3563-01-7

• 常用中文名：异戊基丙二酸二乙酯
• 常用英文名：Diethylaminoethyl
• CAS号：3563-01-7
• 分子式：C₂₁H₂₇NO₂
• 分子量：325.44500
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 由mAChR
• 发布时间：2018-05-08 08:00:00
• 更新时间：2024-01-05 22:04:45
• Aprophen (Aprofene) 是一种抗毒蕈碱抑制剂。Aprophen 可用于中枢神经系统的研究。

名称

• 中文名: 异戊基丙二酸二乙酯
• 英文名: 2-(Diethylamino)ethyl 2,2-diphenylpropanoate
• 英文别名: Aprofenum [INN-Latin]; Aprophenum; 2,2-Diphenyl-propionsaeure-(2-diaethylamino-aethylester); Propionic acid,2,2-diphenyl-,2-(diethylamino)ethyl ester; Aprofeno [INN-Spanish]; Diphenyl-methyl-essigsaeure-(2-aethyl-diaethylamin)-ester; 2-Diethylaminoethyl 2,2-diphenylpropionate; Aprofene; Aprofen; 2,2-diphenyl-propionic acid-(2-diethylamino-ethyl ester); Aprophen

物化性质

• 密度: 1.041g/cm3
• 沸点: 434.8ºC at 760mmHg
• 分子式: C₂₁H₂₇NO₂
• 分子量: 325.44500
• 闪点: 132.5ºC
• 精确质量: 325.20400
• PSA: 29.54000
• LogP: 3.87760
• 折射率: 1.537

生物活性

• 描述: Aprophen (Aprofene) 是一种抗毒蕈碱抑制剂。Aprophen 可用于中枢神经系统的研究。
• 相关类别:
  信号通路 >> 神经信号通路 >> mAChR
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. A comparison of the antimuscarinic properties of aprophen with those of some other anticholinergic drugs. Issue: MRL-R-794. Pages: 10 pp. Report 1980.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UF2032500 CHEMICAL NAME : Propionic acid, 2,2-diphenyl-, 2-(diethylamino)ethyl ester CAS REGISTRY NUMBER : 3563-01-7 BEILSTEIN REFERENCE NO. : 2509326 LAST UPDATED : 199707 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C21-H27-N-O2 MOLECULAR WEIGHT : 325.49 WISWESSER LINE NOTATION : 2N2&2OVX1&R&R HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 125 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 4,7,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 370 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 31,53,1968

安全

• 海关编码: 2922199090

合成路线

86-29-3 ~% 3563-01-7

文献：Lu, Mattias C.; Wung, Walley E.; Shih, Lisa B.; Callejas, Soledad; Gearien, James E.; Thompson, Emmanuel B. Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 273 - 278

22875-82-7 ~% 3563-01-7

文献：Lu, Mattias C.; Wung, Walley E.; Shih, Lisa B.; Callejas, Soledad; Gearien, James E.; Thompson, Emmanuel B. Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 273 - 278

5558-67-8 ~% 3563-01-7

文献：Lu, Mattias C.; Wung, Walley E.; Shih, Lisa B.; Callejas, Soledad; Gearien, James E.; Thompson, Emmanuel B. Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 273 - 278

5558-66-7 ~% 3563-01-7

文献：Lu, Mattias C.; Wung, Walley E.; Shih, Lisa B.; Callejas, Soledad; Gearien, James E.; Thompson, Emmanuel B. Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 273 - 278

40997-78-2 100-37-8 ~% 3563-01-7

文献：Lu, Mattias C.; Wung, Walley E.; Shih, Lisa B.; Callejas, Soledad; Gearien, James E.; Thompson, Emmanuel B. Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 273 - 278

5558-66-7 100-35-6 ~% 3563-01-7

文献：Zaugg; Horrom Journal of the American Chemical Society, 1950 , vol. 72, p. 3004,3005

上下游产品

上游产品  5
86-29-3 5558-67-8 5558-66-7 100-37-8
100-35-6
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海关

海关编码	2922199090
中文概述	2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%