75438-57-2

• 常用中文名：莫索尼定
• 常用英文名：Moxonidine
• CAS号：75438-57-2
• 分子式：C₉H₁₂ClN₅O
• 分子量：241.678
• 相关类别： 原料药 循环系统用药 抗高血压病药
• 发布时间：2018-09-28 17:43:23
• 更新时间：2026-07-02 21:40:11
• Moxonidine(BDF5895)是咪唑啉1型受体(I1-R)选择性激动剂,为降压剂。

名称

• 中文名: 莫索尼啶
• 英文名: 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methylpyrimidin-5-amine
• 中文别名: 莫索尼定(标准品); 4-氯-N-(4,5-二氢-1H-咪唑-2-基)-6-甲氧基-2-甲基嘧啶-5-胺; 2-(6-氯-4-甲氧; 莫索尼定 标准品; 4-氯-N-咪唑啉-2-基亚甲基-6-甲氧基-2-甲基嘧啶-5-胺; 莫索尼定,10 MM DMSO 溶液; 莫索尼定杂质; 莫索尼定-D3; 莫索尼啶杂质; 4-氯-N-(4,5-二氢-1H-咪唑基-2-基)-6-甲氧基-5-氨基-2-甲基嘧啶; 4-氯-N-(4,5-二氢-1H-咪唑基-2-基)-6-甲氧基-2-甲基嘧啶-5-胺; 莫索尼啶相关杂质; 莫索尼定,不带盐酸; 4-氯-N-(4,5-二氢-1H-咪唑-2-基)-6-甲氧基-2-甲基-5-嘧啶胺; (4-氯-6-甲氧基-2-甲基-嘧啶-5-基)-(4,5-二氢-1H-咪唑基-2-基)胺; 4-氯-N-(4,5-二氢-1H-咪唑基-2-基)-6-甲氧基-2-甲基-嘧啶-5-胺; 莫索尼啶2
• 英文别名: 4-Chloro-N-(4，5-dihydro-1H-imidaml-2-y1)-6-methoxy-2-methyl-5-pyrimidinamine; LoMox; Moxonidine CRS; Moxonidin; T6N CNJ B1 DO1 FG EM- BT5M CN BUTJ; Nucynt; 4-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamin; BDF-5895 HCL; Moxonidine-d3; Moxonidine Impurity 2; bdf5895; be5895; [3H]-Moxonidine; Physioterls; 4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine; Moxonidine //BP; 2-(6-Chloro-4-Methoxy-2-MethylpyriMidin-5-ylaMino)-2-iMidazoline; 4-chloro-N-imidazolidin-2-ylidene-6-methoxy-2-methylpyrimidin-5-amine; Normoxocin; 4-Chloro-5-(2-imidazolin-2-ylamino)-6-methoxy-2-methylpyrimidine; MOXONIDINE HCL; Moxonidine 13CD3Q: What is Moxonidine 13CD3 Q: What is the CAS Number of Moxonidine 13CD3 Q: What is the storage condition of Moxonidine 13CD3; 4-chloro-5-[(4,5-dihydro-1H-imidazol-2-yl)-amino]-6-methoxy-2-methylpyrimidine; 4-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-6-METHOXY-2-METHYL-5-PYRIMIDINAMINE HYDROCHLORIDE; Moxonidine (BDF5895); MFCD06795643; 4-chloro-5-(imidazoline-2-ylamino)-6-methoxy-2-methylpyrimidine; (4-chloro-6-methoxy-2-methyl-pyrimidin-5-yl)-(4,5-dihydro-1H-imidazol-2-yl)amine; 5-Pyrimidinamine, 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl; 4-Chloro-N-(imidazolidin-2-ylidene)-6-methoxy-2-methylpyrimidin-5-amine; BE 5895; Moxonidine >; 4-chloro-N-(4,5-dihydro-1H9imidazol-yl)-6-methoxy-2-methyl-5-pyrimidinamine; Physiotens; NorMoxocin; 4-Chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine hydrochloride; [14C]-Moxonidine; Moxonidine 1.0 mg/ml in Methanol; 4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methylpyrimidin-5-amine; MOXONIDINE/4-CHLORO-N-(4,5-DIHYDRO-1H-2-IMIDAZOLYL)-6-METHOXY-2-METHYL-5-PYRAMINE; MoxonidineQ: What is Moxonidine Q: What is the CAS Number of Moxonidine Q: What is the storage condition of Moxonidine Q: What e the applications of Moxonidine; 4-CHLORO-6-METHOXY-2-METHYL-5-(2-IMIDAZOLIN-2-YL)AMINOPYRIMIDINE HCL; Norcynt; Lomox; MOXONIDINE; Moxonidine, 10 mM in DMSO; Cynt; Moxonidinum [Latin]; T6N CNJ B1 DO1 FG ENU- BT5MYMTJ

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 364.7±52.0 °C at 760 mmHg
• 熔点: 40-43 °C(lit.)
• 分子式: C₉H₁₂ClN₅O
• 分子量: 241.678
• 闪点: 174.3±30.7 °C
• 精确质量: 241.073044
• PSA: 71.43000
• LogP: 0.84
• 外观性状: 晶体
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.681
• 储存条件: Desiccate at +4°C
• 计算化学:

  1.疏水参数计算参考值（XlogP）:0.6

  2.氢键供体数量:2

  3.氢键受体数量:4

  4.可旋转化学键数量:3

  5.互变异构体数量:2

  6.拓扑分子极性表面积71.4

  7.重原子数量:16

  8.表面电荷:0

  9.复杂度:275

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1.性状：结晶

  2.熔点（ºC）：217-219℃(分解)。

生物活性

• 描述: Moxonidine(BDF5895)是咪唑啉1型受体(I1-R)选择性激动剂,为降压剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 咪唑啉受体
  信号通路 >> 神经信号通路 >> 咪唑啉受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Schafer, U., et al., Presynaptic effects of moxonidine in isolated buffer perfused rat hearts: role of imidazoline-1 receptors and alpha2-adrenoceptors. J Pharmacol Exp Ther, 2002. 303(3): p. 1163-70.

  [2]. Chan, C.K., et al., Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine. Neuroscience, 2005. 132(4): p. 991-1007.

安全

• 危害码 (欧洲): Xn
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: UV6260290
• 危险类别: 6.1

合成路线

上下游产品

上游产品  5
75438-54-9 67-56-1 287099-40-5 124-41-4
438000-58-9
下游产品  0

制备

方法1：5-氨基-4，6-二氯-2-甲基嘧啶和1-乙酰基-2-咪唑啉-2-酮反应，生成的产物和甲醇钠作用得莫索尼定。

方法2：5-氨基-4-氯-6-甲氧基-2-甲基嘧啶和硫氰酸铵及苯甲酰氯反应，得(I)。去苯甲酰基得(Ⅱ)，甲基化得(Ⅲ)，再和乙二胺作用得莫索尼定。