马来酸茚达特罗

• 常用名: 马来酸茚达特罗
• 英文名: Indacaterol Maleate
• CAS号: 753498-25-8
• 分子量: 508.563
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₈H₃₂N₂O₇
• 熔点: N/A
• 闪点: N/A

马来酸茚达特罗用途

Indacaterol(Onbrez; Arcapta)马来酸盐是超长效β-肾上腺素受体激动剂。

马来酸茚达特罗名称

• 中文名: 马来酸茚达特罗
• 英文名: indacaterol maleate

马来酸茚达特罗生物活性

• 描述: Indacaterol(Onbrez; Arcapta)马来酸盐是超长效β-肾上腺素受体激动剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
  研究领域 >> 其他
• 参考文献:

  [1]. Battram, C., et al., In vitro and in vivo pharmacological characterization of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-o ne (indacaterol), a novel inhaled beta(2) adrenoceptor agonist with a 24-h duration of action. J Pharmacol Exp Ther, 2006. 317(2): p. 762-70.

  [2]. Sturton, R.G., et al., Pharmacological characterization of indacaterol, a novel once daily inhaled 2 adrenoceptor agonist, on small airways in human and rat precision-cut lung slices. J Pharmacol Exp Ther, 2008. 324(1): p. 270-5.

马来酸茚达特罗物理化学性质

• 分子式: C₂₈H₃₂N₂O₇
• 分子量: 508.563
• 精确质量: 508.220947
• PSA: 160.21000
• LogP: 3.66390
• InChIKey: IREJFXIHXRZFER-PCBAQXHCSA-N
• SMILES: CCc1cc2c(cc1CC)CC(NCC(O)c1ccc(O)c3[nH]c(=O)ccc13)C2.O=C(O)C=CC(=O)O
• 储存条件: 2~8℃

马来酸茚达特罗安全信息

• 危害码 (欧洲): Xi

马来酸茚达特罗靶点实验

查看更多实验

实验名称：Tmax in healthy human at 800 ug, po as single dose by LC-MS/MS analysis 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL3532830

实验名称：Drug recovery in healthy human feces at 800 ug, po as single dose measured after 168 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3536084

实验名称：Drug recovery in healthy human feces at 800 ug, po as single dose after 168 hrs postd... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3536100

实验名称：Drug recovery in healthy human urine at 800 ug, po as single dose after 168 hrs postd... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3536098

实验名称：AUC (0 to 12 hrs) in healthy human at 800 ug, po as single dose by LC-MS/MS analysis 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL3536082

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

共8条，当前第1页，共1页

1

马来酸茚达特罗英文别名

• QAB-149 maleate
• Indacaterolmaleate
• UNII-2JEC1ITX7R
• Onbrez Breezhaler
• Arcapta neohaler
• Hirobriz Breezhaler
• 5-{(1R)-2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl}-8-hydroxy-2(1H)-quinolinone (2Z)-2-butenedioate (1:1)
• 2(1H)-Quinolinone, 5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-, (2Z)-2-butenedioate (1:1) (salt)
• (Z)-but-2-enedioic acid,5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one
• Indacaterol Maleate
• Oslif Breezhaler
• Indacaterol (maleate)