6501-72-0

• 常用中文名：VGX-1027
• 常用英文名：VGX-1027(Git-27)
• CAS号：6501-72-0
• 分子式：C₁₁H₁₁NO₃
• 分子量：205.210
• 相关类别： 信号通路 免疫及炎症 白细胞介素相关
• 发布时间：2016-02-05 02:49:00
• 更新时间：2024-01-03 16:45:00
• VGX-1027(GIT27)具有免疫调节活性,能降低小鼠巨噬细胞的IL-1β,TNF-α和IL-10分泌。

名称

• 中文名: VGX-1027
• 英文名: 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid
• 英文别名: GIT 27; 3-phenyl-4,5-dihydro-5-isoxazoleacetic acid; 4,5-DIHYDRO-3-PHENYL-5-ISOXAZOLEACETIC ACID; (3-Phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid; 5-Isoxazoleacetic acid, 4,5-dihydro-3-phenyl-; VGX-1027

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 381.4±34.0 °C at 760 mmHg
• 熔点: 159 °C
• 分子式: C₁₁H₁₁NO₃
• 分子量: 205.210
• 闪点: 184.5±25.7 °C
• 精确质量: 205.073898
• PSA: 58.89000
• LogP: 1.16
• 外观性状: 固体;White to Orange to Green powder to crystal
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.601
• 储存条件: 0-10°C;存放于惰性气体之中;避免空气,加热

生物活性

• 描述: VGX-1027(GIT27)具有免疫调节活性,能降低小鼠巨噬细胞的IL-1β,TNF-α和IL-10分泌。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 白细胞介素相关
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Stosic-Grujicic S, et al. A potent immunomodulatory compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multipl

  [2]. Stojanovic I, et al. In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027: modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models. Clin Immuno

  [3]. Mangano K, et al. In vitro inhibition of enterobacteria-reactive CD4+CD25- T cells and suppression of immunoinflammatory colitis in mice by the novel immunomodulatory agent VGX-1027. Eur J Pharmacol. 2008 May 31;586(1-3):313-21.

合成路线

1378834-78-6 625-38-7 ~% 6501-72-0

文献：GANIAL IMMUNOTHERAPEUTICS INC. Patent: WO2006/97273 A1, 2006 ; Location in patent: Page/Page column 13 ;

613-91-2 ~% 6501-72-0

文献：Eichinger, Karl; Wokurek, Michael; Zauner, Bernd; Rostami, Mohammad Reza Synthetic Communications, 1997 , vol. 27, # 16 p. 2733 - 2742

625-38-7 698-16-8 ~% 6501-72-0

文献：Stosic-Grujicic, Stanislava; Cvetkovic, Ivana; Mangano, Katia; Fresta, Massimo; Maksimovic-Ivanic, Danijela; Harhaji, Ljubica; Popadic, Dusan; Momcilovic, Miljana; Miljkovic, Djordje; Kim, Joseph; Al Abed, Yousef; Nicoletti, Ferdinando Journal of Pharmacology and Experimental Therapeutics, 2007 , vol. 320, # 3 p. 1038 - 1049

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