50935-04-1

• 常用中文名：洋红霉素
• 常用英文名：Carubicin
• CAS号：50935-04-1
• 分子式：C₂₆H₂₇NO₁₀
• 分子量：513.493
• 发布时间：2018-06-02 08:00:00
• 更新时间：2024-01-02 14:50:39
• 胡萝卜素(Carminomycin)是一种微生物衍生的化合物。胡萝卜素是VHL缺陷型(VHL)的有效抑制剂−/−) CCRCC细胞增殖。胡萝卜素也通过一种独立于p53或缺氧诱导因子HIF2的机制诱导细胞凋亡。胡萝卜素具有研究癌症疾病的潜力[1][2]。

名称

• 中文名: 卡米诺霉素
• 英文名: 5,12-Naphthacenedione, 8-acetyl-10-[[3-amino-2,3,6-trideoxy-.α.-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-, (8S-cis)
• 中文别名: 洋红霉素
• 英文别名: (1S,3S)-3-Acetyl-3,5,10,12-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside; Carminomycin; (1S,3S)-3-Acetyl-3,5,10,12-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside; Carminomycin I; Antibiotic R-588A; Carminomicin I; (1S,3S)-3-Acetyl-1,2,3,4,6,11-hexahydro-3,5,10,12-tetrahydroxy-6,11-dioxo-1-naphthacenyl 3-Amino-2,3,6-trideoxy-a-L-lyxo-hexopyranoside; Karminomitsin; 5,12-Naphthacenedione, 8-acetyl-10-((3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-, (8S-cis)-; 4-O-Demethyldaunorubicin; 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-, (8S,10S)-; Karminomycin; (8S-cis)-Acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-5,12-naphthacenedione; Carubicin

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 750.6±60.0 °C at 760 mmHg
• 分子式: C₂₆H₂₇NO₁₀
• 分子量: 513.493
• 闪点: 407.7±32.9 °C
• 精确质量: 513.163513
• PSA: 196.84000
• LogP: 3.54
• 蒸汽压: 0.0±2.6 mmHg at 25°C
• 折射率: 1.727
• 储存条件: 库房低温通风干燥,与食品原料分开存放

生物活性

• 描述: 胡萝卜素(Carminomycin)是一种微生物衍生的化合物。胡萝卜素是VHL缺陷型(VHL)的有效抑制剂−/−) CCRCC细胞增殖。胡萝卜素也通过一种独立于p53或缺氧诱导因子HIF2的机制诱导细胞凋亡。胡萝卜素具有研究癌症疾病的潜力[1][2]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  研究领域 >> 感染
• 参考文献:

  [1]. [1]Woldemichael GM, et al. Carminomycin I is an apoptosis inducer that targets the Golgi complex in clear cell renal carcinoma cells. Cancer Res. 2011 Jan 1;71(1):134-42.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QI9293250 CHEMICAL NAME : 5,12-Naphthacenedione, 8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hex opyranosyl)oxy)- 7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-, (8S-cis)- CAS REGISTRY NUMBER : 50935-04-1 LAST UPDATED : 199406 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C26-H27-N-O10 MOLECULAR WEIGHT : 513.54 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 7250 ug/kg TOXIC EFFECTS : Behavioral - tremor Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1100 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3800 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - tremor Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3400 ug/kg TOXIC EFFECTS : Behavioral - tremor Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain MUTATION DATA TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - mouse Leukocyte DOSE/DURATION : 490 nmol/L REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 34,1596,1981

合成路线

68594-06-9 ~% 50935-04-1

文献：Zabudkin, Alexander F.; Matvienko, Victor; Matveev, Alexey; Itkin, Aleksandr M. Patent: US2007/135624 A1, 2007 ; Location in patent: Page/Page column 2 ;

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