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| 中文名 | 3-羟基吡嗪-2-酰胺 |
|---|---|
| 英文名 | 3-Hydroxypyrazine-2-carboxamide |
| 中文别名 |
3-羟基吡嗪-2-羧胺
3-羟基吡嗪-2-甲酰胺 3-羟基吡嗪-2-甲酰胺 |
| 英文别名 |
Pyrazine-2-carboxamide, 3-hydroxy-
2-pyrazinecarboxamide, 3-hydroxy- 3-Oxo-3,4-dihydropyrazine-2-carboxamide T6N DNJ BVZ CQ T6MV DNJ CVZ 2-oxo-1H-pyrazine-3-carboxamide 3-hydroxypyrazine-2-carboxamide Pyrazinecarboxamide, 3,4-dihydro-3-oxo- |
| 描述 | T-1105 是一种广谱病毒聚合酶 (polymerase) 抑制剂,T-705 的结构类似物,在转化为核糖核苷三磷酸 (RTP) 代谢物后抑制 RNA 病毒的聚合酶。T-1105 (Favipiravir) 对各种 RNA 病毒表现出抗病毒活性,包括寨卡病毒 (ZIKV),流感病毒,沙粒病毒,布尼亚病毒,西尼罗病毒 (WNV),黄热病病毒 (YFV) 和口蹄疫病毒 (FMDV)。T-1105 可由烟酰胺单核苷酸腺苷酰转移酶形成。 |
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| 相关类别 | |
| 靶点 |
Viral polymerase[1] |
| 参考文献 |
| 密度 | 1.5±0.1 g/cm3 |
|---|---|
| 沸点 | 640.8±55.0 °C at 760 mmHg |
| 熔点 | ca 270℃ |
| 分子式 | C5H5N3O2 |
| 分子量 | 139.112 |
| 闪点 | 341.3±31.5 °C |
| 精确质量 | 139.038177 |
| PSA | 89.10000 |
| LogP | 0.32 |
| 外观性状 | 固体;White to Light yellow powder to crystal |
| 蒸汽压 | 0.0±2.0 mmHg at 25°C |
| 折射率 | 1.634 |
| 储存条件 | 室温，密封 |
|
Material Safety Data Sheet
Section1. Identification of the substance 3-Hydroxypyrazine-2-carboxamide Product Name: Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed.
H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation P261:Avoid breathing dust/fume/gas/mist/vapours/spray Wear protective gloves/protective clothing/eye protection/face protection P280: P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing P304+P340:IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing P405:Store locked up Section3. Composition/information on ingredients. 3-Hydroxypyrazine-2-carboxamide Ingredient name: CAS number:55321-99-8 Section4. First aid measures Immediately wash skin with copious amounts of water for at least 15 minutes while removing Skin contact: contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Ingestion: Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Storage:Store in closed vessels. Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Not specified Appearance: Boiling point:No data Melting point:No data Flash point:No data Density:No data Molecular formula:C5H5N3O2 Molecular weight:139.1 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A |
|
~64%
55321-99-8 |
| 文献：Pierra, Claire; Counor, Clement; Storer, Richard; Gosselin, Gilles Collection of Czechoslovak Chemical Communications, 2011 , vol. 76, # 11 p. 1327 - 1333 |
|
~%
55321-99-8 |
| 文献：Journal of the American Chemical Society, , vol. 69, p. 1034,1035 Journal of the American Chemical Society, , vol. 74, p. 3617,3618,3620 |
|
~%
55321-99-8 |
| 文献：Journal of the American Chemical Society, , vol. 69, p. 1034,1035 |
|
~%
55321-99-8 |
| 文献：Journal of Medicinal Chemistry, , vol. 26, # 2 p. 283 - 286 |
| 上游产品 3 | |
|---|---|
| 下游产品 5 | |
| 海关编码 | 2934999090 |
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| 中文概述 | 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% |
| 申报要素 | 品名, 成分含量, 用途 |
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
