202197-26-0

• 常用中文名：3-氯-4-(3-氟苄氧基)苯胺
• 常用英文名：3-Chloro-4-[(3-fluorobenzyl)oxy]aniline
• CAS号：202197-26-0
• 分子式：C₁₃H₁₁ClFNO
• 分子量：251.684
• 相关类别： 医药中间体 原料药中间体
• 发布时间：2018-12-24 19:51:37
• 更新时间：2026-07-22 18:52:43

名称

• 中文名: 3-氯-4-(3-氟苄氧基)苯胺
• 英文名: 3-chloro-4-[(3-fluorophenyl)methoxy]aniline
• 中文别名: 3-氯-4-(3-氟苯氧基)苯胺; 3-氯-4-(3-氟苄氧基)苯胺 氨基物; 3-氯-4-[(3-氟苄基)氧基]苯胺; 拉帕替尼杂质18; 3-氯-4-((3-氟苄基)氧基)苯胺盐酸盐; 3-氯-4-(3-氟苄氧基)苯胺(拉帕替尼中二); 3-氯-4-(3-氟苄氧胺)苯胺; 拉帕替尼遗传毒性杂质1; 3-氯-4-(3-氟苄氧基)苯胺3-CHLORO-4-(3-FLUOROBENZYLOXY)ANILINE; 4-(3-氟苯甲氧基)-3-氯苯胺; 3-氯-4-(3-氟苯基氧基)苯胺; 3-氯-4-(3-氟苯甲氧基)苯胺; 3-氯-4-(3-氟本甲氧基)苯胺; 3-氯-4-(3-氟苄氧基)苯胺,拉帕替尼中间体; 3-氯-4-(3-氟苄氧基)苯胺(拉帕替尼杂质); 拉帕中二; 拉帕氨基物
• 英文别名: 4-(3-Fluorobenzyloxy)-3-chlorobenzenamine; 3-Chloro-4-(3-fluorobenzyloxy)-anilin; 3-Chloro-4-(3-fluorobenzyloxy)aniline; BenzenaMine, 3-chloro-4-[(3-fluorophenyl)Methoxy]; 4-(3-fluorobenzyloxy)-3-chlorobenzenamine; 3-Chloro-4-(3-fluorobenzyloxy)-aniline; 3-chloro-4-(3-fluoro-benzyloxy)-phenylamine; oxy)aniL; 4-(3-Fluorobenzyloxy)-3-chlorobenzenamine hydrochloride; Lapatinib Impurity 18-d4; 3-Chloro-4-((3-fluorobenzyl)oxy)aniline (Lapatinib Impurity); oro-4-(3-fL; ZR CG DO1R CF; Lapatinib impurity 4 3-Chloro-4-(3-fluorobenzyloxy)aniline; 3-Chloro-4-(3-Flurobenzyloxy) PhenylaMine (LTB-A); 3-Chloro-4-[(3-fluorophenyl)methoxy]benzenamine; Compound PDK0113; 3-Chloro-4-((3-fluorobenzyl); 3-Chloro-4-(3-fluorobenzyloxy)aniline ISO 9001：2015 REACH; 3-chloro-4-((3-fluorobenzyl)oxy)aniline; Lapatinib genotoxic impurity 1; 3-Chloro-4-(3-fluorobenzyloxy)aniline 3-Chloro-4-(3-fluorobenzyloxy)phenylamine; 4 - (- chloro - fluorobenzene Methoxy) aniline; 3-Chloro-4-(3-fluorobenzyloxy)aniline>; LAPATINIB IMP A; 3-chloro-4-{[(3-fluorophenyl)methyl]oxy}aniline; 3-Chloro-4-[(3-fluorophenyl)Methoxy]benzenaMine; 4-(3-Fluorobenzyloxy)- 3-chloroaniline; Lapatinib impurity A; 3-chloro-4-[(3-fluorophenyl)Methoxy]aniline; 3-Chloro-4-(3-fluorobenzyloxy)phenylamine

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 387.9±32.0 °C at 760 mmHg
• 熔点: 78.0 to 82.0 °C
• 分子式: C₁₃H₁₁ClFNO
• 分子量: 251.684
• 闪点: 188.4±25.1 °C
• 精确质量: 251.051315
• PSA: 35.25000
• LogP: 3.28
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.607
• 储存条件: 室温，密封

安全

• 危害码 (欧洲): Xi
• 危险品运输编码: 3077
• 包装等级: III
• 海关编码: 2922299090

合成路线

443882-99-3 ~99% 202197-26-0

文献：Lackey, Karen Elizabeth; Spector, Neil; Wood lll, Edgar Raymond; Xia, Wenle Patent: US2004/53946 A1, 2004 ;

878018-19-0 ~92% 202197-26-0

文献：BAYER HEALTHCARE AG Patent: US2010/298297 A1, 2010 ; Location in patent: Page/Page column 14 ;

619-08-9 ~% 202197-26-0

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 17 p. 4686 - 4691

456-41-7 ~% 202197-26-0

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 17 p. 4686 - 4691

350-30-1 ~% 202197-26-0

文献：WO2011/2523 A1, ; WO 2011/002523 A1

456-47-3 ~% 202197-26-0

文献：WO2011/2523 A1, ; WO 2011/002523 A1

上下游产品

上游产品  6
443882-99-3 878018-19-0 619-08-9 456-41-7
350-30-1 456-47-3
下游产品  8
388082-78-8 897383-62-9 1050500-29-2 231278-84-5
231278-20-9 231277-92-2 848133-17-5 388082-81-3

海关

海关编码	2922299090
中文概述	2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
Summary	2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%