36148-89-7

• 常用中文名：两性霉素B甲酯
• 常用英文名：AmphotericinB
• CAS号：36148-89-7
• 分子式：C₄₈H₇₅NO₁₇
• 分子量：938.106
• 相关类别： 信号通路 抗感染 真菌
• 发布时间：2018-04-18 08:00:00
• 更新时间：2026-07-04 10:32:18
• Amphotericin B methyl ester 是多烯类抗生素 Amphotericin B (A634250) 的甲酯衍生物。Amphotericin B methyl ester 是胆固醇结合物,具有显著的抗真菌活性。Amphotericin B methyl ester 干扰 HIV-1 颗粒的产生,抑制 HIV-1 的复制。

名称

• 中文名: 两性霉素B甲酯
• 英文名: amphotericin B methyl ester
• 中文别名: 两性霉素B杂质 B; 两性霉素B杂质B:1R-氧-甲基-两性霉素B; 氘3-两性霉素B甲酯; (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-(((2R,3S,4S,5S,6R)-4-氨基-3,5-二羟基-6-甲基四氢四氢-2H-吡喃-2-基)氧基)-1,3,5,6,6,9,11,17,37-八羟基-15,16,18-三甲基-13-氧代-14,39-二氧杂双环[33.3.1]三十九烷-19,21,23,25,27,29,31-七烯-36-羧酸甲酯; 两性霉素甲酯-D3*杂质1; 两性霉素B-13C6甲酯; 两性霉素杂质1(两性霉素B甲酯); 两性霉素B甲基酯
• 英文别名: Methyl (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-(((2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-htaene-36-cboxylate; Amphotericin B, methyl ester; Amphotericin B Methyl Ester; 35-Deoxy Amphotericin B Methyl; Amphotericin B monomethyl ester; methylamphotericin b; methyl (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylate; Aids000095; Amphotericin B Impurit B:Amphotericin B Methyl Ester ( Amphotericin B Monomethyl Ester); Methyl (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14, 39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylate; D3-Amphotericin B methyl ester; Methylamphotericin B; Amphotericin B Impurity 4 (Amphotericin B Methyl Ester); Amphotericin B Impurity B; Amb; Ame; Aids-000095; Amphotericin B Impurity 1(Amphotericin B Methyl Ester)

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 1102.6±65.0 °C at 760 mmHg
• 分子式: C₄₈H₇₅NO₁₇
• 分子量: 938.106
• 闪点: 620.6±34.3 °C
• 精确质量: 937.503479
• PSA: 308.61000
• LogP: 1.63
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.602

生物活性

• 描述: Amphotericin B methyl ester 是多烯类抗生素 Amphotericin B (A634250) 的甲酯衍生物。Amphotericin B methyl ester 是胆固醇结合物,具有显著的抗真菌活性。Amphotericin B methyl ester 干扰 HIV-1 颗粒的产生,抑制 HIV-1 的复制。
• 相关类别:
  信号通路 >> 抗感染 >> HIV
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 真菌
• 体外研究: 两性霉素B甲酯抑制HIV-1颗粒的产生,对Gag与质膜的结合、Gag与脂筏的结合或Gag多聚化没有显著影响[1]。
• 参考文献:

  [1]. Waheed AA, et al. Inhibition of human immunodeficiency virus type 1 assembly and release by the cholesterol-binding compound amphotericin B methyl ester: evidence for Vpu dependence. J Virol. 2008 Oct;82(19):9776-81.

  [2]. Keim GR, et al. Comparative toxicological studies of amphotericin B methyl ester and amphotericin B in mice, rats, and dogs. ntimicrob Agents Chemother. 1976 Oct;10(4):687-90.

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