VGX-1027

• 常用名: VGX-1027
• 英文名: VGX-1027(Git-27)
• CAS号: 6501-72-0
• 分子量: 205.210
• 密度: 1.3±0.1 g/cm3
• 沸点: 381.4±34.0 °C at 760 mmHg
• 分子式: C₁₁H₁₁NO₃
• 熔点: 159 °C
• 闪点: 184.5±25.7 °C

VGX-1027用途

VGX-1027(GIT27)具有免疫调节活性,能降低小鼠巨噬细胞的IL-1β,TNF-α和IL-10分泌。

VGX-1027名称

• 中文名: VGX-1027
• 英文名: 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid

VGX-1027生物活性

• 描述: VGX-1027(GIT27)具有免疫调节活性,能降低小鼠巨噬细胞的IL-1β,TNF-α和IL-10分泌。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 白细胞介素相关
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Stosic-Grujicic S, et al. A potent immunomodulatory compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multipl

  [2]. Stojanovic I, et al. In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027: modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models. Clin Immuno

  [3]. Mangano K, et al. In vitro inhibition of enterobacteria-reactive CD4+CD25- T cells and suppression of immunoinflammatory colitis in mice by the novel immunomodulatory agent VGX-1027. Eur J Pharmacol. 2008 May 31;586(1-3):313-21.

VGX-1027物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 381.4±34.0 °C at 760 mmHg
• 熔点: 159 °C
• 分子式: C₁₁H₁₁NO₃
• 分子量: 205.210
• 闪点: 184.5±25.7 °C
• 精确质量: 205.073898
• PSA: 58.89000
• LogP: 1.16
• InChIKey: MUFJHYRCIHHATF-UHFFFAOYSA-N
• SMILES: O=C(O)CC1CC(c2ccccc2)=NO1
• 外观性状: 固体;White to Orange to Green powder to crystal
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.601
• 储存条件: 0-10°C;存放于惰性气体之中;避免空气,加热

VGX-1027靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2 来源：NCGC 靶标：eyes absent homolog 2 isoform a [Homo sapiens] External Id：EYA2477

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：qHTS Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2... 来源：NCGC 靶标：ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] External Id：UBCH001

实验名称：qHTS assay for measurement of the activity of small molecule inhibitors on Zika virus... 来源：NCGC 靶标：N/A External Id：ZIK159

实验名称：qHTS screen for enhancers of Arylsulfatase A (ASA1): LOPAC Validation Assay 来源：NCGC 靶标：arylsulfatase A [Homo sapiens] External Id：asa1-v2

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

实验名称：Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screeni... 来源：NCGC 靶标：N/A External Id：CPF001

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VGX-1027英文别名

• GIT 27
• 3-phenyl-4,5-dihydro-5-isoxazoleacetic acid
• 4,5-DIHYDRO-3-PHENYL-5-ISOXAZOLEACETIC ACID
• (3-Phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid
• VGX-1027