150-90-3

• 常用中文名：丁二酸钠
• 常用英文名：Disodium succinate
• CAS号：150-90-3
• 分子式：C₄H₄Na₂O₄
• 分子量：162.052
• 相关类别： 有机原料 有机金属盐
• 发布时间：2018-06-27 17:16:44
• 更新时间：2024-01-01 23:17:05
• Disodium succinate 是 Succinic acid 的盐形式。Succinic acid 是三羧酸循环的中间产物,也是无氧代谢的发酵产物之一。

名称

• 中文名: 丁二酸二钠
• 英文名: sodium succinate (anhydrous)
• 中文别名: 丁二酸钠; 琥珀酸二钠盐
• 英文别名: sodium succinate; Sodium succinate dibasic; Succinic acid disodium salt; 3-Pyridinecarboxylicacid,2-[1-[[[(3,5-difluorophenyl)amino]carbonyl]hydrazono]ethyl]-(9CI); sodium 21-succinate; Sodium succinate dibasic,Succinic acid disodium salt; succinic acid sodium salt; EINECS 205-778-7; 3-Pyridinecarboxylicacid,2-[1-[2-[[(3,5-difluorophenyl)amino]carbonyl]hydrazinylidene]ethyl]; Diflufenzopyr; Succinic acid, disodium salt; UNII-V8ZGC8ISR3; Disodium succinate; sodium 2-{1-[4-(3,5-difluorophenyl)semicarbazono]ethyl}nicotinate; SAN 835H; succinic acid disodim salt; Butanedioic acid, sodium salt (1:2); sodium salt of 2-acetylnicotinic acid 4-(3,5-difluorophenyl)semicarbazone; Succinic acid,disodium salt; MFCD00002790; BAS654H; sodium acetate-acetic acid; sodium succinate (anhydrous); Butanedioic acid disodium salt; diflufenzopyr-Na

物化性质

• 分子式: C₄H₄Na₂O₄
• 分子量: 162.052
• 闪点: 110.9ºC
• 精确质量: 161.990494
• PSA: 80.26000
• 外观性状: 白色结晶粉末
• 蒸汽压: 0.0165mmHg at 25°C
• 储存条件:

  应密封保存。

• 稳定性:

  无臭，无酸味。有特殊贝类鲜味。在空气中稳定。六水物至120℃时失去结晶水而为无水物。

• 水溶解性: 300 g/L (25 ºC)
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:0

  3.氢键受体数量:4

  4.可旋转化学键数量:1

  5.互变异构体数量:无

  6.拓扑分子极性表面积80.3

  7.重原子数量:10

  8.表面电荷:0

  9.复杂度:81.6

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:3

• 更多:

  1. 性状：结晶品为白色结晶颗粒；无水物为结晶性粉末。

  2. 溶解性：易溶于水，不溶于乙醇。

生物活性

• 描述: Disodium succinate 是 Succinic acid 的盐形式。Succinic acid 是三羧酸循环的中间产物,也是无氧代谢的发酵产物之一。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Zhang YJ, et al. Optimization of succinic acid fermentation with Actinobacillus succinogenes by response surface methodology (RSM). J Zhejiang Univ Sci B. 2012 Feb;13(2):103-10.

MSDS

Name: Succinic acid disodiumsalt anhydrous 99% Material Safety Data Sheet Synonym: Disodium succinate, anhydrou CAS: 150-90-3 Section 1 - Chemical Product MSDS Name:Succinic acid disodiumsalt anhydrous 99% Material Safety Data Sheet Synonym:Disodium succinate, anhydrou Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 150-90-3 Succinic acid, disodium salt, anhydrou 99.0 205-778-7 Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Hygroscopic (absorbs moisture from the air). Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion: Low hazard for usual industrial handling. Inhalation: May cause respiratory tract irritation. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear. Notes to Physician: Antidote: None reported. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 150-90-3: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Powder Color: white Odor: odorless pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: Not available. Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: N/A Explosion Limits, upper: N/A Decomposition Temperature: Solubility in water: 300 G/L (25C) Specific Gravity/Density: Molecular Formula: C4H4O4Na2 Molecular Weight: 162.05 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Dust generation, exposure to moist air or water. Incompatibilities with Other Materials: Strong oxidizing agents, strong acids. Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, acrid smoke and fumes. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 150-90-3: WM7751000 LD50/LC50: Not available. Carcinogenicity: Succinic acid, disodium salt, anhydrous - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 150-90-3: 0 Canada CAS# 150-90-3 is listed on Canada's DSL List. CAS# 150-90-3 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 150-90-3 is listed on the TSCA inventory. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 1、急性毒性：小鼠静脉LD50：4500 mg/kg。 2、青蛙皮下注射MID：1.8～2.0g/kg。 生态学数据: 其它有害作用：该物质对环境可能有危害，对水体应给予特别注意。 CHEMICAL IDENTIFICATION RTECS NUMBER : WM7751000 CHEMICAL NAME : Succinic acid, disodium salt CAS REGISTRY NUMBER : 150-90-3 LAST UPDATED : 199701 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C4-H4-O4.2Na MOLECULAR WEIGHT : 162.06 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,1368,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80528 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80528 No. of Facilities: 159 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 2247 (estimated) No. of Female Employees: 1382 (estimated)

安全

• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): S26-S36-S24/25
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 1
• RTECS号: WM7751000
• 海关编码: 2917190090

合成路线

556-32-1 ~% 150-90-3

文献：WO2011/98598 A1, ; Page/Page column 15-17 ;

140-99-8 ~% 150-90-3

文献：WO2011/98598 A1, ; Page/Page column 15-17 ;

3105-55-3 ~% 150-90-3 17013-01-3

文献：Bulletin of the Chemical Society of Japan, , vol. 65, # 4 p. 1168 - 1169

69361-29-1 ~% 150-90-3

文献：Collection of Czechoslovak Chemical Communications, , vol. 45, # 11 p. 2873 - 2882

25289-18-3 ~% 150-90-3

文献：Zeitschrift fuer Elektrochemie und Angewandte Physikalische Chemie, , vol. 30, p. 343

50888-28-3 ~% 150-90-3

文献：Collection of Czechoslovak Chemical Communications, , vol. 45, # 11 p. 2873 - 2882

上下游产品

上游产品  5
556-32-1 140-99-8 3105-55-3 69361-29-1
25289-18-3
下游产品  10
503-66-2 480-97-7 20862-58-2 23783-79-1
66-71-7 97-67-6 110-17-8 93-97-0
65-85-0 83-25-0

制备

将琥珀酸与氢氧化钠中和，经120℃干燥、粉碎即可。

海关

海关编码	2917190090
中文概述	2917190090 其他无环多元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分
Summary	2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%