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112885-41-3生产厂家

112885-41-3价格

112885-41-3

112885-41-3结构式
112885-41-3结构式
  • 常用中文名:莫沙必利
  • 常用英文名:Mosapride
  • CAS号:112885-41-3
  • 分子式:C21H25ClFN3O3
  • 分子量:421.893
  • 相关类别: 原料药 消化系统用药 止吐催吐药
  • 发布时间:2018-02-05 08:00:00
  • 更新时间:2024-01-02 18:04:46
  • Mosapride是促胃肠动力化合物,是5HT4激动剂。

化源商城直购

中文名 莫沙必利
英文名 4-Amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide
中文别名 莫沙比利
英文别名 Benzamide, 4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-
4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide
MFCD00867430
Mosapride
(±)-4-Amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2-morpholinyl]methyl]benzamide
4-Amino-5-chloro-2-ethoxy-N-{[4-(4-fluorobenzyl)-2-morpholinyl]methyl}benzamide
4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]benzamide
4-amino-5-chloro-2-ethoxy-N-{[4-(4-fluorobenzyl)morpholin-2-yl]methyl}benzamide
密度 1.3±0.1 g/cm3
沸点 549.2±50.0 °C at 760 mmHg
熔点 151-153°C
分子式 C21H25ClFN3O3
分子量 421.893
闪点 286.0±30.1 °C
精确质量 421.156860
PSA 76.82000
LogP 2.82
外观性状 白色至灰白色结晶固体
蒸汽压 0.0±1.5 mmHg at 25°C
折射率 1.585
储存条件 -20°C Freezer
分子结构

1、 摩尔折射率:111.10

2、 摩尔体积(cm3/mol):331.6

3、 等张比容(90.2K):877.6

4、 表面张力(dyne/cm):49.0

5、 极化率(10-24cm3):44.04

计算化学

1.疏水参数计算参考值(XlogP):2.8

2.氢键供体数量:2

3.氢键受体数量:6

4.可旋转化学键数量:7

5.互变异构体数量:5

6.拓扑分子极性表面积76.8

7.重原子数量:29

8.表面电荷:0

9.复杂度:521

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:1

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

更多

1.熔点(ºC):151~153

Material Safety Data Sheet

Section1. Identification of the substance
Product Name: Mosapride
Synonyms:

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

Section3. Composition/information on ingredients.
Ingredient name:Mosapride
CAS number:112885-41-3

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C21H25ClFN3O3
Molecular weight:421.9

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride, hydrogen fluoride.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

毒理学数据:

枸橼酸莫沙必利,雄性、雌性,小鼠、大鼠LD50(mg/kg):>3000,>3000,>3000,1905经口;>10000,914,>1000,>1000腹膜内注射;全部>1000皮下注射;雄性、雌性狗经口(mg/kg):两者>400。

危害码 (欧洲) C,N,F+
风险声明 (欧洲) R14:Reacts violently with water. R34:Causes burns. R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . R12:Extremely Flammable.
安全声明 (欧洲) S26-S27-S28-S36/37/39-S45-S61-S33-S29-S16
危险品运输编码 UN 3260 8/PG 2
WGK德国 3
RTECS号 LW9100000
包装等级 II
危险类别 8
海关编码 2934999090

2-氨甲基-4-(4-氟苄基)吗啉溶于二氯甲烷,加入4-氨基-5-氯-2-乙氧基苯甲酸和1-乙基-3--(3-二甲氨基丙基)碳化二亚胺盐酸盐,在25%搅拌4h。反应液依次用水、氢氧化钠水溶液和饱和氯化钠水溶液洗,干燥。过
滤,减压浓缩,得到的物质用乙醇重结晶,得莫沙必利。将莫沙必利溶于乙醇,加入35%氯化氢的乙醇溶液过滤收集沉淀,用乙醇重结晶,得盐酸莫沙必利。将莫沙必利溶于热的10%枸橼酸水溶液,然后缓慢冷却过滤收集沉淀,得枸橼酸莫沙必利二水合物。

海关编码 2934999090
中文概述 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素 品名, 成分含量, 用途
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%