137863-20-8

• 常用中文名：缬沙坦苄酯
• 常用英文名：Valsartan benzyl ester
• CAS号：137863-20-8
• 分子式：C₃₁H₃₅N₅O₃
• 分子量：525.641
• 发布时间：2018-05-15 08:00:00
• 更新时间：2024-01-05 14:52:31
• Valsartan benzyl ester is a Valsartan intermediate.

名称

• 中文名: 缬沙坦苄酯
• 英文名: (S)-Benzyl 2-(N-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoate
• 中文别名: 缬沙坦相关物质C; 缬沙坦杂质B
• 英文别名: Valsartan benzyl ester; L-Valine, N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, phenylmethyl ester; Benzyl N-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valinate; benzyl (2S)-3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoate; T5MNNNJ ER BR D1NV4&YVO1R&Y1&1 &&L or S Form; Phenylmethyl N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valinate; Benzyl N-pentanoyl-N-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-L-valinate; Benzyl N-pentanoyl-N-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valinate; Valsartan Impurity 2

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 720.1±70.0 °C at 760 mmHg
• 熔点: >71° C(dec.)
• 分子式: C₃₁H₃₅N₅O₃
• 分子量: 525.641
• 闪点: 389.3±35.7 °C
• 精确质量: 525.273987
• PSA: 101.07000
• LogP: 7.16
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.589
• 储存条件: 室温

安全

• 危害码 (欧洲): Xn

合成路线

137864-44-9 ~90% 137863-20-8

文献：ENANTIA, S. L. Patent: WO2006/67216 A2, 2006 ; Location in patent: Page/Page column 29 ; WO 2006/067216 A2

137864-22-3 ~% 137863-20-8

文献：WO2005/49588 A1, ; Page/Page column 6 ;

676129-93-4 638-29-9 ~% 137863-20-8

文献：WO2004/26847 A1, ; Page 26; 32-33 ; WO 2004/026847 A1

67-56-1 137864-44-9 ~0% 137863-20-8 596-31-6

文献：ZENTIVA, a.s. Patent: WO2005/21535 A2, 2005 ; Location in patent: Page/Page column 15 ;

1315376-91-0 ~% 137863-20-8

文献：Organic Process Research and Development, , vol. 15, # 5 p. 986 - 988

上下游产品

上游产品  5
137864-44-9 137864-22-3 676129-93-4 638-29-9
67-56-1
下游产品  1
137862-53-4