84088-42-6

• 常用中文名：利诺安
• 常用英文名：Roquinimex
• CAS号：84088-42-6
• 分子式：C₁₈H₁₆N₂O₃
• 分子量：308.331
• 相关类别： 信号通路 细胞凋亡 TNF受体
• 发布时间：2018-06-30 10:50:24
• 更新时间：2024-01-09 20:44:14
• Roquinimex (Linomide; PNU212616; ABR212616)是免疫刺激剂,能增强NK细胞活性和巨噬细胞的细胞毒性,抑制血管生成和TNF α的分泌。

名称

• 中文名: 罗喹美克
• 英文名: 4-hydroxy-N,1-dimethyl-2-oxo-N-phenylquinoline-3-carboxamide
• 中文别名: 1,2-二氢-4-羟基-N,N-二甲基-2-氧代-N-苯基-3-喹啉甲酰胺
• 英文别名: Roquinimex; LS-2616; 1,2-Dihydro-4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide; 4-Hydroxy-N,1-dimethyl-2-oxo-N-phenyl-1,2-dihydro-3-quinolinecarboxamide; FCF-89; Linomide; 4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide; N-phenyl-N-methyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline-3-carboxamide; 3-Quinolinecarboxamide, 1,2-dihydro-4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-; N-phenyl-N-methyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-quinoline-3-carboxamide

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 436.2±45.0 °C at 760 mmHg
• 熔点: 204 °C(dec.)
• 分子式: C₁₈H₁₆N₂O₃
• 分子量: 308.331
• 闪点: 217.6±28.7 °C
• 精确质量: 308.116089
• PSA: 62.54000
• LogP: 1.65
• 外观性状: 固体
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.686
• 储存条件: 室温

生物活性

• 描述: Roquinimex (Linomide; PNU212616; ABR212616)是免疫刺激剂,能增强NK细胞活性和巨噬细胞的细胞毒性,抑制血管生成和TNF α的分泌。
• 相关类别:
  信号通路 >> 细胞凋亡 >> TNF受体
  天然产物 >> 生物碱
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Roquinimex, From Wikipedia

  [2]. Liu Q, et al. Roquinimex inhibits dextran sodium sulfate-induced murine colitis. Inflamm Res. 2003 Feb;52(2):64-8.

  [3]. Tian WZ, et al. Linomide (roquinimex) affects the balance between pro- and anti-inflammatory cytokines in vitro in multiple sclerosis. Acta Neurol Scand. 1998 Aug;98(2):94-101.

安全

• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): R22
• 安全声明 (欧洲): S36/37
• 危险品运输编码: UN 2811
• 海关编码: 2933790090

合成路线

57931-81-4 100-61-8 ~78% 84088-42-6

文献：Sjoevall, Sven; Hansen, Lars; Granquist, Bo Organic Process Research and Development, 2004 , vol. 8, # 5 p. 802 - 807

57513-54-9 100-61-8 ~82% 84088-42-6

文献：Joensson, Stig; Andersson, Gunnar; Fex, Tomas; Fristedt, Tomas; Hedlund, Gunnar; Jansson, Karl; Abramo, Lisbeth; Fritzson, Ingela; Pekarski, Olga; Runstroem, Anna; Sandin, Helena; Thuvesson, Ingela; Bjoerk, Anders Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 2075 - 2088

10328-92-4 ~% 84088-42-6

文献：Journal of Medicinal Chemistry, , vol. 47, # 8 p. 2075 - 2088

118-48-9 ~% 84088-42-6

文献：Journal of Medicinal Chemistry, , vol. 47, # 8 p. 2075 - 2088

118-92-3 ~% 84088-42-6

文献：Journal of Medicinal Chemistry, , vol. 47, # 8 p. 2075 - 2088

100-61-8 ~% 84088-42-6

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 4 p. 451 - 452

10328-92-4 84088-88-0 ~49% 84088-42-6

文献：Khan, Saeed R.; Mhaka, Annastasiah; Pili, Roberto; Isaacs, John T. Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 451 - 452

上下游产品

上游产品  7
57931-81-4 100-61-8 10328-92-4 84088-88-0
57513-54-9 118-48-9 118-92-3
下游产品  0

海关

海关编码	2933790090
中文概述	2933790090 其他内酰胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:9.0% 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%