753498-25-8

• 常用中文名：马来酸茚达特罗
• 常用英文名：Indacaterol Maleate
• CAS号：753498-25-8
• 分子式：C₂₈H₃₂N₂O₇
• 分子量：508.563
• 相关类别： 生物化工 抑制剂 神经信号通路(Neuronal Signaling) Adrenergic Receptor 激动剂
• 发布时间：2018-03-28 08:00:00
• 更新时间：2024-01-02 17:06:22
• Indacaterol(Onbrez; Arcapta)马来酸盐是超长效β-肾上腺素受体激动剂。

名称

• 中文名: 马来酸茚达特罗
• 英文名: indacaterol maleate
• 英文别名: QAB-149 maleate; Indacaterolmaleate; UNII-2JEC1ITX7R; Onbrez Breezhaler; Arcapta neohaler; Hirobriz Breezhaler; 5-{(1R)-2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl}-8-hydroxy-2(1H)-quinolinone (2Z)-2-butenedioate (1:1); 2(1H)-Quinolinone, 5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-, (2Z)-2-butenedioate (1:1) (salt); (Z)-but-2-enedioic acid,5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one; Indacaterol Maleate; Oslif Breezhaler; Indacaterol (maleate)

物化性质

• 分子式: C₂₈H₃₂N₂O₇
• 分子量: 508.563
• 精确质量: 508.220947
• PSA: 160.21000
• LogP: 3.66390
• 储存条件: 2~8℃

生物活性

• 描述: Indacaterol(Onbrez; Arcapta)马来酸盐是超长效β-肾上腺素受体激动剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
  研究领域 >> 其他
• 参考文献:

  [1]. Battram, C., et al., In vitro and in vivo pharmacological characterization of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-o ne (indacaterol), a novel inhaled beta(2) adrenoceptor agonist with a 24-h duration of action. J Pharmacol Exp Ther, 2006. 317(2): p. 762-70.

  [2]. Sturton, R.G., et al., Pharmacological characterization of indacaterol, a novel once daily inhaled 2 adrenoceptor agonist, on small airways in human and rat precision-cut lung slices. J Pharmacol Exp Ther, 2008. 324(1): p. 270-5.

安全

• 危害码 (欧洲): Xi