132-98-9

• 常用中文名：青霉素V钾
• 常用英文名：Penicillin V potassium
• CAS号：132-98-9
• 分子式：C₁₆H₁₇KN₂O₅S
• 分子量：388.480
• 相关类别： 原料药 抗生素类药物 青霉素类药
• 发布时间：2018-02-08 08:00:00
• 更新时间：2026-07-01 18:13:56
• Penicillin V钾盐是一种抗生素, 用于治疗多种细菌感染, 是一种口服类的青霉素。

名称

• 中文名: 青霉素V钾
• 英文名: phenoxymethylpenicillin potassium
• 中文别名: 化合物：Penicillin V Potassium (Phenoxymethylpenicillin potassium salt); 青霉素V钾盐 标准品; 3,3-二甲基-7-氧代-6-(2-苯氧基乙酰胺基)-4-硫-1-氮杂双环; 青霉素V钾 颗粒状的; 青霉素钾-D5; 青霉素V钾(标准品); 苯氧甲基青霉素钾 标准品; 青霉素V钾盐/3,3-二甲基-7-氧代-6-(2-苯氧基乙酰胺基)-4-硫-1-氮杂双环[3.2.0]庚烷-2-羧酸钾盐; 苯氧基甲基青霉素钾盐; 苯氧甲基青霉素 钾盐; 苯氧甲基青霉素(苄星青霉素)杂质H; 青霉素V钾盐HPLC; 化合物:Penicillin V Potassium (Phenoxymethylpenicillin potassium salt); 青霉素V钾、青霉素V/苯氧甲基青霉素; 青霉素V/苯氧甲基青霉素; 苯氧甲基青霉素钾盐(青霉素V钾盐) 标准品; 青霉素V钾盐/苯氧甲基青霉素; 3,3-二甲基-7-氧代-6-(2-苯氧基乙酰胺基)-4-硫-1-氮杂双环[3.2.0]庚烷-2-羧酸钾盐; 苯氧甲基青霉素钾盐(青霉素V钾盐); 青霉素V钾/A1A; 青霉素V钾盐PENICILLIN V POTASSIUM SALT; PENICILLIN V POTASSIUM SALT 青霉素V钾; 青霉素V钾(苯氧甲基青霉素); 青霉素V钾 标准品; 青霉素V钾盐; 青霉素 V 钾; (2S,5R,6R)-3,3-二甲基-7-氧代-6-(2-苯氧基乙酰胺基)-4-硫杂-1-氮杂二环[3.2.0]庚-2-羧酸钾
• 英文别名: kavenin; megacillinoral; PHENOXYMETHYLPENICILLIN K+ SALT; PHENOXYMETHYL PENICILLIN POTASSIUM SALT; EINECS 205-086-5; dqv-k; [2S-(2a,5a,6b)]-3,3-Dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Potassium Salt; Penicillin V (Potassium); pfizerpenvk; qidpenvk; d-alpha-phenoxymethylpenicillinateksalt; MFCD00051771; sk-penicillinvk; Penicillin V Potassium Salt; compocillin-vk; potassiumpenicillinvsalt; robicillinvk; dowpenv-k; pvk; distakapsv-k; orapen; isocillin; penagen; roscopenin; abicyclo[3.2.0]htane-2-cboxylate; PENICILLINE V POTASSIUM SALT; cliacil; Penicillin V potassium salt, Phenoxymethylpenicillinic acid potassium salt; PHENOXYMETHYLPENICILLINIC ACID POTASSIUM SALT; Penicillin V potassium salt,Phenoxymethylpenicillin potassium salt; pen-v-kpowder; potassiumphenoxymethylpenicillin; PENICILLIN VK; distaquainev-k; stabillinvksyrup62.5; pen-oral; 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(2-phenoxyacetyl)amino]-, potassium salt, (2S,5R,6R)- (1:1); penicillinpotassiumphenoxymethyl; D-a-Phenoxymethylpenicillinate K Salt; stabillinvksyrup125; PENICILLIN V POTASSIUM; PENICILLIN V; pen-vee-kpowder; monopotassiumsalt,(2s-(2alpha,5alpha,6beta))-enoxyacetyl)amino); primcillin; sumapenvk; potassiumpenicillinv; pedipen; Phenoxymethylpenicillin Potassium; dov-k; phenoxymethylpenicillinicacid*potassium; (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-((phenoxyacetyl)amino)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid Monopotassium Salt; ospeneff; (2S,5R,6R)-3,3-diméthyl-7-oxo-6-[(phénoxyacétyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate de potassium; monopotassiumsalt,[2s-(2alpha,5alpha,6beta)]-noxyacetyl)amino]; PHENOXYMETHYLPENICILLIN POTASSIUM; 4-thia-1-azabicyclo(3.2.0)htane-2-cboxylicacid,3,3-dimethyl-7-oxo-6-((ph; oracil-vk; pen-vee-k; ledercillinvk; penapvk; rocillin-vk; ispenoral; monopotassium(2s,5r,6r)-3,3-dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-az; penvikal; PENICILLIN V POTASSIUM SALT; calciopenk; Potassium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; pencompren; icipen; fenoxypen

物化性质

• 密度: 1.40
• 沸点: 681.4ºC at 760 mmHg
• 熔点: 197-202°C
• 分子式: C₁₆H₁₇KN₂O₅S
• 分子量: 388.480
• 闪点: 365.9ºC
• 精确质量: 388.049530
• PSA: 124.07000
• 外观性状: 白色至灰白色结晶粉末
• 蒸汽压: 1.69E-19mmHg at 25°C
• 储存条件:

  贮存

  密封于阴凉干燥处保存。

• 稳定性:

  基本性质

  结晶。溶于水。比旋光度[α]_D²⁵ +223°（C=0.2）。半数致死量（大鼠，经口）＞1040mg/kg。

• 计算化学:

  1、 疏水参数计算参考值（XlogP）：

  2、 氢键供体数量：1

  3、 氢键受体数量：5

  4、 可旋转化学键数量：5

  5、 互变异构体数量：2

  6、 拓扑分子极性表面积（TPSA）：98.8

  7、 重原子数量：25

  8、 表面电荷：0

  9、 复杂度：553

  10、同位素原子数量：0

  11、确定原子立构中心数量：3

  12、不确定原子立构中心数量：0

  13、确定化学键立构中心数量：0

  14、不确定化学键立构中心数量：0

  15、共价键单元数量：2

• 更多:

  1. 性状：结晶

生物活性

• 描述: Penicillin V钾盐是一种抗生素, 用于治疗多种细菌感染, 是一种口服类的青霉素。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  天然产物 >> 其他
  研究领域 >> 感染

毒性和生态

毒理学数据: 急性毒性数据： 大鼠经口LD50：>1040mg/kg 大鼠腹腔LD50：1750mg/kg 大鼠肌内LD50：1124mg/kg 小鼠经口LD50：>4mg/kg 小鼠腹腔LD50：1351mg/kg 小鼠皮下LD50：>4mg/kg 小鼠静脉LD50:1mg/kg 其他多剂量数据： 其它多剂量数据 大鼠经口TDLo：195mg/kg/13W-I 小鼠经口TDLo：16250mg/kg/13W-I 致突变数据： 人类淋巴细胞：3mg/L 小鼠淋巴细胞：250mg/L 啮齿动物-仓鼠卵巢：9mg/L 姐妹染色单体啮齿动物-仓鼠卵巢：500mg/L CHEMICAL IDENTIFICATION RTECS NUMBER : XH9275000 CHEMICAL NAME : 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(2-phenoxy- acetamido)-, monopotassium salt CAS REGISTRY NUMBER : 132-98-9 LAST UPDATED : 199707 DATA ITEMS CITED : 17 MOLECULAR FORMULA : C16-H17-N2-O5-S.K MOLECULAR WEIGHT : 388.51 WISWESSER LINE NOTATION : T45 ANV ESTJ CMV1OR& F1 F1 GVQ &-KA- HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >1040 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1750 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1124 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1351 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 195 gm/kg/13W-I TOXIC EFFECTS : Gastrointestinal - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 16250 mg/kg/13W-I TOXIC EFFECTS : Gastrointestinal - other changes MUTATION DATA TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 500 mg/L REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-336,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82270 No. of Facilities: 1844 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 3026 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82270 No. of Facilities: 301 (estimated) No. of Industries: 2 No. of Occupations: 11 No. of Employees: 6483 (estimated) No. of Female Employees: 3052 (estimated)

安全

• 符号: GHS07, GHS08
• 信号词: Danger
• 危害声明: H302-H317-H334
• 警示性声明: P261-P280-P284-P301 + P312 + P330-P304 + P340-P342 + P311
• 个人防护装备: dust mask type N95 (US);Eyeshields;Faceshields;Gloves
• 危害码 (欧洲): Xn:Harmful;
• 风险声明 (欧洲): R22;R42/43
• 安全声明 (欧洲): S22-S26-S36/37-S45
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: XH9275000
• 海关编码: 2941109400

合成路线

551-16-6 ~% 132-98-9

文献：WO2014/71283 A1, ;

701-99-5 ~% 132-98-9

文献：WO2014/71283 A1, ;

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551-16-6 701-99-5
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海关

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