753498-25-8

• 常用中文名：马来酸茚达特罗
• 常用英文名：Indacaterol Maleate
• CAS号：753498-25-8
• 分子式：C₂₈H₃₂N₂O₇
• 分子量：508.563
• 相关类别： 生物化工 抑制剂 神经信号通路(Neuronal Signaling) Adrenergic Receptor 激动剂
• 发布时间：2018-03-28 08:00:00
• 更新时间：2026-07-10 22:00:53
• Indacaterol(Onbrez; Arcapta)马来酸盐是超长效β-肾上腺素受体激动剂。

名称

• 中文名: 马来酸茚达特罗
• 英文名: indacaterol maleate
• 中文别名: 马来酸茚达特罗(API); 马来酸吲达卡特罗; 马来酸盐茚达特罗杂质; 印达特罗中间体; 马来酸茚达特罗, 一种超长效Β-肾上腺素受体激动剂; 茚达特罗马来酸盐(API); 马来酸茚达特罗,10 MM DMSO 溶液; 茚达特罗马来酸盐; 马来酸茚达特罗INDACATEROL MALEATE; 茚达特罗顺丁烯二酸盐; 茚达特罗马来酸; 马来酸盐茚达特罗
• 英文别名: 2(1H)-Quinolinone, 5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-, (2Z)-2-butenedioate (1:1); Indacaterol Maleate //BP; UNII-2JEC1ITX7R; QAB 149 Maleic Acid; Onbrez Breezhaler; Onbrez maleate; Indacaterol maleate an ultra-long-acting β-adrenoctor agonist; Indacaterol maleate, 10 mM in DMSO; (R)-5-(2-((5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino)-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one maleate; Indacaterol maleate salt; Onbrez; capta maleate; Indacaterol Maleate(API); 5-{(1R)-2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl}-8-hydroxy-2(1H)-quinolinone (2Z)-2-butenedioate (1:1); (Z)-but-2-enedioic acid,5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one; Indatol maleate; (R)-5-[2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hy; QAB-149 maleate; Indacaterol Maleate (QAB149); Indacaterolmaleate; Indacaterol Maleic Acid Salt; 2(1H)-Quinolinone, 5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl] -8-hydroxy-, (2Z)-2-butenedioate (1:1) (salt); 5-[(1R)-2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-2(1H)-quinolinone (2Z)-2-butenedioate; [(2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxooxolan-2-yl]methyl benzoate; 5-[(1R)-2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-2(1H)-quinolinone Maleic Acid; Indacaterol (maleate); Arcapta neohaler; ndacaterol Maleate; Hirobriz Breezhaler; 2(1H)-Quinolinone, 5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-, (2Z)-2-butenedioate (1:1) (salt); Indacaterol maleic acid; IndacaterolMaleate>; Oslif Breezhaler

物化性质

• 分子式: C₂₈H₃₂N₂O₇
• 分子量: 508.563
• 精确质量: 508.220947
• PSA: 160.21000
• LogP: 3.66390
• 储存条件: 2~8℃

生物活性

• 描述: Indacaterol(Onbrez; Arcapta)马来酸盐是超长效β-肾上腺素受体激动剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
  研究领域 >> 其他
• 参考文献:

  [1]. Battram, C., et al., In vitro and in vivo pharmacological characterization of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-o ne (indacaterol), a novel inhaled beta(2) adrenoceptor agonist with a 24-h duration of action. J Pharmacol Exp Ther, 2006. 317(2): p. 762-70.

  [2]. Sturton, R.G., et al., Pharmacological characterization of indacaterol, a novel once daily inhaled 2 adrenoceptor agonist, on small airways in human and rat precision-cut lung slices. J Pharmacol Exp Ther, 2008. 324(1): p. 270-5.

安全

• 危害码 (欧洲): Xi