207347-42-0

• 常用中文名：3'-DA(BZ)亚磷酰胺单体
• 常用英文名：N6-Bz-5'-O-DMTr-3'-deoxyadenosine-2'-O-CED-phosphoramidite
• CAS号：207347-42-0
• 分子式：C₄₇H₅₂N₇O₇P
• 分子量：857.93
• 相关类别： 信号通路 细胞周期/DNA损伤 核苷抗代谢药/类似物
• 发布时间：2017-12-31 15:12:56
• 更新时间：2026-07-15 16:11:26
• N6-Bz-5'-O-DMTr-3'-脱氧腺苷-2'-O-CED-磷酰胺是腺苷类似物。腺苷类似物主要起到平滑肌血管扩张剂的作用,也被证明可以抑制癌症的进展。其受欢迎的产品有磷酸腺苷、阿卡地辛(HY-13417)、氯法拉滨(HY-A0005)、磷酸氟达拉滨(HY-B0028)和维达拉宾(HY-B0277)[1]。

名称

• 中文名: 3'-DA(BZ)亚磷酰胺单体
• 英文名: 3'-da cep
• 中文别名: N6-苯甲酰基-5'-O-[二(4-甲氧基苯基)苯基甲基]-3'-脱氧腺苷-2'-[2-氰基乙基二异丙基氨基亚磷酸酯]; N6-BZ-5'-O-DMTR-3'-脱氧腺苷-2'-O-CED-磷脒; (2R,3R,5S)-2-(6-苄基-9H-嘌呤-9-基)-5-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺; N6-苯甲酰基-5'-O-DMT-3'-脱氧腺苷2'-CE 亚磷酰胺
• 英文别名: 3'-Deoxy-A(Bz)-2'-phosphoramidite; N6-Benzoyl-5'-O-DMT-3'-deoxyadenosine 2'-CE phosphoraMidite; N6-Benzoyl-3'-deoxy-5'-O-DMT-adenosine 2'-CE phosphoramidite; (2R,3R,5S)-2-(6-Benzamido-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl (2-cyanoethyl) diiSopropylphosphoramidite; N6-Benzoyl-5'-O-DMT-3'-deoxyadenosine 2'-CE phosphoramidite; 3'-dAC; N6-Bz-5’-O-DMTr-3’-deoxyadenosine-2’-O-CED-phosphoramidite,3’-Deoxy-A(Bz)-2’-phosphoramidite; N6-benzoyl-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)adenosine 2'-(2-cyanoethyl diisopropylphosphoramidite); Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-deoxy-, 2'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N6-Bz-5’-O-DMTr-3’-dA-2’-O-CED-phosphoramidite; 3'-dA; 3'-da-CE Phosphoramidite; N6-Bz-5''-O-DMTr-3''-deoxyadenosine-2''-O-CED-phosphoramidite; 3'-DA C; N6-BENZOYL-5'-O-(4,4'-DIMETHOXYTRITYL)-3'-DEOXYADENOSINE, 2'-[(2-CYANOETHYL)-(N,N-DIISOPROPYL)]PHOSPHORAMIDITE

物化性质

• 分子式: C₄₇H₅₂N₇O₇P
• 分子量: 857.93
• 精确质量: 857.36700
• PSA: 168.70000
• LogP: 9.12618

生物活性

• 描述: N6-Bz-5'-O-DMTr-3'-脱氧腺苷-2'-O-CED-磷酰胺是腺苷类似物。腺苷类似物主要起到平滑肌血管扩张剂的作用,也被证明可以抑制癌症的进展。其受欢迎的产品有磷酸腺苷、阿卡地辛(HY-13417)、氯法拉滨(HY-A0005)、磷酸氟达拉滨(HY-B0028)和维达拉宾(HY-B0277)[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
• 参考文献:

  [1]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500.

合成路线

102691-36-1 84138-86-3 ~91% 207347-42-0

文献：Charubala, Ramamurthy; Pfleidere, Wolfgang; Suhadolnik, Robert J.; Iacono, Kathryn T.; Muto, Nicholas F.; Homan, Joseph W.; Martinand-Mari, Camille; Horvath, Susan E.; Henderson, Earl E.; Steele, Amber; Rogers, Thomas J. Helvetica Chimica Acta, 2002 , vol. 85, # 8 p. 2284 - 2299

124482-92-4 84138-86-3 ~67% 207347-42-0

文献：Arslan, Tuncer; Abraham, Anil T.; Hecht, Sidney M. Nucleosides and Nucleotides, 1998 , vol. 17, # 1-3 p. 515 - 530

40615-36-9 ~% 207347-42-0

文献：Arslan, Tuncer; Abraham, Anil T.; Hecht, Sidney M. Nucleosides and Nucleotides, 1998 , vol. 17, # 1-3 p. 515 - 530

73-03-0 ~% 207347-42-0

文献：Charubala, Ramamurthy; Pfleidere, Wolfgang; Suhadolnik, Robert J.; Iacono, Kathryn T.; Muto, Nicholas F.; Homan, Joseph W.; Martinand-Mari, Camille; Horvath, Susan E.; Henderson, Earl E.; Steele, Amber; Rogers, Thomas J. Helvetica Chimica Acta, 2002 , vol. 85, # 8 p. 2284 - 2299

98-88-4 ~% 207347-42-0

文献：Charubala, Ramamurthy; Pfleidere, Wolfgang; Suhadolnik, Robert J.; Iacono, Kathryn T.; Muto, Nicholas F.; Homan, Joseph W.; Martinand-Mari, Camille; Horvath, Susan E.; Henderson, Earl E.; Steele, Amber; Rogers, Thomas J. Helvetica Chimica Acta, 2002 , vol. 85, # 8 p. 2284 - 2299

76902-49-3 ~% 207347-42-0

文献：Arslan, Tuncer; Abraham, Anil T.; Hecht, Sidney M. Nucleosides and Nucleotides, 1998 , vol. 17, # 1-3 p. 515 - 530

60855-35-8 ~% 207347-42-0

文献：Arslan, Tuncer; Abraham, Anil T.; Hecht, Sidney M. Nucleosides and Nucleotides, 1998 , vol. 17, # 1-3 p. 515 - 530

207347-41-9 ~% 207347-42-0

文献：Arslan, Tuncer; Abraham, Anil T.; Hecht, Sidney M. Nucleosides and Nucleotides, 1998 , vol. 17, # 1-3 p. 515 - 530

207347-40-8 ~% 207347-42-0

文献：Arslan, Tuncer; Abraham, Anil T.; Hecht, Sidney M. Nucleosides and Nucleotides, 1998 , vol. 17, # 1-3 p. 515 - 530

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