : 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octah ydro- 3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo- CAS REGISTRY NUMBER : 2013-58-3 LAST UPDATED : 198803 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C22-H21-Cl-N2-O8 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 22,1022,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 22,1022,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 425 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GICTAL Giornale Italiano di Chemioterapia. Italian Journal of Chemotherapy. (Edizioni Minerva Medica, Casella Postale 491, I-10126 Turin, Italy) V.1- 1954- Volume(issue)/page/year: 17,276,1970