112875-61-3

• 常用中文名：1,3-双-O-(叔丁基二甲基甲硅烷基)骨化三烯
• 常用英文名：Impurity F of Calcipotriol
• CAS号：112875-61-3
• 分子式：C₃₉H₆₈O₃Si₂
• 分子量：641.12600
• 相关类别： 信号通路 维生素 D 相关 VD/VDR
• 发布时间：2017-09-30 02:37:15
• 更新时间：2026-07-20 21:02:42
• Impurity F of Calcipotriol是钙泊三醇的杂质,钙泊三醇是1,25-Dihydroxyvitamin D3类似物。

名称

• 中文名: 卡泊三醇的杂质F.
• 英文名: (E,1S,4R)-4-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-1-cyclopropylpent-2-en-1-ol
• 中文别名: HT007-27钙泊三醇杂质F; 卡泊三醇N-1; 钙泊三醇杂质F; 卡泊三醇杂质F; 卡泊三醇杂质F:双叔丁基二甲基甲硅烷基 - 顺式卡泊三醇; 卡泊三醇杂质6(卡泊三醇杂质F); 钙泊三醇双TBS; 1,3-双TBS-钙泊三醇; 1,3-二-O-(叔-丁基二甲基硅烷基)卡泊三醇
• 英文别名: 1,3-Bis-O-(tert-butyldimethylsilyl)calcipotriene; Bis-TBDMS-Calcipotriol; Cpotriol Impurity F; (1S,3R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'(S)-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-9,10-secopregna-5(Z),7(E),10-triene; Calcipotriene N-1; Calcipotriol Impurity F; UNII-4SP93VP62P; Cyclopropanemethanol, α-[(1E,3R)-3-[(1R,3aS,4E,7-4-[(2Z)-2-[(3S,5R)-3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-buten-1-yl]-, (αS); (1S,4R,E)-4-((1R,3aS,7,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldiMethylsilyl)oxy)-2-Methylenecyclohexylidene)ethylidene)-7a-Methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol; 1(S),3(R)-bis(tert-butyl-dimethylsilyloxy)-20(R)-(3'-cyclopropyl-3(S)'-hydroxyprop-1'(E)-enyl)-9,10-secopregna-5(Z),7(E),10(19)-triene; Calcipotriol double TBS; 1,3-bi-TBS-Calcipotriol; Calcipotriol Impurity 6(Calcipotriol Impurity F); (1S,3R)-bis(tert-butyldimethylsilyloxy)-20(R)-(3'(S)-cyclopropyl-3'-hydroxyprop-1'(E)-enyl)-9,10-secopregna-5(Z),7(E),10(19)-triene; Calcipotriol Impurity F: Bis-tert-butyldimethylsilyl-cis-calcipotriol; Calcipotriol Impurity F/1,3-Bis-O-(tert-butyldimethylsilyl)calcipotriene; IMpurity F of Calcipotriol; Gentamicin Sulfate Impurity Ⅲ:(Gentamicin A)4-O-(2-Amino-2-deoxy-α-D-glucopyranosyl)-6-O-[3-(methylamino)-3-deoxy-α-D-xylopyranosyl]-2-deoxy-D-strtamine; Impurity F

物化性质

• 分子式: C₃₉H₆₈O₃Si₂
• 分子量: 641.12600
• 精确质量: 640.47100
• PSA: 38.69000
• LogP: 11.14960
• 储存条件: 2-8℃

生物活性

• 描述: Impurity F of Calcipotriol是钙泊三醇的杂质,钙泊三醇是1,25-Dihydroxyvitamin D3类似物。
• 相关类别:
  信号通路 >> 维生素 D 相关 >> VD/VDR
  研究领域 >> 癌症
• 参考文献:

  [1]. Binderup (1993) Comparison of calcipotriol with selected metabolites and analogues of vitamin D3: effects on cell growth regulation in vitro and calcium metabolism in vivo. Pharmacol.Toxicol. 72 240.

  [2]. Knutson et al (1997) Pharmacokinetics and systemic effect on calcium homeostasis of 1a,24-dihydroxyvitamin D2 in rats. Biochem.Pharmacol. 53 829.

  [3]. Wietrzyk et al (2007) Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anticancer Drugs 18 447.111

  [4]. Lise Binderup,, Erik Bramm. Effects of a novel vitamin D analogue MC 903 on cell proliferation and differentiation in vitro and on calcium metabolism in vivo. Biochemical Pharmacology. Volume 37, Issue 5, 1 March 1988, Pages 889-895

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